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    Method of adding marker dye to nutritional product during enternal tube feeding
    4.
    发明授权
    Method of adding marker dye to nutritional product during enternal tube feeding 失效
    在内管喂养期间向营养产品添加标记染料的方法

    公开(公告)号：US5746715A

    公开(公告)日：1998-05-05

    申请号：US673446

    申请日：1996-06-28

    申请人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek ,  Susan Beth Duel ,  Andre Daab-Krzykowski ,  Robert Louis Joseph ,  William Guy Pierson ,  Thomas Daniel Loughrin ,  Thomas Walter Osip

    发明人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek ,  Susan Beth Duel ,  Andre Daab-Krzykowski ,  Robert Louis Joseph ,  William Guy Pierson ,  Thomas Daniel Loughrin ,  Thomas Walter Osip

    IPC分类号： A61J15/00 ,  A61M5/00 ,  A61M5/14 ,  A61M31/00 ,  A61M37/00

    CPC分类号： A61M31/002 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407 ,  A61J15/00

    摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.

    摘要翻译： 一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置， 可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。 持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。 标记染料可以是着色剂染料或荧光染料或其混合物。 如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。

    Oral administration of beneficial agents
    6.
    发明授权
    Oral administration of beneficial agents 失效
    口服有益药物

    公开(公告)号：US5921955A

    公开(公告)日：1999-07-13

    申请号：US3718

    申请日：1998-01-05

    申请人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek

    发明人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek

    IPC分类号： A47G21/18 ,  A61J7/00 ,  A61J9/00 ,  A61M37/00

    CPC分类号： A61J9/006 ,  A47G21/183 ,  A61J7/00 ,  A61J7/0038 ,  A61J7/0046 ,  A61J9/00

    摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure extending transversely across an imperforate walled zone such as the upper end or neck of a bottle or vessel, or of a funnel-like adapter attached to the top of the vessel, with a retention pocket with liquid penetrable walls held by the support structure and comprising at least one beneficial agent secured therein whereby the beneficial agent is taken up in the liquid for drinking during or just prior to oral administration. The beneficial agent may be in either or both of controlled release dosage form or non-controlled release dosage form and may be one or more of nutrients, medicaments, probiotics, electrolytes, rehydration solutions and diagnostic agents, to which a flavoring agent may be added. In the novel method a support structure with a retention pocket comprising at least one beneficial agent is provided in a bottle or vessel with the support structure extending transversely of the neck or top of the bottle or vessel or a drinking tube extending thereinto. The bottle or vessel is provided with a liquid for drinking selected from a liquid nutritional product, a beverage or water and the liquid is contacted with the beneficial agent during or just before oral administration thereof.

    摘要翻译： 用于在口服给药期间将有益剂添加到用于饮用的液体中的装置包括横向跨越无孔壁区域（例如瓶或容器的上端或颈部）延伸的支撑结构，或者连接到顶部的漏斗状适配器 所述容器具有保持袋，其具有由所述支撑结构保持的液体可穿透壁，并且包含固定在其中的至少一种有益剂，由此所述有益剂在所述液体中被吸收以在口服给药期间或之前口服。 有益药物可以是控制释放剂型或非控释剂型中的一种或两种，并且可以是可以加入调味剂的营养素，药物，益生菌，电解质，补液溶液和诊断剂中的一种或多种 。 在新颖方法中，在瓶或容器中提供具有包含至少一种有益剂的保留袋的支撑结构，其中支撑结构横向延伸到瓶或容器的颈部或顶部或延伸到其中的饮用管。 在瓶子或容器中设置有用于饮用的液体，所述液体选自液体营养产品，饮料或水，并且在口服给药期间或之前将液体与有益剂接触。

    Oral administration of beneficial agents
    7.
    发明授权
    Oral administration of beneficial agents 失效

    公开(公告)号：US5707353A

    公开(公告)日：1998-01-13

    申请号：US576728

    申请日：1995-12-21

    申请人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek

    发明人： Terrence Bruce Mazer ,  Joseph Edward Walton ,  Ronita Kay Geckle ,  Carl Joseph Piontek

    IPC分类号： A47G21/18 ,  A61J7/00 ,  A61J9/00 ,  A61M37/00

    CPC分类号： A61J9/006 ,  A47G21/183 ,  A61J7/00 ,  A61J7/0038 ,  A61J7/0046 ,  A61J9/00

    摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure extending transversely across an imperforate walled zone such as the upper end or neck of a bottle or vessel, or of a funnel-like adapter attached to the top of the vessel, with a retention pocket with liquid penetrable walls held by the support structure and comprising at least one beneficial agent secured therein whereby the beneficial agent is taken up in the liquid for drinking during or just prior to oral administration. The beneficial agent may be in either or both of controlled release dosage form or non-controlled release dosage form and may be one or more of nutrients, medicaments, probiotics, electrolytes, rehydration solutions and diagnostic agents, to which a flavoring agent may be added. In the novel method a support structure with a retention pocket comprising at least one beneficial agent is provided in a bottle or vessel with the support structure extending transversely of the neck or top of the bottle or vessel or a drinking tube extending thereinto. The bottle or vessel is provided with a liquid for drinking selected from a liquid nutritional product, a beverage or water and the liquid is contacted with the beneficial agent during or just before oral administration thereof.