-
1.发明申请公开(公告)号：US20060127950A1
公开(公告)日：2006-06-15
申请号：US11244826
申请日：2005-10-06
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
2.发明授权公开(公告)号：US08000904B2
公开(公告)日：2011-08-16
申请号：US12574161
申请日：2009-10-06
申请人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
发明人： Nishla Keiser , Carlos Bosques , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram , Aravind Srinivasan
IPC分类号： G01N31/00
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
3.发明申请公开(公告)号：US20100144553A1
公开(公告)日：2010-06-10
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B40/12
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
4.发明申请公开(公告)号：US20060057638A1
公开(公告)日：2006-03-16
申请号：US11107982
申请日：2005-04-15
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
5.发明申请公开(公告)号：US20120289415A1
公开(公告)日：2012-11-15
申请号：US13478662
申请日：2012-05-23
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B20/08
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G16C20/20
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
6.发明授权公开(公告)号：US08209132B2
公开(公告)日：2012-06-26
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： G01N31/00
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
-
7.发明申请公开(公告)号：US20100136599A1
公开(公告)日：2010-06-03
申请号：US12574161
申请日：2009-10-06
申请人： Pankaj Gandhe , Sasi Raguram , Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan
发明人： Pankaj Gandhe , Sasi Raguram , Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Ram Sasisekharan
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6851 , G01N2400/10 , Y10T436/143333
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及对蛋白质上发现的碳水化合物如N-聚糖和O-聚糖的分析。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 关于聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化对蛋白质功能的影响的研究。 还提供了这样的方法。 还提供了评估蛋白质生产过程，评估产生的蛋白质的纯度和选择具有所需糖基化的蛋白质的方法。
-
8.发明申请公开(公告)号：US20080241918A1
公开(公告)日：2008-10-02
申请号：US11893171
申请日：2007-08-14
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
-
9.发明申请公开(公告)号：US20090269342A1
公开(公告)日：2009-10-29
申请号：US12348266
申请日：2009-01-02
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K16/18 , C12N7/00 , A61K38/02 , C40B40/10 , C40B30/04 , G01N33/566
CPC分类号： G01N33/56983 , C07K14/005 , C12N2760/16122 , G01N2333/11 , G01N2400/10 , G01N2500/02
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
-
10.发明申请HEMAGGLUTININ POLYPEPTIDES, AND REAGENTS AND METHODS RELATING THERETO 审中-公开HEMAGGLUTININ POLYPEPTIDES，以及与其相关的试剂和方法公开(公告)号：US20090081193A1
公开(公告)日：2009-03-26
申请号：US11969040
申请日：2008-01-03
申请人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人： Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号： A61K39/395 , C07K14/435 , C07H21/00 , C12N15/64 , C12N1/21 , A61K31/7088 , A61P31/16 , C07K16/08 , C12N7/01 , C40B40/12 , A61K38/16
CPC分类号： G01N33/5308 , G01N2400/10
摘要： The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译： 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽，以及与其相关的试剂和方法。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.046 秒)
