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    1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases
    1.
    发明授权
    1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases 有权
    1H-咪唑并[4,5-c]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用

    公开(公告)号：US07998972B2

    公开(公告)日：2011-08-16

    申请号：US10515126

    申请日：2003-05-20

    申请人： Carlos Garcia-Echeverria ,  Hans-Georg Capraro ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Hans-Georg Capraro ,  Pascal Furet

    IPC分类号： A61K31/4166 ,  A61K31/4188 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

    摘要翻译： 本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉， 所述疾病包括将咪唑并喹啉给予包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的药物制剂，以及制备新的咪唑并喹啉的方法。

    4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives
    2.
    发明申请
    4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives 审中-公开
    4-氨基-5-苯基-7-环己基 - 吡咯并[2,3-d]嘧啶衍生物

    公开(公告)号：US20060058324A1

    公开(公告)日：2006-03-16

    申请号：US10534427

    申请日：2003-11-11

    申请人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria

    发明人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria

    IPC分类号： A61K31/519 ,  C07D487/02

    CPC分类号： C07D487/04

    摘要： The invention relates to new 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof, alone or in combination with one or more other pharmaceutically active compounds, for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound, alone or in combination with one or more other pharmaceutically active compounds, for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.

    摘要翻译： 本发明涉及新的4-氨基-5-苯基-7-环己基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法，其在治疗人或动物体的方法中的应用， 单独或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病如肿瘤疾病的用途，用于治疗哺乳动物，特别是人类中的这些疾病的方法， 以及这种化合物单独或与一种或多种其它药学活性化合物组合用于制备用于特别是增殖性疾病如肿瘤的药物组合物（药物）的用途。

    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives
    4.
    发明授权
    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives 失效
    4-氨基-5-苯基-7-环丁基 - 吡咯并（2,3-d）嘧啶衍生物

    公开(公告)号：US07326699B2

    公开(公告)日：2008-02-05

    申请号：US10477594

    申请日：2002-05-13

    申请人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    发明人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    IPC分类号： C07D417/06 ,  C07D417/12 ,  C07D487/04 ,  C07D403/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/12 ,  A61K31/55 ,  A61K31/541 ,  A61K31/5355 ,  A61K31/497 ,  A61K31/519 ,  A61P35/04

    CPC分类号： C07D487/04

    摘要： The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.

    摘要翻译： 本发明涉及新的4-氨基-5-苯基-7-环丁基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法及其在治疗人或动物体的方法中的应用， 其用途 - 单独使用或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病，例如肿瘤疾病，哺乳动物，特别是人类中的这些疾病的治疗方法， 以及这种化合物单独使用或与一种或多种其它药学活性化合物组合的用途，用于制备特别是增殖性疾病如肿瘤的药物组合物（药物）。

    1h-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases
    5.
    发明申请
    1h-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases 有权
    1h-咪唑并[4,5-c]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用

    公开(公告)号：US20050245562A1

    公开(公告)日：2005-11-03

    申请号：US10515126

    申请日：2003-05-20

    申请人： Carlos Garcia-Echeverria ,  Hans-Georg Capraro ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Hans-Georg Capraro ,  Pascal Furet

    IPC分类号： A61K31/4745 ,  A61P13/08 ,  A61P17/06 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

    摘要翻译： 本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉， 所述疾病包括将咪唑并喹啉给予包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的药物制剂，以及制备新的咪唑并喹啉的方法。

    1,3-dihydro-imidazo [4,5-C] quinolin-2-ones as lipid kinase inhibitors
    6.
    发明授权
    1,3-dihydro-imidazo [4,5-C] quinolin-2-ones as lipid kinase inhibitors 有权
    1,3-二氢 - 咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂

    公开(公告)号：US07667039B2

    公开(公告)日：2010-02-23

    申请号：US11913788

    申请日：2006-05-18

    申请人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

    摘要翻译： 本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物 用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

    1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors
    9.
    发明授权
    1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors 有权
    1,3-二氢 - 咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂

    公开(公告)号：US07994170B2

    公开(公告)日：2011-08-09

    申请号：US12577268

    申请日：2009-10-12

    申请人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    IPC分类号： C07D471/04 ,  A61K31/4188

    CPC分类号： C07D471/04

    摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

    摘要翻译： 本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物 用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。