公开(公告)号：US20070154395A1

公开(公告)日：2007-07-05

申请号：US11706809

申请日：2007-02-15

申请人： Carol Morris ,  Fiona Carney ,  Jennifer Lane

发明人： Carol Morris ,  Fiona Carney ,  Jennifer Lane

IPC分类号： A61K49/00 ,  C12Q1/54

CPC分类号： G01N33/6893 ,  G01N33/66 ,  G01N2800/042

摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

摘要翻译： 本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。 本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间段确定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。 本发明的方法通过使用本发明的试剂盒进行。 该试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。 葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

公开(公告)号：US20050038329A1

公开(公告)日：2005-02-17

申请号：US10706208

申请日：2003-11-12

申请人： Carol Morris ,  Fiona Carney ,  Jennifer Lane

发明人： Carol Morris ,  Fiona Carney ,  Jennifer Lane

IPC分类号： A61B5/00 ,  C12Q1/54 ,  G01N33/66 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/66 ,  G01N2800/042

摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

摘要翻译： 本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。 本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间段确定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。 本发明的方法通过使用本发明的试剂盒进行。 该试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。 葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

公开(公告)号：US20070197931A1

公开(公告)日：2007-08-23

申请号：US11787681

申请日：2007-04-17

申请人： Fiona Carney ,  Carol Morris

发明人： Fiona Carney ,  Carol Morris

IPC分类号： A61B10/00 ,  G01N33/53

CPC分类号： A61B5/42 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4306 ,  A61B10/0012 ,  A61B10/0045 ,  A61B2010/0067

摘要： The invention provides methods and kits for monitoring the status of women's health, including HRT monitoring and determination or diagnosis of ovulation, contraception, pregnancy, menopause, polycystic ovarian disease, and female sexual dysfunction. The method comprises the steps of: (a) collecting a tear fluid from a female human; (b) determining the tear concentration of at least one hormone of relevance to female fertility, sexual differentiation or sexual dysfunction in a female human, wherein the tear concentration is diagnostics of the status of women's health.

摘要翻译： 本发明提供了监测妇女健康状况的方法和工具，包括HRT监测和排卵，避孕，怀孕，绝经，多囊卵巢疾病和女性性功能障碍的确定或诊断。 该方法包括以下步骤：（a）从女性人体收集泪液; （b）确定与女性生殖力，性别分化或性功能障碍相关的至少一种激素的泪液浓度，其中泪液浓度是对妇女健康状况的诊断。

公开(公告)号：US20050106207A1

公开(公告)日：2005-05-19

申请号：US10969280

申请日：2004-10-20

申请人： Yongxing Qiu ,  Fiona Carney ,  Nichola Kotov ,  John Lally ,  Carol Morris ,  Lynn Winterton

发明人： Yongxing Qiu ,  Fiona Carney ,  Nichola Kotov ,  John Lally ,  Carol Morris ,  Lynn Winterton

IPC分类号： G02C7/04 ,  A61F9/00 ,  A61L27/00 ,  A61L27/30 ,  A61L27/34 ,  A61L31/08 ,  A61L31/10 ,  G02B1/04 ,  A61F2/00 ,  A61J1/00

CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

公开(公告)号：US20070140911A1

公开(公告)日：2007-06-21

申请号：US11706808

申请日：2007-02-15

申请人： Flona Carney ,  Jennifer Lane ,  Carol Morris

发明人： Flona Carney ,  Jennifer Lane ,  Carol Morris

IPC分类号： B01L3/00

CPC分类号： A61B10/0045 ,  A61B2010/0067

摘要： The invention, in one aspect, provides a strip for tear collection. The strip has a first end and an opposite second end and preferably has substantially uniform cross-sections from the first end to the second end. The strip is made of a hydrogel material in substantially dry state. The strip is characterized by having a substantially uniform swelling along the hydrogel strip from the first end to the second end when fully wicked by a tear fluid and by having a correlation between the volume of tear uptake by said strip and the length of the wicked end portion of said strip. A strip of the invention is useful for assay of an analyte of interest in a tear fluid. The invention also provides a method and kits for assaying an analyte of interest (e.g., lactoferrin, glucose, herpes simplex virus, hormones, etc.).

摘要翻译： 本发明在一个方面提供了一种用于撕裂收集的条带。 带材具有第一端和相对的第二端，并且优选地具有从第一端到第二端的基本均匀的横截面。 条带由基本上干燥状态的水凝胶材料制成。 该条带的特征在于，当被泪液完全弄脏时，沿着水凝胶条具有从第一端到第二端的基本上均匀的溶胀，并且通过所述带的撕裂吸收体积与邪恶端的长度之间的相关性 所述条的一部分。 本发明的条带可用于测定泪液中感兴趣的分析物。 本发明还提供了用于测定感兴趣分析物（例如乳铁蛋白，葡萄糖，单纯疱疹病毒，激素等）的方法和试剂盒。

公开(公告)号：US20050124011A1

公开(公告)日：2005-06-09

申请号：US10896868

申请日：2004-07-23

申请人： Carol Morris ,  Mark Willcox ,  Shirley Bolis ,  Bradley Walsh ,  Ben Herbert ,  Mark Molloy ,  Andrew Gooley ,  Keith Williams

发明人： Carol Morris ,  Mark Willcox ,  Shirley Bolis ,  Bradley Walsh ,  Ben Herbert ,  Mark Molloy ,  Andrew Gooley ,  Keith Williams

IPC分类号： C07K14/47 ,  G01N33/574 ,  G01N33/53

CPC分类号： C07K14/47 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57488

摘要： A method of screening or detecting non-ocular disease in an animal, the method comprising the steps of: (a) obtaining a tear sample from the animal; (b) separating biomolecules present in the tear sample; and (c) detecting for the presence or absence of one or more biomolecules such that the presence or absence of the one or more biomolecules being an indicator or marker of a disease state in the animal.

摘要翻译： 一种在动物中筛选或检测非眼部疾病的方法，所述方法包括以下步骤：（a）从动物获得泪液样品; （b）分离存在于泪液样品中的生物分子; 和（c）检测一种或多种生物分子的存在或不存在，使得一种或多种生物分子的存在或不存在是动物中疾病状态的指示剂或标志物。