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公开(公告)号：US06555066B2
公开(公告)日：2003-04-29
申请号：US09810747
申请日：2001-03-16
IPC分类号： G01N3316
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus for performing a platelet inhibition test on a sample of blood is provided, comprising a plurality of test cells, the cells being adapted for receiving an aliquot portion of the sample, wherein each of the cells comprises an anticoagulant and a clotting activator, and wherein at least one of the cells further comprises a platelet inactivating agent, wherein a clotting time is determined for each of the aliquot portions, and wherein a relative clotting time for each of the aliquot portions comprising the platelet inhibitor is determined as compared to a reference clotting time for a cell containing no platelet inhibitor, wherein the relative clotting times for the cells are determinative of the platelet inhibition of the sample.
摘要翻译： 提供了一种用于对血液样品进行血小板抑制试验的装置，包括多个测试细胞，所述细胞适于接收样品的等分试样部分，其中每个细胞包含抗凝血剂和凝血活化剂，以及 其中所述细胞中的至少一个还包含血小板失活剂，其中为每个等分试样部分确定凝血时间，并且其中与参考物相比确定包含血小板抑制剂的每个等分试样部分的相对凝血时间 不含血小板抑制剂的细胞的凝血时间，其中细胞的相对凝血时间决定了样品的血小板抑制。
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公开(公告)号：US06232127B1
公开(公告)日：2001-05-15
申请号：US09330545
申请日：1999-06-11
IPC分类号： G01N3386
CPC分类号： G01N33/4905 , G01N33/86 , G01N2400/40 , G01N2405/04 , Y10T436/10 , Y10T436/107497 , Y10T436/108331
摘要： An improved apparatus and method for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells includes a platelet function restoration agent, an anticoagulant agent, and a clotting reagent. At least one of the cells also includes a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method includes the steps of combining a platelet function restoration agent, an anticoagulant agent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by adding a clotting reagent to the test mixture at the start of the activated clotting time test, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于评估血液样品的血小板功能的改进的装置和方法。 该装置包括多个测试单元。 每个细胞包括血小板功能恢复剂，抗凝血剂和凝血试剂。 至少一个细胞还包括血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括将血小板功能恢复剂，抗凝血剂，血小板活化剂和待测试血液样品组合以形成测试混合物的步骤。 在激活的凝血时间试验开始时，通过向试验混合物中加入凝血试剂来激活样品的血小板，并且在检测到试验混合物的性质的预定变化后终止活化的凝固时间试验。 根据经过的时间计算血液样品的活化凝血时间。
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3.发明授权Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique 失效用于执行不依赖肝素的高灵敏度血小板功能评估技术的装置
公开(公告)号：US6010911A
公开(公告)日：2000-01-04
申请号：US847152
申请日：1997-04-30
CPC分类号： G01N33/86 , G01N2333/988 , G01N2400/40 , G01N2800/52 , Y10T436/101666 , Y10T436/108331
摘要： An apparatus and method for performing activated clotting time tests, including their use for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells comprises a heparin-inactivating agent, an anticoagulant agent, and a clotting reagent. At least one of the test cells further comprises a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method comprises the steps of combining a heparin-inactivating agent, an anticoagulant agent, a clotting reagent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by agitating the test mixture, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于进行活化凝血时间测试的装置和方法，包括其用于评估血液样品的血小板功能性的用途。 该装置包括多个测试单元。 每个细胞包含肝素灭活剂，抗凝血剂和凝血试剂。 至少一个测试细胞还包含血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括以下步骤：将肝素灭活剂，抗凝血剂，凝血试剂，血小板活化剂和待测血液样品混合以形成试验混合物。 通过搅拌测试混合物来激活样品的血小板，并且在检测到测试混合物的性质的预定变化后终止活化的凝血时间测试。 根据经过的时间计算血液样品的活化凝血时间。
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公开(公告)号：US06221672B1
公开(公告)日：2001-04-24
申请号：US09225051
申请日：1999-01-04
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： A method of determining a dose response for a platelet inhibitor. The method includes the steps of placing a predetermined amount of heparin in each cell of a multicell test cartridge, placing an optimized amount of a clotting activator in each cell, and placing a measured amount of platelet inhibitor in each cell, the amount of inhibitor in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inhibitor are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to calculate and determine the platelet inhibition effect of the platelet inhibitor.
摘要翻译： 确定血小板抑制剂的剂量反应的方法。 该方法包括以下步骤：在多细胞测试盒的每个细胞中放置预定量的肝素，在每个细胞中放置优化量的凝血活化剂，并将测量量的血小板抑制剂置于每个细胞中， 每个细胞与每个细胞中的量不同。 将血液样品的等分试样加入到每个细胞中，并将血液样品等分试样，凝血试剂和血小板抑制剂混合。 允许每个细胞样品凝块，并测量每个细胞的凝固时间。 使用相对凝血时间来计算并确定血小板抑制剂的血小板抑制作用。
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公开(公告)号：US5925319A
公开(公告)日：1999-07-20
申请号：US640275
申请日：1996-04-30
CPC分类号： G01N33/86
摘要： Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.
摘要翻译： 用于评估血液样品的血小板功能的装置和方法。 盒包括多个测试单元。 每个细胞接收血液样品的等分部分。 在每个细胞中提供测量量的凝血试剂。 在每个细胞中提供测量量的血小板活化试剂，每个细胞中的这种试剂的量与每个其它细胞中的这种试剂的量不同。 细胞中等分试样的相对凝血时间决定了血液样品的血小板功能。
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公开(公告)号：US06761856B2
公开(公告)日：2004-07-13
申请号：US10410003
申请日：2003-04-09
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets, the apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.
摘要翻译： 提供了一种用于对含有血小板的样品进行活化的凝血时间测试的装置，所述装置包括多个测试细胞，所述细胞适于接收所述样品的等分部分，其中每个所述细胞包含抗凝血剂和 血小板灭活剂，并且其中所述细胞中的至少一个还包含凝血活化剂，其中确定每个所述等分部分的凝血时间，并且其中确定包含凝血激活剂的每个所述等分部分的相对凝血时间 与所述至少一种不含凝血活化剂的细胞的参考凝血时间相比，其中所述细胞中的所述相对凝血时间决定所述凝血活化剂的凝血活化。
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7.发明授权
公开(公告)号：US5972712A
公开(公告)日：1999-10-26
申请号：US249349
申请日：1999-02-11
CPC分类号： G01N33/86 , G01N2333/988 , G01N2400/40 , G01N2800/52 , Y10T436/101666 , Y10T436/108331
摘要： An method for performing activated clotting time tests, including a method for evaluating platelet functionality of a blood sample. The method includes the steps of combining a heparin-inactivating agent, an anticoagulant agent, a sufficient amount of clotting reagent to achieve clotting, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelet activating agent is a reagent other than the clotting reagent. The platelets of the sample are activated by agitating the test mixture, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time. The activated clotting time test may be performed using a plunger sensor apparatus which comprises a plurality of test cells. In this method, each of the cells of the apparatus includes a heparin-inactivating agent, an anticoagulant agent, and a sufficient amount of a clotting reagent to achieve clotting. At least one of the test cells further includes a platelet activating agent, which is a reagent other than the clotting reagent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample.
摘要翻译： 一种用于进行活化凝血时间测试的方法，包括评估血液样品的血小板功能的方法。 该方法包括以下步骤：将肝素灭活剂，抗凝血剂，足够量的凝血试剂结合以实现凝血，血小板活化剂和待测试血液样品以形成测试混合物。 血小板活化剂是凝血试剂以外的试剂。 通过搅拌测试混合物来激活样品的血小板，并且在检测到测试混合物的性质的预定变化后终止活化的凝血时间测试。 根据经过的时间计算血液样品的活化凝血时间。 活化的凝血时间试验可以使用包括多个测试电池的柱塞传感器装置进行。 在该方法中，该装置的每个细胞包括肝素灭活剂，抗凝血剂和足够量的凝血试剂以实现凝血。 至少一个测试细胞还包括作为凝血试剂以外的试剂的血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。
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公开(公告)号：US5951951A
公开(公告)日：1999-09-14
申请号：US846318
申请日：1997-04-30
CPC分类号： G01N33/4905 , G01N33/86 , G01N2400/40 , G01N2405/04 , Y10T436/10 , Y10T436/107497 , Y10T436/108331
摘要： An improved apparatus and method for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells includes a platelet function restoration agent, an anticoagulant agent, and a clotting reagent. At least one of the cells also includes a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method includes the steps of combining a platelet function restoration agent, an anticoagulant agent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by adding a clotting reagent to the test mixture at the start of the activated clotting time test, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
摘要翻译： 一种用于评估血液样品的血小板功能的改进的装置和方法。 该装置包括多个测试单元。 每个细胞包括血小板功能恢复剂，抗凝血剂和凝血试剂。 至少一个细胞还包括血小板活化剂。 确定每个等分部分的凝血时间，细胞中等分试样部分的相对凝固时间决定于样品的血小板功能。 该方法包括将血小板功能恢复剂，抗凝血剂，血小板活化剂和待测试血液样品组合以形成测试混合物的步骤。 在激活的凝血时间试验开始时，通过向试验混合物中加入凝血试剂来激活样品的血小板，并且在检测到试验混合物的性质的预定变化后终止活化的凝固时间试验。 根据经过的时间计算血液样品的活化凝血时间。
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公开(公告)号：US06955920B1
公开(公告)日：2005-10-18
申请号：US09330544
申请日：1999-06-11
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.
摘要翻译： 用于评估血液样品的血小板功能的装置和方法。 盒包括多个测试单元。 每个细胞接收血液样品的等分部分。 在每个细胞中提供测量量的凝血试剂。 在每个细胞中提供测量量的血小板活化试剂，每个细胞中的这种试剂的量与每个其它细胞中的这种试剂的量不同。 细胞中等分试样的相对凝血时间决定了血液样品的血小板功能。
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公开(公告)号：US06555381B2
公开(公告)日：2003-04-29
申请号：US09810740
申请日：2001-03-16
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/101666 , Y10T436/12
摘要： A method of determining a contact activator for platelet activation and/or clotting activation is provided, comprising placing a predetermined amount of an anticoagulant in each cell of a multicell test cartridge, placing a predetermined amount of a platelet inactivating agent in each cell, and placing a measured amount of contact activator in each cell, the amount of contact activator in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inactivating agent are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to determine the platelet activation and/or clotting activation effect of the clotting activator.
摘要翻译： 提供了确定血小板激活和/或凝血活化的接触激活剂的方法，包括将预定量的抗凝血剂置于多细胞试验盒的每个细胞中，在每个细胞中放置预定量的血小板失活剂，并将 每个电池中的测量量的接触活化剂，每个电池中的接触活化剂的量不同于每个电池中的量。 将血液样品的等分试样加入到每个细胞中，并将血液样品等分试样，凝血试剂和血小板灭活剂混合。 允许每个细胞样品凝块，并测量每个细胞的凝固时间。 相对凝血时间用于确定凝血激活剂的血小板活化和/或凝血活化作用。
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