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公开(公告)号：US08865868B2
公开(公告)日：2014-10-21
申请号：US13055871
申请日：2009-08-06
申请人： Carsten Behrens , Patrick William Garibay , Søren Østergaard , Henrik Sune Andersen , Nils Langeland Johansen , Bernd Peschke , Sonja Bak
发明人： Carsten Behrens , Patrick William Garibay , Søren Østergaard , Henrik Sune Andersen , Nils Langeland Johansen , Bernd Peschke , Sonja Bak
IPC分类号： C07K1/113 , C07K14/745 , A61K47/48 , A61K38/36
CPC分类号： A61K47/48023 , A61K47/54 , A61K47/64
摘要： The invention relates to conjugated proteins, in particular but not exclusively, blood coagulation factors, to processes for preparing the conjugated proteins which contain the steps of reacting a protein or glycoprotein, such as factor VIIa or human growth hormone, with a water insoluble albumin binder in the presence of an optionally substituted cyclodextrin molecule, to pharmaceutical compositions comprising the protein conjugates and to the use of the protein conjugates in therapy, in particular but not exclusively, for the treatment of diseases alleviated by blood coagulation factors such as the prophylactic treatment of hemophilia.
摘要翻译： 本发明涉及缀合蛋白，特别是但不仅限于血液凝固因子，用于制备缀合蛋白的方法，其包含使蛋白质或糖蛋白（例如因子VIIa或人生长激素）与水不溶性白蛋白结合物 在任选取代的环糊精分子的存在下，包含蛋白质缀合物的药物组合物和蛋白质缀合物在治疗中的用途，特别但不排他地用于治疗由凝血因子减轻的疾病，例如预防性治疗 血友病。
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公开(公告)号：US09695226B2
公开(公告)日：2017-07-04
申请号：US13522390
申请日：2011-01-24
申请人： Carsten Behrens , Nils Langeland Johansen , Henrik Sune Andersen , Leif Noerskov-Lauritsen , Jens Buchardt
发明人： Carsten Behrens , Nils Langeland Johansen , Henrik Sune Andersen , Leif Noerskov-Lauritsen , Jens Buchardt
CPC分类号： C12N15/70 , A61K47/54 , A61K47/542 , A61K47/545 , C07K14/61 , G01N2030/027
摘要： The invention relates to growth hormone compounds with a protracted profile. The effect is obtained by linking an albumin binding residue via a hydrophilic spacer to growth hormone variants. Further described are methods of preparing and using such compounds. These growth hormone compounds are based on there altered profile considered particular useful in therapy.
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公开(公告)号：US20120172303A1
公开(公告)日：2012-07-05
申请号：US13389180
申请日：2010-08-06
申请人： Nils Langeland Johansen , Henrik Sune Andersen , Jens Buchardt , Carsten Behrens , Leif Norskov-Lauritsen , Jing Su
发明人： Nils Langeland Johansen , Henrik Sune Andersen , Jens Buchardt , Carsten Behrens , Leif Norskov-Lauritsen , Jing Su
CPC分类号： A61K47/64 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/545 , A61K47/60
摘要： The present invention relates to polypeptide compound optimized for subcutaneous administration, exemplified by growth hormone conjugates having a linker providing non-covalent binding to albumin.
摘要翻译： 本发明涉及针对皮下给药优化的多肽化合物，例如具有提供与白蛋白非共价结合的接头的生长激素缀合物。
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公开(公告)号：US20120309944A1
公开(公告)日：2012-12-06
申请号：US13522390
申请日：2011-01-24
申请人： Carsten Behrens , Nils Langeland Johansen , Henrik Sune Andersen , Leif Noerskov-Lauritsen , Jens Buchardt
发明人： Carsten Behrens , Nils Langeland Johansen , Henrik Sune Andersen , Leif Noerskov-Lauritsen , Jens Buchardt
IPC分类号： C07K14/61 , C07C235/74 , C07C237/22 , C07K5/09 , C07C237/24 , C07D207/452 , C07C237/34 , C07D257/04 , C07C309/18
CPC分类号： C12N15/70 , A61K47/54 , A61K47/542 , A61K47/545 , C07K14/61 , G01N2030/027
摘要： The invention relates to growth hormone compounds with a protracted profile. The effect is obtained by linking an albumin binding residue via a hydrophilic spacer to growth hormone variants. Further described are methods of preparing and using such compounds. These growth hormone compounds are based on there altered profile considered particular useful in therapy.
摘要翻译： 本发明涉及具有延长轮廓的生长激素化合物。 通过将白蛋白结合残基通过亲水间隔物连接到生长激素变体来获得该效果。 进一步描述了制备和使用这些化合物的方法。 这些生长激素化合物基于被认为在治疗中特别有用的改变的特征。
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公开(公告)号：US20110223151A1
公开(公告)日：2011-09-15
申请号：US13055871
申请日：2009-08-06
申请人： Carsten Behrens , Patrick William Garibay , Soren Østergaard , Henrik Sune Andersen , Johansen Nils Langeland , Peschke Bernd , Bak Sonja
发明人： Carsten Behrens , Patrick William Garibay , Soren Østergaard , Henrik Sune Andersen , Johansen Nils Langeland , Peschke Bernd , Bak Sonja
CPC分类号： A61K47/48023 , A61K47/54 , A61K47/64
摘要： The invention relates to conjugated proteins, in particular but not exclusively, blood coagulation factors, to processes for preparing said conjugates, to pharmaceutical compositions comprising said conjugates and to the use of the conjugates in therapy, in particular but not exclusively, for the treatment of diseases alleviated by blood coagulation factors such as the prophylactic treatment of hemophilia.
摘要翻译： 本发明涉及缀合蛋白，特别是但不仅限于，凝血因子，制备所述缀合物的方法，包含所述缀合物的药物组合物以及所述缀合物在治疗中的用途，特别是但不排他地用于治疗 通过凝血因子如血友病的预防性治疗减轻疾病。
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公开(公告)号：US20130143815A1
公开(公告)日：2013-06-06
申请号：US13809681
申请日：2011-07-15
申请人： Henrik Sune Andersen , Kjeld Madsen , Helle Demuth , Christine Bruun Schioedt , Leif Noerskov-Lauritsen , Peter Thygesen , Carsten Behrens , Mette Guldbrandt
发明人： Henrik Sune Andersen , Kjeld Madsen , Helle Demuth , Christine Bruun Schioedt , Leif Noerskov-Lauritsen , Peter Thygesen , Carsten Behrens , Mette Guldbrandt
IPC分类号： C07K14/61
CPC分类号： C07K14/61 , A61K47/554
摘要： The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
摘要翻译： 本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变体氨基酸残基进行。 生长激素多肽可以是人生长激素或生长激素变体。
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公开(公告)号：US20090227504A1
公开(公告)日：2009-09-10
申请号：US12371156
申请日：2009-02-13
CPC分类号： A61K38/4846 , A61K47/60 , C07K14/755
摘要： The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group.
摘要翻译： 本发明涉及包含多个因子VII多肽或因子VII相关多肽的制剂，其中所述多肽包含天冬酰胺连接和/或丝氨酸连接的寡糖链，并且其中至少一个寡糖基团共价连接至至少一个聚合物 组。
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8.发明申请Condensed Thiophene Derivatives and Their Use as Cyclic Glp-1 Agonists 审中-公开缩合噻吩衍生物及其作为循环Glp-1激动剂的用途公开(公告)号：US20080275066A1
公开(公告)日：2008-11-06
申请号：US11630007
申请日：2005-06-21
申请人： Sanne Moller Knudsen , Ingrid Pettersson , Jesper Lau , Carsten Behrens , Anders Klarskov Petersen , Jesper Lau , Patrick William Garibay
发明人： Sanne Moller Knudsen , Ingrid Pettersson , Jesper Lau , Carsten Behrens , Anders Klarskov Petersen , Jesper Lau , Patrick William Garibay
IPC分类号： A61K31/519 , C07D333/62 , A61K31/381 , A61K31/4365 , C07D495/04
CPC分类号： C07D495/04 , C07D333/72 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/14
摘要： The invention provides compounds of formula (I) for use as GLP-1 receptor agonists.
摘要翻译： 本发明提供用作GLP-1受体激动剂的式（I）化合物。
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公开(公告)号：US20080108557A1
公开(公告)日：2008-05-08
申请号：US11664199
申请日：2005-09-29
CPC分类号： C12P21/005 , A61K47/60 , C07K1/1077 , C07K9/003
摘要： A method of conjugating peptides and proteins by means of glycosyltransferase is provided.
摘要翻译： 提供了通过糖基转移酶缀合肽和蛋白质的方法。
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10.发明申请Use of Galactose Oxidase for Selective Chemical Conjugation of Protractor Molecules to Proteins of Therapeutic Interest 审中-公开半乳糖氧化酶用于选择性化学结合量角器分子对治疗兴趣蛋白质的应用公开(公告)号：US20100028939A1
公开(公告)日：2010-02-04
申请号：US12060383
申请日：2008-04-01
申请人： Carsten Behrens , Patrick William Garibay , Magali Zundel , Niels Kristian Klausen , Soren E. Bjorn
发明人： Carsten Behrens , Patrick William Garibay , Magali Zundel , Niels Kristian Klausen , Soren E. Bjorn
IPC分类号： C12P21/00 , C07K14/435 , C07K14/745
CPC分类号： C12P21/005 , A61K47/549 , A61K47/60 , C12N9/6437
摘要： This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.
摘要翻译： 本发明涉及新化合物，量角器分子的选择性化学共轭的方法及其用于诊断和/或治疗目的的用途。
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