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35 条记录 (耗时 0.051 秒)

    Spectral diagnosis of diseased tissue
    5.
    发明授权
    Spectral diagnosis of diseased tissue 失效
    患病组织的光谱诊断

    公开(公告)号：US5421337A

    公开(公告)日：1995-06-06

    申请号：US219240

    申请日：1994-03-29

    申请人： Rebecca Richards-Kortum ,  Lucene Tong ,  Michael S. Feld

    发明人： Rebecca Richards-Kortum ,  Lucene Tong ,  Michael S. Feld

    IPC分类号： A61B5/00 ,  A61B6/00

    CPC分类号： A61B5/42 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0075

    摘要： The present invention relates to a method and apparatus for diagnosing the condition of gastrointestinal tissue. The method and apparatus excite fluorophores within a portion of gastrointestinal tissue with a laser to cause the fluorophores to emit fluorescent radiation. The presence of abnormal tissue is then determined by detecting the radiation emitted by the excited fluorophores and comparing the emitted radiation to a reference emission for fluorophores within normal tissue at predetermined wavelengths.

    摘要翻译： 本发明涉及一种诊断胃肠道组织状况的方法和装置。 该方法和装置用激光激发胃肠道组织部分内的荧光团，使荧光团发出荧光辐射。 然后通过检测由激发的荧光团发射的辐射并将发射的辐射与在预定波长的正常组织内的荧光团的参考发射进行比较来确定异常组织的存在。

    BIOSPECIFIC CONTRAST AGENTS
    6.
    发明申请
    BIOSPECIFIC CONTRAST AGENTS 审中-公开
    BIOSPECIFIC对比代理

    公开(公告)号：US20090068108A1

    公开(公告)日：2009-03-12

    申请号：US11877476

    申请日：2007-10-23

    申请人： Konstantin Sokolov ,  Brian A. Korgel ,  Andrew D. Ellington ,  Rebecca Richards-Kortum

    发明人： Konstantin Sokolov ,  Brian A. Korgel ,  Andrew D. Ellington ,  Rebecca Richards-Kortum

    IPC分类号： A61K49/00 ,  G01N33/543 ,  A61P35/00

    CPC分类号： A61B5/0059 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61K49/00 ,  A61K49/0017 ,  A61K49/0058 ,  A61K49/0067 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/587 ,  G01N33/588

    摘要： Methods and apparatuses for detecting a condition of a sample (including cervical cancers and pre-cancers) through reflectance and/or fluorescence imaging. A sample is obtained. One or more metallic nanoparticles and/or one or more quantum dots are obtained. The one or more metallic nanoparticles and/or one or more quantum dots are coupled to one or more biomarkers of the sample that are associated with the condition. A reflectance and/or fluorescence image of the sample is then taken. The image(s) exhibit characteristic optical scattering from the one or more metallic nanoparticles and/or characteristic fluorescence excitation from the one or more quantum dots to signal the presence of the one or more biomarkers. In this way, the condition can be readily screened or diagnosed.

    摘要翻译： 通过反射和/或荧光成像检测样品（包括宫颈癌和癌前病症）的方法和装置。 获得样品。 获得一种或多种金属纳米颗粒和/或一个或多个量子点。 将一种或多种金属纳米颗粒和/或一个或多个量子点偶联到与该条件相关联的样品的一个或多个生物标志物上。 然后取样品的反射率和/或荧光图像。 该图像表现出来自一种或多种金属纳米颗粒的特征光学散射和/或来自一个或多个量子点的特征荧光激发以发出一个或多个生物标志物的存在。 以这种方式，可以容易地筛选或诊断病症。

    Methods and apparatus for diagnostic multispectral digital imaging
    9.
    发明授权
    Methods and apparatus for diagnostic multispectral digital imaging 有权
    诊断多光谱数字成像的方法和装置

    公开(公告)号：US06766184B2

    公开(公告)日：2004-07-20

    申请号：US09821786

    申请日：2001-03-28

    申请人： Urs Utzinger ,  Rebecca Richards-Kortum ,  Calum MacAuldy ,  Michele Follen

    发明人： Urs Utzinger ,  Rebecca Richards-Kortum ,  Calum MacAuldy ,  Michele Follen

    IPC分类号： A61B505

    CPC分类号： A61B1/00186 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/303 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086

    摘要： Methods and apparatus for generating multispectral images of tissue. The multispectral images may be used as a diagnostic tool for conditions such as cervical cancer detection and diagnosis. Primary radiation is produced with an illumination source. The primary radiation is filtered to select a first wavelength and a first polarization. Tissue is illuminated with the filtered primary radiation to generate secondary radiation, which is filtered to select a second wavelength and a second polarization. The filtered secondary radiation is collected with a detector, and a plurality of multispectral images of the tissue is generated according to different combinations of first and second wavelengths and first and second polarization with an analysis unit in operable relation with the detector. Apparatus utilizing the invention include endoscopes and colposcopes.

    摘要翻译： 用于生成组织多光谱图像的方法和装置。 多光谱图像可以用作诸如宫颈癌检测和诊断的诊断工具。 主要辐射是用照明源产生的。 对主辐射进行滤波以选择第一波长和第一偏振。 组织用经滤波的主辐射照射以产生二次辐射，其被滤波以选择第二波长和第二极化。 用检测器收集滤波后的二次辐射，根据第一和第二波长的不同组合以及与检测器可操作的分析单元产生第一和第二极化的组织的多个多光谱图像。 利用本发明的装置包括内窥镜和阴道镜。

    Spectroscopic method and apparatus for optically detecting abnormal mammalian epithelial tissue
    10.
    发明授权
    Spectroscopic method and apparatus for optically detecting abnormal mammalian epithelial tissue 失效
    用于光学检测异常哺乳动物上皮组织的光谱法和装置

    公开(公告)号：US6095982A

    公开(公告)日：2000-08-01

    申请号：US988840

    申请日：1997-12-11

    申请人： Rebecca Richards-Kortum ,  Nirmala Ramanujam ,  Anita Mahadevan ,  Michele Follen Mitchell

    发明人： Rebecca Richards-Kortum ,  Nirmala Ramanujam ,  Anita Mahadevan ,  Michele Follen Mitchell

    IPC分类号： A61B5/00 ,  G01N21/64 ,  G01N21/65 ,  G01N21/76 ,  G01N33/483 ,  A61B6/00

    CPC分类号： G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4331 ,  A61B5/7264 ,  G01N21/65 ,  A61B5/0086 ,  G01N2021/656

    摘要： A method and apparatus for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence or Raman spectroscopy, or a combination of fluorescence and Raman spectroscopy. In vivo fluorescence measurements were followed by in vitro NIR Raman measurements on human cervical biopsies. Fluorescence spectra collected at 337, 380 and 460 nm excitation were used to develop a diagnostic method to differentiate between normal and dysplastic tissues. Using a fluorescence diagnostic method, a sensitivity and specificity of 80% and 67% were observed for differentiating squamous intraepithelial lesions (SILs) from all other tissues. In accordance with another aspect of the invention, using Raman scattering peaks observed at selected wavenumbers, SILs were separated from other tissues with a sensitivity and specificity of 88% and 100%. In addition, inflammation and metaplasia samples are correctly separated from the SILs.

    摘要翻译： 一种用于通过荧光或拉曼光谱法或荧光和拉曼光谱的组合检测组织异常，特别是癌前期宫颈组织的方法和装置。 体内荧光测量之后是人体宫颈活检的体外NIR拉曼测量。 使用在337,380和460nm激发下收集的荧光光谱来开发用于区分正常组织和发育不良组织的诊断方法。 使用荧光诊断方法，从所有其他组织中鉴别出鳞状上皮内病变（SILs）的灵敏度和特异度为80％和67％。 根据本发明的另一方面，使用在选定波数处观察到的拉曼散射峰，将SIL与其他组织分离，灵敏度和特异性为88％和100％。 此外，炎症和化生样本正确地从SILs分离。