公开(公告)号：US20150377857A1

公开(公告)日：2015-12-31

申请号：US14766523

申请日：2014-02-10

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Brian T. Grimberg ,  Robert Deissler ,  William Condit ,  Robert Brown ,  Jason Jones ,  Richard Bihary

IPC: G01N33/49 ,  G01N1/28 ,  G01N21/59

CPC classification number: G01N33/48 ,  G01N1/28 ,  G01N21/21 ,  G01N21/59 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.

Abstract translation: 提供一种诊断装置，其包括用于将光束通过血液样本传输到光检测器的光源和永磁体，其中永磁体和血液样本中的一个可自动地相对于另一个在“HIGH” 磁状态位置和“低”磁状态位置，使得基本上高的磁场被施加到血液样本，导致血样中的任何血红素趋向于垂直取向于大体上的磁场，并抑制或增强光 基于其极化，并且将零到接近零的磁场施加到血液样品，导致血液样品中任何血红素的随机化，并且基线量的光通过血液样本在“低”磁性 状态。

公开(公告)号：US09778245B2

公开(公告)日：2017-10-03

申请号：US15425729

申请日：2017-02-06

Applicant: Case Western Reserve University

Inventor： Brian T. Grimberg ,  Robert Deissler ,  William Condit ,  Robert Brown ,  Jason Jones ,  Richard Bihary

IPC: G01N33/48 ,  G01N33/49

CPC classification number: G01N33/48 ,  G01N1/28 ,  G01N21/21 ,  G01N21/59 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.

公开(公告)号：US20170146513A1

公开(公告)日：2017-05-25

申请号：US15425729

申请日：2017-02-06

Applicant: Case Western Reserve University

Inventor： Brian T. Grimberg ,  Robert Deissler ,  William Condit ,  Robert Brown ,  Jason Jones ,  Richard Bihary

IPC: G01N33/49 ,  G01N21/59 ,  G01N27/72 ,  G01N21/21

CPC classification number: G01N33/48 ,  G01N1/28 ,  G01N21/21 ,  G01N21/59 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.

公开(公告)号：US09575052B2

公开(公告)日：2017-02-21

申请号：US14766523

申请日：2014-02-10

Applicant: Case Western Reserve University

Inventor： Brian T. Grimberg ,  Robert Deissler ,  William Condit ,  Robert Brown ,  Jason Jones ,  Richard Bihary

IPC: G01N33/48 ,  G01N33/49 ,  G01N21/21 ,  G01N1/28 ,  G01N21/59

CPC classification number: G01N33/48 ,  G01N1/28 ,  G01N21/21 ,  G01N21/59 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.

Abstract translation: 提供一种诊断装置，其包括用于将光束通过血液样本传输到光检测器的光源和永磁体，其中永磁体和血液样本中的一个可自动地相对于另一个在“HIGH” 磁状态位置和“低”磁状态位置，使得基本上高的磁场被施加到血液样本，导致血样中的任何血红素趋向于垂直取向于大体上的磁场，并抑制或增强光 基于其极化，并且将零到接近零的磁场施加到血液样品，导致血液样品中任何血红素的随机化，并且基线量的光通过血液样本在“低”磁性 状态。