公开(公告)号：US10598747B2

公开(公告)日：2020-03-24

申请号：US15946922

申请日：2018-04-06

申请人： Case Western Reserve University ,  The General Hospital Corporation

发明人： Vikas Gulani ,  Mark A. Griswold ,  Alice Yang ,  Yun Jiang ,  Kawin Setsompop

IPC分类号： G01R33/483 ,  G01R33/56 ,  G01R33/54 ,  G01R33/24 ,  G01R33/561 ,  G01R33/50

摘要： A magnetic resonance fingerprinting (“MRF”) framework that implements simultaneous multislice acquisition techniques with a Hadamard RF-encoding to simultaneously acquire magnetic resonance data from multiple slices simultaneously is described. As one non-limiting example, magnetic resonance data can be simultaneously acquired from four different slices. In other embodiments, however, the Hadamard encoding can be condensed into one or two acquisitions, rather than four.

公开(公告)号：US20180292486A1

公开(公告)日：2018-10-11

申请号：US15946922

申请日：2018-04-06

申请人： Case Western Reserve University ,  The General Hospital Corporation

发明人： Vikas Gulani ,  Mark A. Griswold ,  Alice Yang ,  Yun Jiang ,  Kawin Setsompop

IPC分类号： G01R33/483 ,  G01R33/56 ,  G01R33/24 ,  G01R33/54 ,  G01R33/50

CPC分类号： G01R33/4835 ,  G01R33/243 ,  G01R33/246 ,  G01R33/50 ,  G01R33/543 ,  G01R33/5608 ,  G01R33/561

摘要： A magnetic resonance fingerprinting (“MRF”) framework that implements simultaneous multislice acquisition techniques with a Hadamard RF-encoding to simultaneously acquire magnetic resonance data from multiple slices simultaneously is described. As one non-limiting example, magnetic resonance data can be simultaneously acquired from four different slices. In other embodiments, however, the Hadamard encoding can be condensed into one or two acquisitions, rather than four.

公开(公告)号：US20200341092A1

公开(公告)日：2020-10-29

申请号：US16859175

申请日：2020-04-27

申请人： Case Western Reserve University

发明人： Yun Jiang ,  Mark A. Griswold ,  Gregor Korzdorfer ,  Mathias Nittka

IPC分类号： G01R33/50 ,  G01R33/56 ,  G01R33/54 ,  G01R33/48 ,  G01R33/561 ,  A61B5/055

摘要： A system and method is provided for acquisition of magnetic resonance fingerprinting (“MRF”) data that includes determining a non-locally sequential sampling pattern for a Cartesian grid of k-space, performing a series of sequence blocks using acquisition parameters that vary between sequence blocks to acquire MRF data from a subject using the Cartesian grid of k-space and the determined non-locally sequential sampling pattern, assembling the MRF data into a series of signal evolutions, comparing the series of signal evolutions to a dictionary of known signal evolutions to determine tissue properties of the subject, and generating a report indicating the tissue properties of the subject.

公开(公告)号：US10459055B2

公开(公告)日：2019-10-29

申请号：US15945594

申请日：2018-04-04

申请人： Case Western Reserve University

发明人： Mark A. Griswold ,  Yun Jiang

IPC分类号： G01R33/561 ,  G01R33/56 ,  G01R33/50 ,  G06T7/00 ,  G01R33/483 ,  G01R33/54

摘要： The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of excitation volumes within a subject, wherein at least two of the plurality of excitation volumes differ in location within the subject, and wherein each of the excitation volumes partially overlap to form an overlap volume. The method also includes comparing the plurality of MRF signals acquired from the overlap volume with a dictionary of signal evolutions, determining one or more physical parameters of the overlap volume within the subject, and generating a report at least indicating the one or more physical parameters of the overlap volume within the subject.

公开(公告)号：US10261154B2

公开(公告)日：2019-04-16

申请号：US14257081

申请日：2014-04-21

申请人： Case Western Reserve University

发明人： Mark Griswold ,  Yun Jiang ,  Dan Ma ,  Anagha Deshmane ,  Chaitra Badve ,  Vikas Gulani ,  Jeffrey L Sunshine

IPC分类号： G06K9/00 ,  G01R33/56 ,  G01R33/48 ,  G01R33/50

摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The NMR signal evolution may be assigned to a cluster based on the characterization of the resonant species. Cluster overlay maps may be produced simultaneously based, at least in part, on the clustering. The clusters may be associated with different tissue types.

公开(公告)号：US09625540B2

公开(公告)日：2017-04-18

申请号：US14024915

申请日：2013-09-12

申请人： Case Western Reserve University

发明人： Mark Griswold ,  Yun Jiang ,  Dan Ma

IPC分类号： G01R33/28 ,  G01R33/48 ,  G01R33/56

CPC分类号： G01R33/283 ,  G01R33/4828 ,  G01R33/56

摘要： Apparatus, methods, and other embodiments associated with optimizing sounds produced during nuclear magnetic resonance (NMR) fingerprinting are described. One example NMR apparatus includes an NMR logic to repetitively and variably sample a (k, t, E) space associated with a patient to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The parameters are varied in different acquisition blocks to facilitate matching sounds produced in response to the acquisition blocks to a desired set of sounds. The desired set of sounds may be a musical piece.

公开(公告)号：US09568579B2

公开(公告)日：2017-02-14

申请号：US14024999

申请日：2013-09-12

申请人： Case Western Reserve University

发明人： Renate Jerecic ,  Mark Griswold ,  Yun Jiang ,  Dan Ma

IPC分类号： G01V3/00 ,  G01R33/56 ,  G01R33/561 ,  G01R33/50

CPC分类号： G01R33/56 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/561

摘要： Apparatus, methods, and other embodiments associated with nuclear magnetic resonance (NMR) fingerprinting using echo splitting are described. One example apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include the number of echo splitting pulses, spacings between echo splitting pulses, flip angle of echo splitting pulses, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals.

摘要翻译： 描述了使用回波分裂与核磁共振（NMR）指纹相关联的装置，方法和其它实施例。 一个示例性装置包括NMR逻辑，其被配置为重复和可变地采样与对象相关联的（k，t，E）空间以获取一组NMR信号。 一组NMR信号的成员与（k，t，E）空间中的不同点相关联。 t和/或E以非常数方式变化进行采样。 变化的参数可以包括回波分离脉冲的数量，回波分裂脉冲之间的间隔，回波分裂脉冲的翻转角，回波时间，RF振幅以及其它参数。 NMR装置还可以包括被配置为从NMR信号产生NMR信号演化的信号逻辑，以及被配置为通过将获取的信号与参考信号进行比较的结果来表征对象中的共振物种的表征逻辑。

公开(公告)号：US20150301138A1

公开(公告)日：2015-10-22

申请号：US14682183

申请日：2015-04-09

申请人： Case Western Reserve University

发明人： Mark Griswold ,  Yun Jiang ,  Dan Ma

IPC分类号： G01R33/50 ,  G01R33/565 ,  G01R33/44 ,  G01R33/48

CPC分类号： A61B5/0263 ,  A61B1/00 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/742 ,  A61B17/00 ,  A61B2217/00 ,  A61B2218/00 ,  G01R1/00 ,  G01R33/448 ,  G01R33/4818 ,  G01R33/4828 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5608 ,  G01R33/5611 ,  G01R33/56366 ,  G01R33/56563 ,  G06T1/00 ,  G06T2200/00

摘要： Example embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. Sampling is performed in response to a fast imaging with steady state free precession (MRF-FISP) pulse sequence having an unbalanced gradient that dephases transverse magnetization. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The unbalanced gradient in the MRF-FISP pulse sequence reduces sensitivity to B0 in homogeneity.

摘要翻译： 描述与NMR指纹图谱相关联的示例实施例。 一个例子的NMR装置包括NMR逻辑，其重复和可变地采样与物体相关联的（k，t，E）空间，以获得与（k，t，E）空间中的不同点相关联的一组NMR信号。 t和/或E以非常数方式变化进行采样。 响应于具有不平衡梯度的稳态自由进动（MRF-FISP）脉冲序列的快速成像来执行取样，其消除横向磁化强度。 NMR装置还可以包括从NMR信号产生NMR信号演化的信号逻辑，以及作为将获取的信号与参考信号进行比较的结果来表征物体中的共振物种的表征逻辑。 MRF-FISP脉冲序列中的不平衡梯度降低了均匀性对B0的敏感性。

公开(公告)号：US10281547B2

公开(公告)日：2019-05-07

申请号：US14257207

申请日：2014-04-21

申请人： Case Western Reserve University

发明人： Mark Griswold ,  Vikas Gulani ,  Dan Ma ,  Yun Jiang ,  Katherine Wright

IPC分类号： G01R33/56 ,  G01R33/48 ,  G01R33/36 ,  G06T7/00 ,  G01R33/563

摘要： Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. Sampling is performed in response to a diffusion-weighted double-echo pulse sequence. Sampling acquires transient-state signals of the double-echo sequence. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals.

公开(公告)号：US20180292493A1

公开(公告)日：2018-10-11

申请号：US15945594

申请日：2018-04-04

申请人： Case Western Reserve University

发明人： Mark A. Griswold ,  Yun Jiang

IPC分类号： G01R33/561 ,  G01R33/56 ,  G01R33/54 ,  G01R33/50 ,  G06T7/00

CPC分类号： G01R33/561 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/543 ,  G01R33/56 ,  G06T7/0012 ,  G06T2207/10088

摘要： The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of excitation volumes within a subject, wherein at least two of the plurality of excitation volumes differ in location within the subject, and wherein each of the excitation volumes partially overlap to form an overlap volume. The method also includes comparing the plurality of MRF signals acquired from the overlap volume with a dictionary of signal evolutions, determining one or more physical parameters of the overlap volume within the subject, and generating a report at least indicating the one or more physical parameters of the overlap volume within the subject.