公开(公告)号：US20090264783A1

公开(公告)日：2009-10-22

申请号：US12106043

申请日：2008-04-18

申请人： Cecilia Qin Xi ,  Cem Shaquer

发明人： Cecilia Qin Xi ,  Cem Shaquer

IPC分类号： A61B5/0456

CPC分类号： A61B5/046

摘要： Methods and systems described herein are especially useful wherein monitoring for atrial fibrillation (AF) is based on RR interval variability as measured from an electrocardiogram (ECG) signal. An activity threshold, which can be patient specific, is obtained. Patient activity is monitored. Based on the monitored patient activity and the activity threshold, there is a determination of when it is likely that AF monitoring based on RR interval variability is adversely affected by patient activity. When it has been determined that it is likely that AF monitoring based on RR interval variability is adversely affected by patient activity, whether and/or how AF monitoring is performed is modified.

摘要翻译： 本文所述的方法和系统特别有用，其中监测心房颤动（AF）是基于从心电图（ECG）信号测量的RR间期变异性。 获得可以是患者特异性的活动阈值。 监测患者活动。 根据监测的患者活动和活动阈值，确定何时可能基于RR间期差异的AF监测受到患者活动的不利影响。 当确定可能基于RR间期变异性的AF监测受到患者活动的不利影响时，是否修改和/或如何进行AF监视。

公开(公告)号：US09320448B2

公开(公告)日：2016-04-26

申请号：US12106043

申请日：2008-04-18

申请人： Cecilia Qin Xi ,  Cem Shaquer

发明人： Cecilia Qin Xi ,  Cem Shaquer

IPC分类号： A61B5/0456 ,  A61B5/046

CPC分类号： A61B5/046

摘要： Methods and systems described herein are especially useful wherein monitoring for atrial fibrillation (AF) is based on RR interval variability as measured from an electrocardiogram (ECG) signal. An activity threshold, which can be patient specific, is obtained. Patient activity is monitored. Based on the monitored patient activity and the activity threshold, there is a determination of when it is likely that AF monitoring based on RR interval variability is adversely affected by patient activity. When it has been determined that it is likely that AF monitoring based on RR interval variability is adversely affected by patient activity, whether and/or how AF monitoring is performed is modified.

摘要翻译： 本文所述的方法和系统特别有用，其中监测心房颤动（AF）是基于从心电图（ECG）信号测量的RR间期变异性。 获得可以是患者特异性的活动阈值。 监测患者活动。 根据监测的患者活动和活动阈值，确定何时可能基于RR间期差异的AF监测受到患者活动的不利影响。 当确定可能基于RR间期变异性的AF监测受到患者活动的不利影响时，是否修改和/或如何进行AF监视。

公开(公告)号：US09037236B2

公开(公告)日：2015-05-19

申请号：US13537757

申请日：2012-06-29

申请人： Cecilia Qin Xi ,  Lanitia Ness ,  Stuart Rosenberg

发明人： Cecilia Qin Xi ,  Lanitia Ness ,  Stuart Rosenberg

IPC分类号： A61N1/36 ,  A61N1/365 ,  A61B5/0452 ,  A61N1/362 ,  A61B5/0468 ,  A61B5/046

CPC分类号： A61N1/36592 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0468 ,  A61N1/36139 ,  A61N1/36142 ,  A61N1/36185 ,  A61N1/3621 ,  A61N1/36585

摘要： Methods and systems are provided to control a configuration of a neural stimulation (NS) system having an NS device coupled to an NS lead. The methods and systems change between configurations of the NS system and collect cardiac signals from a patient that are representative of cardiac rhythms experienced by the patient over a period of time and in connection with multiple NS configurations. The methods and systems derive, from the cardiac signals, characteristic values for at least one physiologic characteristic indicative of at least one of normal and abnormal cardiac rhythms in connection with the multiple NS configurations; and select, from the multiple NS configurations, an NS operating configuration to be used by the NS system based on the characteristic values.

摘要翻译： 提供了方法和系统来控制具有与NS引线相连的NS器件的神经刺激（NS）系统的配置。 所述方法和系统在NS系统的配置之间改变，并且收集来自患者的心脏信号，所述心脏信号代表患者经历一段时间并与多个NS配置相关的心脏节律。 所述方法和系统从心脏信号中导出与多个NS构型有关的指示正常和异常心律中的至少一个的至少一个生理特征的特征值; 并从多个NS配置中选择要由NS系统基于特征值使用的NS操作配置。

公开(公告)号：US20130261473A1

公开(公告)日：2013-10-03

申请号：US13432977

申请日：2012-03-28

申请人： Cecilia Qin Xi ,  Yasser Sowb

发明人： Cecilia Qin Xi ,  Yasser Sowb

IPC分类号： A61B5/04 ,  A61B5/0215 ,  A61N1/365

CPC分类号： A61N1/3702 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/1118 ,  A61N1/08 ,  A61N1/365 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37 ,  A61N1/37241 ,  A61N1/37247

摘要： Methods, systems and devices efficiently identify cardiac resynchronization therapy (CRT) pacing parameter set(s) that provide improved hemodynamic response relative to an initial CRT pacing parameter set, wherein each CRT pacing parameter set includes at least two CRT pacing parameters. User input(s) are accepted that specify a maximum amount of time and/or parameter sets that can be used to perform testing, and specify relative importance of parameters within the sets. Based on the accepted user input(s), there is a determination of how many different variations of each of the CRT pacing parameters can be tested, and based on this determination different CRT pacing parameter sets are selected and tested to obtain a hemodynamic response measure corresponding to each of the different sets tested. Additionally, one or more of the tested CRT pacing parameter sets, if any, that provide improved hemodynamic response relative to the initial CRT pacing parameter set is/are identified.

摘要翻译： 方法，系统和设备有效地识别相对于初始CRT起搏参数组提供改善的血液动力学响应的心脏再同步治疗（CRT）起搏参数组，其中每个CRT起搏参数组包括至少两个CRT起搏参数。 接受用户输入，指定可用于执行测试的最大时间量和/或参数集，并指定集合内参数的相对重要性。 基于所接受的用户输入，确定可以测试每个CRT起搏参数的多少不同变化，并且基于该确定来选择和测试不同的CRT起搏参数组以获得血液动力学响应测量 对应于每个不同的测试集。 另外，确定提供相对于初始CRT起搏参数组改善的血液动力学响应的一个或多个经测试的CRT起搏参数组（如果有的话）。

公开(公告)号：US20110319957A1

公开(公告)日：2011-12-29

申请号：US12823870

申请日：2010-06-25

申请人： Mihir Naware ,  Cecilia Qin Xi

发明人： Mihir Naware ,  Cecilia Qin Xi

IPC分类号： A61N1/08

CPC分类号： A61B5/0538 ,  A61N1/37 ,  A61N2001/083

摘要： Testing lead conditions in an implantable medical device includes continuously sampling the impedance values of a lead associated with the implantable medical device. The sampling is conducted over a predetermined period of time. An impedance histogram is then generated using the sampled impedance values by separating each measured impedance value into a specific bin assigned to contain a particular range of impedance levels. The lead condition of the tested lead can then be determined based on one or more characteristics of the impedance histogram.

摘要翻译： 在可植入医疗装置中测试引导条件包括连续取样与可植入医疗装置相关的引线的阻抗值。 采样在预定的时间段内进行。 然后使用采样的阻抗值，通过将每个测量的阻抗值分成分配给包含特定阻抗水平范围的特定箱体来产生阻抗直方图。 然后可以基于阻抗直方图的一个或多个特性来确定测试引线的引导条件。

公开(公告)号：US08843197B2

公开(公告)日：2014-09-23

申请号：US13049774

申请日：2011-03-16

申请人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Jong Gill ,  Brian Jeffrey Wenzel ,  Yelena Nabutovsky ,  William Hsu

发明人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Jong Gill ,  Brian Jeffrey Wenzel ,  Yelena Nabutovsky ,  William Hsu

IPC分类号： A61N1/365 ,  A61B5/02 ,  A61B5/042 ,  A61N1/362

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/042 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： A method for trending heart failure measures cardiogenic impedance (CI) and obtains signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the signals and applies the correction factors to the contractility estimates. A system for trending heart failure includes a contractility module to determine contractility estimates from CI measurements taken along at least a first vector through a heart, and a collection module to receive signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The system further includes a factor module to identify correction factors based on the signals and a correction module to apply the correction factors to the contractility estimates.

摘要翻译： 用于趋势性心力衰竭的方法测量心源性阻抗（CI）并且获得当获得CI测量时表示心脏体积和心脏压力中的至少一个的估计或直接测量的信号。 该方法基于信号识别校正因子，并将修正因子应用于收缩率估计。 用于趋向心力衰竭的系统包括收缩模块，用于根据通过心脏的至少第一载体进行的CI测量来确定收缩性估计，以及收集模块，用于接收代表心脏体积和压力中的至少一个的估计或直接测量的信号 的CI测量值。 该系统还包括一个因素模块，用于基于信号识别校正因子，以及一个校正模块，以将校正因子应用于收缩性估计。

公开(公告)号：US20140005739A1

公开(公告)日：2014-01-02

申请号：US13537757

申请日：2012-06-29

申请人： Cecilia Qin Xi ,  Lanitia Ness ,  Stuart Rosenberg

发明人： Cecilia Qin Xi ,  Lanitia Ness ,  Stuart Rosenberg

IPC分类号： A61N1/365

CPC分类号： A61N1/36592 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0468 ,  A61N1/36139 ,  A61N1/36142 ,  A61N1/36185 ,  A61N1/3621 ,  A61N1/36585

摘要： Methods and systems are provided to control a configuration of a neural stimulation (NS) system having an NS device coupled to an NS lead. The methods and systems change between configurations of the NS system and collect cardiac signals from a patient that are representative of cardiac rhythms experienced by the patient over a period of time and in connection with multiple NS configurations. The methods and systems derive, from the cardiac signals, characteristic values for at least one physiologic characteristic indicative of at least one of normal and abnormal cardiac rhythms in connection with the multiple NS configurations; and select, from the multiple NS configurations, an NS operating configuration to be used by the NS system based on the characteristic values.

摘要翻译： 提供了方法和系统来控制具有与NS引线相连的NS器件的神经刺激（NS）系统的配置。 所述方法和系统在NS系统的配置之间改变，并且收集来自患者的心脏信号，所述心脏信号代表患者经历一段时间并与多个NS配置相关的心脏节律。 所述方法和系统从心脏信号中导出与多个NS构型有关的指示正常和异常心律中的至少一个的至少一个生理特征的特征值; 并从多个NS配置中选择要由NS系统基于特征值使用的NS操作配置。

公开(公告)号：US08543206B2

公开(公告)日：2013-09-24

申请号：US12823870

申请日：2010-06-25

申请人： Mihir Naware ,  Cecilia Qin Xi

发明人： Mihir Naware ,  Cecilia Qin Xi

IPC分类号： A61N1/08

CPC分类号： A61B5/0538 ,  A61N1/37 ,  A61N2001/083

摘要： Testing lead conditions in an implantable medical device includes continuously sampling the impedance values of a lead associated with the implantable medical device. The sampling is conducted over a predetermined period of time. An impedance histogram is then generated using the sampled impedance values by separating each measured impedance value into a specific bin assigned to contain a particular range of impedance levels. The lead condition of the tested lead can then be determined based on one or more characteristics of the impedance histogram.

摘要翻译： 在可植入医疗装置中测试引导条件包括连续取样与可植入医疗装置相关的引线的阻抗值。 采样在预定的时间段内进行。 然后使用采样的阻抗值，通过将每个测量的阻抗值分成分配给包含特定阻抗水平范围的特定箱体来产生阻抗直方图。 然后可以基于阻抗直方图的一个或多个特性来确定测试引线的引导条件。

公开(公告)号：US20120239104A1

公开(公告)日：2012-09-20

申请号：US13049774

申请日：2011-03-16

申请人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Jong Gill ,  Brian Jeffrey Wenzel ,  Yelena Nabutovsky ,  William Hsu

发明人： Stuart Rosenberg ,  Cecilia Qin Xi ,  Jong Gill ,  Brian Jeffrey Wenzel ,  Yelena Nabutovsky ,  William Hsu

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/042 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： A method is provided for trending heart failure based on heart contractility information comprises measuring cardiogenic impedance (CI) measurements along at least a first vector through a heart over a period of time. The method determines contractility estimates from the CI measurements, the contractility estimates relating to contractility of the heart. The method further obtains physiologic and/or surrogate signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the physiologic and/or surrogate signals and applies the correction factors to the contractility estimates to produce contractility trend values over the period of time. A system is provided for trending heart failure based on heart contractility information which comprises inputs to receive cardiogenic impedance (CI) measurements taken along at least a first vector through a heart over a period of time. The system includes a contractility module to determine contractility estimates from the CI measurements, the contractility estimates relating to contractility of the heart and a collection module to receive physiologic and/or surrogate signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. A factor module is also provided to identify correction factors based on the physiologic and/or surrogate signals and a correction module to apply the correction factors to the contractility estimates to produce contractility trend values over the period of time.

摘要翻译： 提供了一种基于心脏收缩性信息来趋向于心力衰竭的方法，包括在一段时间内通过心脏沿着至少第一载体测量心源阻抗（CI）测量。 该方法确定CI测量的收缩性估计值，与心脏收缩性相关的收缩性估计值。 当获得CI测量时，该方法进一步获得表示心脏体积和心脏压力中的至少一个的估计值或直接测量值的生理和/或替代信号。 该方法基于生理和/或替代信号识别校正因子，并将修正因子应用于收缩性估计以产生一段时间内的收缩趋势值。 提供了一种用于基于心脏收缩性信息来趋向心力衰竭的系统，其包括用于在一段时间内通过心脏沿着至少第一载体进行的心源阻抗（CI）测量的输入。 该系统包括收缩性模块，用于根据CI测量值确定收缩性估计值，与心脏的收缩性相关的收缩性估计值以及收集模块以接收表示心脏体积和/或心脏容积中的至少一个的估计值或/或直接测量值的生理和/或替代信号， 获得CI测量时心脏的压力。 还提供了一个因素模块，用于根据生理和/或替代信号识别校正因子，以及校正模块，以将修正因子应用于收缩性估计，以产生一段时间内的收缩趋势值。

公开(公告)号：US08249707B2

公开(公告)日：2012-08-21

申请号：US12120471

申请日：2008-05-14

申请人： Yelena Nabutovsky ,  Rafael Donnay ,  Cecilia Qin Xi

发明人： Yelena Nabutovsky ,  Rafael Donnay ,  Cecilia Qin Xi

IPC分类号： A61N1/37

CPC分类号： A61N1/3622 ,  A61N1/3624

摘要： A non-implanted system receives, from an implantable cardiac device implanted within a patient, data corresponding to detected potential episodes of tachycardia. A representation of the data corresponding to the detected potential episodes of tachycardia is displayed to a user, and the user that observes the displayed representation of the data is allowed to enter a user diagnosis for each of the detected potential episodes of tachycardia. The non-implanted system simulates how the implantable cardiac device can use its discriminators to produce device diagnoses, based on the data for the detected potential episodes of tachycardia, including how adjustments to the discriminators affect how the device diagnoses match the user diagnoses. Thereafter, the non-implanted system can reprogram the implantable cardiac device to increase a likelihood that future device diagnoses produced by the implantable cardiac device would more closely match future user diagnoses produced by the user.

摘要翻译： 非植入系统从植入在患者体内的可植入心脏装置接收对应于检测到的心动过速潜在发作的数据。 与检测到的心动过速潜在发作相对应的数据的表示被显示给用户，并且观察所显示的数据表示的用户被允许针对每个检测到的心动过速的潜在发作进入用户诊断。 非植入系统模拟植入式心脏装置如何使用其鉴别器来产生装置诊断，基于检测到的心动过速的潜在发作的数据，包括如何对辨识器的调整影响装置诊断如何匹配用户诊断。 此后，非植入系统可重新编程可植入的心脏装置以增加由可植入心脏装置产生的未来设备诊断将更紧密地匹配用户产生的未来用户诊断的可能性。