公开(公告)号：US20200299672A1

公开(公告)日：2020-09-24

申请号：US16799464

申请日：2020-02-24

Applicant: Cellular Research, Inc.

Inventor： Philipp Spuhler ,  Sixing Li ,  Dennis Prosen

IPC: C12N15/10

Abstract: Disclosed herein include systems, apparatuses, devices, and methods for introducing one or more components into a fluid. A first fluid and a second fluid can be co-injected into a fluidic channel of a flow cell. In some embodiments, the first fluid and a second fluid are immiscible (e.g. an aqueous buffer and a non-aqueous liquid). In some embodiments, the second fluid is less dense than the first fluid.

公开(公告)号：US20180200710A1

公开(公告)日：2018-07-19

申请号：US15868811

申请日：2018-01-11

Applicant: Cellular Research, Inc.

Inventor： Philipp Spuhler ,  Sixing Li

IPC: B01L3/00 ,  C12N15/10 ,  G01N15/10

Abstract: Disclosed herein are methods, devices, and systems for efficient loading and retrieval of particles. In some embodiments, a fluidic channel of a flowcell comprises a ceiling, a first sidewall, and a bottom, wherein the contact angle of the ceiling is at least 10 degrees smaller than the contact angle of the first sidewall, and wherein the bottom of the fluidic channel comprises a substrate that comprises a plurality of microwells.

公开(公告)号：US10722880B2

公开(公告)日：2020-07-28

申请号：US15868811

申请日：2018-01-11

Applicant: Cellular Research, Inc.

Inventor： Philipp Spuhler ,  Sixing Li

IPC: B01L3/00 ,  C12N15/10 ,  G01N15/10 ,  C12Q1/6874 ,  G01N15/14 ,  C12Q1/6869 ,  C12N15/09 ,  C12Q1/68

Abstract: Disclosed herein are methods, devices, and systems for efficient loading and retrieval of particles. In some embodiments, a fluidic channel of a flowcell comprises a ceiling, a first sidewall, and a bottom, wherein the contact angle of the ceiling is at least 10 degrees smaller than the contact angle of the first sidewall, and wherein the bottom of the fluidic channel comprises a substrate that comprises a plurality of microwells.

公开(公告)号：US20240263165A1

公开(公告)日：2024-08-08

申请号：US18627190

申请日：2024-04-04

Applicant: Cellular Research, Inc.

Inventor： Philipp Spuhler ,  Sixing Li ,  Dennis E. Prosen

IPC: C12N15/10 ,  B01L3/00

CPC classification number: C12N15/1003 ,  B01L3/5027

Abstract: Disclosed herein include systems, apparatuses, devices, and methods for introducing one or more components into a fluid. A first fluid and a second fluid can be co-injected into a fluidic channel of a flow cell. In some embodiments, the first fluid and a second fluid are immiscible (e.g. an aqueous buffer and a non-aqueous liquid). In some embodiments, the second fluid is less dense than the first fluid.

公开(公告)号：US11976269B2

公开(公告)日：2024-05-07

申请号：US16799464

申请日：2020-02-24

Applicant: Cellular Research, Inc.

Inventor： Philipp Spuhler ,  Sixing Li ,  Dennis Prosen

IPC: C12Q1/68 ,  C12N15/10 ,  B01L3/00

CPC classification number: C12N15/1003 ,  B01L3/5027

Abstract: Disclosed herein include systems, apparatuses, devices, and methods for introducing one or more components into a fluid. A first fluid and a second fluid can be co-injected into a fluidic channel of a flow cell. In some embodiments, the first fluid and a second fluid are immiscible (e.g. an aqueous buffer and a non-aqueous liquid). In some embodiments, the second fluid is less dense than the first fluid.