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公开(公告)号：US20210355205A1
公开(公告)日：2021-11-18
申请号：US17385532
申请日：2021-07-26
Applicant: Cephalon, Inc.
Inventor： Mark Terence Liddament , Anthony Doyle , Adam Clarke , David Jose Simon Laine , Bridget Ann Cooksey
Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
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Patent Agency Ranking
公开(公告)号：US20200040089A1
公开(公告)日：2020-02-06
申请号：US16527354
申请日：2019-07-31
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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公开(公告)号：US11332534B2
公开(公告)日：2022-05-17
申请号：US16527354
申请日：2019-07-31
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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公开(公告)号：US11111292B2
公开(公告)日：2021-09-07
申请号：US15848090
申请日：2017-12-20
Applicant: Cephalon, Inc.
Inventor： Mark Terence Liddament , Anthony Doyle , Adam Clarke , David Jose Simon Laine , Bridget Ann Cooksey
Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
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公开(公告)号：US20220348671A1
公开(公告)日：2022-11-03
申请号：US17718622
申请日：2022-04-12
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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公开(公告)号：US20180186873A1
公开(公告)日：2018-07-05
申请号：US15848090
申请日：2017-12-20
Applicant: Cephalon, Inc.
Inventor： Mark Terence Liddament , Anthony Doyle , Adam Clarke , David Jose Simon Laine , Bridget Ann Cooksey
IPC: C07K16/24
Abstract: Disclosed herein are fully human antibody molecules that immunospecifically bind to human IL-5. The antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM as determined by surface plasmon resonance.
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