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公开(公告)号：US20200040089A1
公开(公告)日：2020-02-06
申请号：US16527354
申请日：2019-07-31
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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公开(公告)号：US11332534B2
公开(公告)日：2022-05-17
申请号：US16527354
申请日：2019-07-31
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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公开(公告)号：US20220348671A1
公开(公告)日：2022-11-03
申请号：US17718622
申请日：2022-04-12
Applicant: Cephalon, Inc.
Inventor： Doris Shim Siew Chen , Lynn Dorothy Poulton , Adam Clarke , David Jose Simon Laine , Matthew Pollard , Bridget Ann Cooksey , Anthony Doyle , Jason William Gill
Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.
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