公开(公告)号：US08323673B2

公开(公告)日：2012-12-04

申请号：US13289794

申请日：2011-11-04

申请人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

发明人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

IPC分类号： A01N25/02 ,  A01N43/40

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3544 ,  Y02A50/486 ,  A01N31/02 ,  A01N25/30 ,  A01N25/02 ,  A01N2300/00

摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

摘要翻译： 公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。 稀释的QAC溶液可用于食品，以防止食物中的微生物生长受到广泛的食源性微生物污染。 还公开了使食品与稀释的QAC接触至少0.1秒的施用时间的方法。 可以通过这种方法处理的食物是肉类和肉制品，海产品，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以被处理的食物，仍然保持其外观和质感。 其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

公开(公告)号：US20090239912A1

公开(公告)日：2009-09-24

申请号：US12475760

申请日：2009-06-01

申请人： CESAR COMPADRE ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

发明人： CESAR COMPADRE ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

IPC分类号： A01N43/40

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3544 ,  Y02A50/486 ,  A01N31/02 ,  A01N25/30 ,  A01N25/02 ,  A01N2300/00

摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

摘要翻译： 公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。 稀释的QAC溶液用于接触食品，以防止食品中的微生物生长受到广泛的食源性微生物污染。 公开了一种将食品与稀释的QAC接触至少0.1秒的施用时间的方法。 可以通过这种方法处理的食物是肉类和肉制品，海鲜，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以处理，仍然保持其外观和质感的食物。 其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

公开(公告)号：US20120071521A1

公开(公告)日：2012-03-22

申请号：US13289794

申请日：2011-11-04

申请人： Cesar COMPADRE ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

发明人： Cesar COMPADRE ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

IPC分类号： A01N43/40 ,  A01P1/00 ,  A01N33/12

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3544 ,  Y02A50/486 ,  A01N31/02 ,  A01N25/30 ,  A01N25/02 ,  A01N2300/00

摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

摘要翻译： 公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。 稀释的QAC溶液可用于食品，以防止食物中的微生物生长受到食源性微生物污染的广泛影响。 还公开了使食品与稀释的QAC接触至少0.1秒的施用时间的方法。 可以通过这种方法处理的食物是肉类和肉制品，海产品，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以被处理的食物，仍然保持其外观和质感。 其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

公开(公告)号：US07541045B2

公开(公告)日：2009-06-02

申请号：US10943217

申请日：2004-09-17

申请人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

发明人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

IPC分类号： A01N25/02

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3544 ,  Y02A50/486 ,  A01N31/02 ,  A01N25/30 ,  A01N25/02 ,  A01N2300/00

摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

摘要翻译： 公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。 稀释的QAC溶液用于接触食品，以防止食品中的微生物生长受到广泛的食源性微生物污染。 公开了一种将食品与稀释的QAC接触至少0.1秒的施用时间的方法。 可以通过这种方法处理的食物是肉类和肉制品，海鲜，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以处理，仍然保持其外观和质感的食物。 其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

公开(公告)号：US06864269B2

公开(公告)日：2005-03-08

申请号：US09494374

申请日：2000-01-31

申请人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

发明人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien ,  Amy L. Waldroup ,  Thomas F. Berg

IPC分类号： A01N25/02 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3526 ,  A61K31/14 ,  A61K31/44

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3544 ,  Y02A50/486 ,  A01N31/02 ,  A01N25/30 ,  A01N25/02 ,  A01N2300/00

摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.

摘要翻译： 公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。 稀释的QAC溶液用于接触食品，以防止食品中的微生物生长受到广泛的食源性微生物污染。 公开了一种将食品与稀释的QAC接触至少0.1秒的施用时间的方法。 可以通过这种方法处理的食物是肉类和肉制品，海鲜，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以处理，仍然保持其外观和质感的食物。 其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

公开(公告)号：US6039992A

公开(公告)日：2000-03-21

申请号：US840288

申请日：1997-04-14

申请人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien

发明人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny L. Lattin ,  Michael Slavik ,  Yanbin Li ,  Timothy O'Brien

IPC分类号： A23B4/08 ,  A23B4/20 ,  A23B4/30 ,  A23B7/153 ,  A23B7/154 ,  A23B7/158 ,  A23L3/349 ,  A23L3/3526 ,  A23L3/3544 ,  A01N43/40

CPC分类号： A23L3/3544 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3526

摘要： A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin-producing Escherichia, and pathogenic toxin-producing Escherichia, such as 0157:H7; fungi, such as Aspergillus flavus and Penicillium chrysogenum; and parasites, such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit. One of the treatment methods is spraying quaternary ammonium compounds on the food products to prevent broad spectrum foodborne microbial contamination. New formulations of quaternary ammonium compounds combined with glycerin and/or ethyl alcohol provides a concentrated formulation for industrial use and a diluted formulation for use in spraying methods.

摘要翻译： 一种使用季铵化合物抑制食品中多种食源性微生物污染的附着和去除的方法。 该方法使用季铵化合物抑制葡萄球菌，弯曲杆菌，解酒杆菌，李斯特菌，气单胞菌，芽孢杆菌，沙门氏菌，产生非毒素的大肠杆菌和产生致病性毒素的大肠杆菌，如0157：H7的微生物的附着和除去。 真菌，如黄曲霉和产黄青霉; 和寄生虫，例如从广泛的食物中组织溶解葡萄球菌（Entameba histolytica）。 可以通过这种方法处理的食物是肉，海鲜，蔬菜和水果。 一种处理方法是在食品上喷洒季铵化合物，以防止广谱食源性微生物污染。 与甘油和/或乙醇结合的季铵化合物的新配方提供工业用浓缩制剂和用于喷雾方法的稀释制剂。

公开(公告)号：US5855940A

公开(公告)日：1999-01-05

申请号：US631578

申请日：1996-04-12

申请人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny Lattin ,  Mike Slavik ,  Yanbin Li

发明人： Cesar Compadre ,  Philip Breen ,  Hamid Salari ,  E. Kim Fifer ,  Danny Lattin ,  Mike Slavik ,  Yanbin Li

IPC分类号： A23B4/08 ,  A23B4/20 ,  A23B4/30 ,  A23B7/153 ,  A23B7/154 ,  A23B7/158 ,  A23L3/349 ,  A23L3/3526 ,  A23L3/3544 ,  A01N43/40

CPC分类号： A23L3/3544 ,  A23B4/20 ,  A23B4/30 ,  A23B7/154 ,  A23B7/158 ,  A23L3/3526

摘要： A composition and a method of using the composition for removal and prevention of broad spectrum foodborne microbial contamination in meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from poultry and meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing Escherichia coli O157:H7 contamination from meat and poultry products. One of the treatment methods is spraying quaternary ammonium compounds on the poultry and meat products to prevent broad spectrum foodborne microbial contamination. The treatment methods can contact the meat products with the quaternary ammonium compounds for less than 10 minutes and still obtain significant reduction of viable foodborne microorganisms. New formulations of quaternary ammonium compounds combined with glycerin and/or ethyl alcohol provides a concentrated formulation for industrial use and a more viscous formulation for use in spraying methods.

摘要翻译： 一种组合物和使用该组合物去除和预防肉类产品中广谱食源性微生物污染的组合物和方法。 该方法使用季铵化合物来抑制家禽和肉制品中的广泛的食源性微生物污染的附着和去除。 该方法使用季铵化合物抑制肉和禽类产品的大肠杆菌O157：H7污染的附着和去除。 一种处理方法是将季铵化合物喷洒在家禽和肉类产品上，以防止广谱食源性微生物污染。 处理方法可以将肉类产品与季铵化合物接触少于10分钟，并且可以显着降低活的食源性微生物。 与甘油和/或乙醇结合的季铵化合物的新配方提供了用于工业用途的浓缩制剂和用于喷雾方法的更粘稠的制剂。

公开(公告)号：US5366983A

公开(公告)日：1994-11-22

申请号：US863445

申请日：1992-04-03

申请人： Danny L. Lattin ,  Philip J. Breen ,  Cesar M. Compadre ,  E. Kim Fifer ,  Michael F. Slavik ,  Hamid Salari ,  Phillip V. Engler

发明人： Danny L. Lattin ,  Philip J. Breen ,  Cesar M. Compadre ,  E. Kim Fifer ,  Michael F. Slavik ,  Hamid Salari ,  Phillip V. Engler

IPC分类号： A01N33/12 ,  A01N43/40 ,  A23B4/20 ,  A23L3/3526

CPC分类号： A23L3/3526 ,  A01N33/12 ,  A01N43/40 ,  A23B4/20

摘要： A composition and method for removing and preventing Salmonella contamination of meat products, in particular poultry. The composition comprises an effective amount of a quaternary ammonium compound in an aqueous solution. The quaternary ammonium compound are selected from the group consisting of alkylpyridinium, tetra-alkylammonium, and alkylalicyclic ammonium salts. Preferably, the quaternary ammonium compounds are cetylpyridinium chloride (CPC) and cetylpyridinium bromide (CPB). The method comprises treating meat and poultry products with an effective amount of the quaternary ammonium compound in an aqueous solution. Mutagenicity studies are also disclosed.

摘要翻译： 用于去除和预防肉制品特别是家禽的沙门氏菌污染的组合物和方法。 组合物在水溶液中包含有效量的季铵化合物。 季铵化合物选自烷基吡啶鎓，四烷基铵和烷基脂环族铵盐。 优选地，季铵化合物是氯化十六烷基吡啶（CPC）和溴化十六烷基吡啶（CPB）。 该方法包括在水溶液中用有效量的季铵化合物处理肉和禽产品。 还公开了致突变性研究。

公开(公告)号：US06407107B1

公开(公告)日：2002-06-18

申请号：US09579602

申请日：2000-05-26

申请人： Kathleen Gilbert ,  E. Kim Fifer

发明人： Kathleen Gilbert ,  E. Kim Fifer

IPC分类号： A61K315375

CPC分类号： C07D295/185 ,  C07C219/06 ,  C07D211/46 ,  C07D295/088 ,  C07D295/13

摘要： The present invention provides a series of compounds having structural formulas wherein n1 is 1 to 5, n2 is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R′ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n1 is not 1; and wherein X and R′ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in an individual.

摘要翻译： 本发明提供一系列具有结构式的化合物，其中n1为1至5，n2为1至4，m为1至3; X是O或NH; Y是CH 2，O，S，NH，NR; R选自直链脂族基团，支链脂族基团和脂环族基团; 其中R'选自氢，甲基和乙基; 当Y为O时，n1不为1; 并且其中X和R'独立地任选地被取代在C 3或C 4的化合物或其药学上可接受的盐的化合物中。 还提供了灭活个体中的抗原特异性T细胞的方法。

公开(公告)号：US07034020B2

公开(公告)日：2006-04-25

申请号：US10734919

申请日：2003-12-12

申请人： Kathleen Gilbert ,  E. Kim Fifer

发明人： Kathleen Gilbert ,  E. Kim Fifer

IPC分类号： A61K31/5375 ,  C07D295/15 ,  A61P43/00

CPC分类号： C07D295/185 ,  C07C219/06 ,  C07D211/46 ,  C07D295/088 ,  C07D295/13

摘要： The present invention provides a series of compounds having structural formulas wherein n1 is 1 to 5, n2 is 1 to 4 and m is 1 to 3; X is O or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein R′ is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n1 is not 1; and wherein X and R′ are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in a n individual.

摘要翻译： 本发明提供一系列具有结构式的化合物，其中n 1为1至5，n 2为1至4，m为1至3; X是O或NH; Y是CH 2，O，S，NH，NR; R选自直链脂族基团，支链脂族基团和脂环族基团; 其中R'选自氢，甲基和乙基; 当Y为O时，n 1不为1; 并且其中X和R'独立地任选地被取代在C 3或C 4的化合物或其药学上可接受的盐的化合物中。 还提供了灭活个体中的抗原特异性T细胞的方法。