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1.发明申请HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS 有权组胺脱乙酰酶抑制剂及其合成方法及其在制药中的应用公开(公告)号：US20140243501A1
公开(公告)日：2014-08-28
申请号：US13980308
申请日：2012-02-23
申请人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
发明人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
IPC分类号： C07K5/097
CPC分类号： C07K5/0821 , A61K38/06 , C07F7/10 , C07F7/1804 , Y02A50/411
摘要： The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要翻译： 本发明提供如式I所示的组蛋白脱乙酰酶（HDAC）抑制剂，其中R1至R8如说明书中所定义。 本发明还提供了这些化合物的合成方法和这些化合物在制备用于预防或治疗与HDAC失调相关的哺乳动物疾病的药物中的应用。
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2.发明授权Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments 有权组蛋白脱乙酰酶抑制剂及其合成方法及其在药物制造中的应用公开(公告)号：US08933195B2
公开(公告)日：2015-01-13
申请号：US13980308
申请日：2012-02-23
申请人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
发明人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
CPC分类号： C07K5/0821 , A61K38/06 , C07F7/10 , C07F7/1804 , Y02A50/411
摘要： The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要翻译： 本发明提供如式I所示的组蛋白脱乙酰酶（HDAC）抑制剂，其中R1至R8如说明书中所定义。 本发明还提供了这些化合物的合成方法和这些化合物在制备用于预防或治疗与HDAC失调相关的哺乳动物疾病的药物中的应用。
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公开(公告)号：USD1049124S1
公开(公告)日：2024-10-29
申请号：US29839353
申请日：2022-05-20
申请人： Feng Zhang
设计人： Feng Zhang
摘要： FIG. 1 is a perspective view of a mouse mover showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof; and,
FIG. 8 is a rear side perspective view thereof.
The broken lines in the drawings depict portions of the mouse mover that form no part of the claimed design.-
公开(公告)号：US20240304619A1
公开(公告)日：2024-09-12
申请号：US18181155
申请日：2023-03-09
申请人： Guowei Xu , Chiao-Ti Huang , Robin Chao , Tao Chu , Feng Zhang , Yang Zhang , Biswajeet Guha , Oleg Golonzka
发明人： Guowei Xu , Chiao-Ti Huang , Robin Chao , Tao Chu , Feng Zhang , Yang Zhang , Biswajeet Guha , Oleg Golonzka
IPC分类号： H01L27/088 , H01L21/8234 , H01L29/06 , H01L29/417 , H01L29/66 , H01L29/778 , H01L29/78
CPC分类号： H01L27/0886 , H01L21/823431 , H01L29/0665 , H01L29/41791 , H01L29/66795 , H01L29/778 , H01L29/7851
摘要： An IC device includes a backside FTI separating a first transistor from a second transistor. The FTI may be between a source region of the first transistor and a drain region of the second transistor. The source region of the first transistor and the drain region of the second transistor may be different portions of a semiconductor structure, e.g., a fin or nanoribbon. The IC device may also include a frontside metal layer. The semiconductor structure may have a first surface and a second surface opposing the first surface. The first surface of the semiconductor structure may be closer to the metal layer and larger than the second surface of the semiconductor structure. The FTI may have a first surface and a second surface opposing the first surface. The first surface of the FTI may be closer to the metal layer but smaller than the second surface of the FTI.
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5.发明授权公开(公告)号：US11408978B2
公开(公告)日：2022-08-09
申请号：US16871006
申请日：2020-05-10
申请人： Fengyu Wang , Beibei Wang , Chenshu Wu , Feng Zhang , K. J. Ray Liu , Oscar Chi-Lim Au
发明人： Fengyu Wang , Beibei Wang , Chenshu Wu , Feng Zhang , K. J. Ray Liu , Oscar Chi-Lim Au
摘要： Methods, apparatus and systems for wireless vital signs monitoring are described. In one embodiment, a described system comprises: a transmitter, a receiver, a processor. The transmitter transmits, using N1 transmit antennas, a wireless signal through a wireless multipath channel of a venue, while a first object in the venue is having a first repetitive motion. The receiver receives, using N2 receive antennas, the wireless signal through the wireless multipath channel, and extracts a plurality of time series of channel information (TSCI) of the wireless multipath channel from the wireless signal. N1 and N2 are positive integers. Each of the plurality of TSCI is associated with a transmit antenna of the transmitter and a receive antenna of the receiver. The processor computes a first information of the first repetitive motion based on the plurality of TSCI, and monitors the first repetitive motion of the first object based on the first information.
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公开(公告)号：US20210215789A1
公开(公告)日：2021-07-15
申请号：US17214841
申请日：2021-03-27
申请人： Yuqian Hu , Beibei Wang , Muhammed Zahid Ozturk , Feng Zhang , K. J. Ray Liu , Oscar Chi-Lim Au , Xiaolu Zeng , Chenshu Wu , Fengyu Wang
发明人： Yuqian Hu , Beibei Wang , Muhammed Zahid Ozturk , Feng Zhang , K. J. Ray Liu , Oscar Chi-Lim Au , Xiaolu Zeng , Chenshu Wu , Fengyu Wang
摘要： Methods, apparatus and systems for wireless proximity sensing are described. In one example, a described system comprises: a transmitter configured for transmitting a first wireless signal through a wireless multipath channel of a venue; a receiver configured for receiving a second wireless signal through the wireless multipath channel; and a processor. The second wireless signal differs from the first wireless signal due to the wireless multipath channel that is impacted by a movement of an object in the venue. The processor is configured for: obtaining a time series of channel information (TSCI) of the wireless multipath channel based on the second wireless signal, wherein each channel information (CI) of the TSCI comprises a plurality of CI components, each of which is associated with an index; computing an inter-component statistics based on the plurality of CI components; computing, based on the inter-component statistics, a proximity information of the object with respect to a reference location in the venue; and performing a task based on the proximity information of the object.
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公开(公告)号：US11012285B2
公开(公告)日：2021-05-18
申请号：US16127151
申请日：2018-09-10
申请人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
发明人： Chen Chen , Beibei Wang , Yi Han , Feng Zhang , Hung-Quoc Duc Lai , Yan Chen , K. J. Ray Liu , Oscar Chi-Lim Au
摘要： The present teaching relates to vital sign detection and monitoring based on channel state information (CSI). In one example, an apparatus for vital sign detection is disclosed. The apparatus comprises a receiver, a processor and a memory communicatively coupled with the processor. The receiver is configured for receiving at least one wireless signal from a multipath channel that can be impacted by a vital sign of at least one living being. The processor is configured for: extracting a time series of channel state information (CSI) for the multipath channel from the at least one wireless signal, obtaining one or more periodic fluctuations based on a spectral analysis of the time series of CSI, and determining whether the vital sign is present based on the one or more periodic fluctuations.
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公开(公告)号：US09603848B2
公开(公告)日：2017-03-28
申请号：US11760592
申请日：2007-06-08
申请人： Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
发明人： Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
IPC分类号： A61K31/495 , A61K31/517 , A61K31/519 , C07D239/80 , C07D239/95 , C07D239/96 , C07D285/15 , C07D487/04 , C07D491/04 , G01N33/74 , G06F19/16 , G06F19/18
CPC分类号： A61K31/495 , A61K31/517 , A61K31/519 , C07D239/80 , C07D239/95 , C07D239/96 , C07D285/15 , C07D487/04 , C07D491/04 , G01N33/74 , G01N2333/726 , G01N2500/04 , G06F19/16 , G06F19/18
摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
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公开(公告)号：US09370551B2
公开(公告)日：2016-06-21
申请号：US13557988
申请日：2012-07-25
申请人： Le Cong , Ann Marie Egloff , Levi A. Garraway , Jennifer Rubin Grandis , Eric S. Lander , Nicholas Stransky , Aaron D. Tward , Feng Zhang
发明人： Le Cong , Ann Marie Egloff , Levi A. Garraway , Jennifer Rubin Grandis , Eric S. Lander , Nicholas Stransky , Aaron D. Tward , Feng Zhang
IPC分类号： C12N15/85 , A61K38/16 , A61K38/46 , A61K45/06 , C07K14/47 , C12N9/22 , C12N15/90 , A61K48/00
CPC分类号： A61K38/164 , A61K38/465 , A61K45/06 , A61K48/005 , C07K14/4703 , C07K14/4705 , C07K2319/00 , C07K2319/70 , C07K2319/71 , C07K2319/80 , C12N9/22 , C12N15/907 , C12N2710/20011 , C12N2800/22 , C12N2999/007
摘要： The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.
摘要翻译： 本发明提供了与头颈鳞状细胞癌（HNSCC）及其相关的恶化前病变相关的方法。 特别地，本发明的特征在于可以特异性靶向HNSCC相关基因并改变基因表达以治疗或缓解HNSCC或其相关的恶化前病变的症状的方法。 这些方法可能涉及降低具有异常增殖功能的HNSCC相关基因的功能; 或增加具有异常功能丧失的HNSCC相关基因的功能。
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公开(公告)号：US09238150B2
公开(公告)日：2016-01-19
申请号：US12185624
申请日：2008-08-04
CPC分类号： A61N5/0622 , A61K36/05 , A61K38/16 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651 , C12N7/00 , C12N2710/10043 , C12N2710/16643 , G06F19/00
摘要： In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
摘要翻译： 在一个实例中，系统使用由光纤布置提供的细长结构，调制电路和光通路电刺激活动物体的靶细胞。 细长结构用于插入到动物中的狭窄通道中，使得细长结构的端部足够靠近靶细胞以向其施加刺激。 调制电路用于在细长结构处于窄通道中时调制靶细胞，其中调制电路适于通过细长结构递送病毒载体，用于在靶细胞中表达光响应蛋白。 光通路用于通过将光传递到靶细胞中的光响应蛋白来刺激靶细胞。
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