公开(公告)号：US07652773B2

公开(公告)日：2010-01-26

申请号：US10586713

申请日：2005-01-20

申请人： Charles A. DiMarzio ,  Ronald A. Roy ,  Todd W. Murray ,  Florian J. Blonigen ,  Luis A. Nieva ,  Lei Sui ,  Gopi Maguluri

发明人： Charles A. DiMarzio ,  Ronald A. Roy ,  Todd W. Murray ,  Florian J. Blonigen ,  Luis A. Nieva ,  Lei Sui ,  Gopi Maguluri

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  G01N29/0672 ,  G01N29/2418 ,  G01N29/346 ,  G01N2291/02466 ,  G01N2291/02872 ,  G01N2291/0427

摘要： A system and method of detecting acousto-photonic emissions in optically turbid media that provide increased levels of detection sensitivity. The detection system includes an ultrasonic transducer, a laser, a photo-detector for detecting ultrasound-modulated laser light, and circuitry for processing the detected signals for subsequent analysis. The ultrasonic transducer generates an ultrasonic wave that propagates within an optically turbid medium. The laser generates a coherent light beam, which is split to form signal and reference beams. The signal beam is sent through the turbid medium, where it is phase modulated by the ultrasound. The ultrasound-modulated signal beam is provided to a photo-refractive crystal for subsequent interference with the reference beam to convert the phase modulation to intensity modulation. The DC offset of the signal beam intensity provides a measure of the magnitude of the mean phase shift induced by the ultrasound on the multiply scattered optical field within the turbid medium.

摘要翻译： 一种在光学混浊介质中检测声光发射的系统和方法，其提供更高水平的检测灵敏度。 检测系统包括超声波换能器，激光器，用于检测超声调制激光的光检测器，以及用于处理检测信号以用于后续分析的电路。 超声波换能器产生在光学混浊介质内传播的超声波。 激光产生相干光束，其被分离以形成信号和参考光束。 信号光束通过混浊介质传送，在那里它被超声波相位调制。 超声调制信号光束被提供给光折射晶体，用于随后与参考光束的干涉，以将相位调制转换成强度调制。 信号光束强度的直流偏移提供了在混浊介质内的多重散射光场上由超声引起的平均相移幅度的量度。

公开(公告)号：US20080094633A1

公开(公告)日：2008-04-24

申请号：US10586713

申请日：2005-01-20

申请人： Charles A. Dimarzio ,  Ronald A. Roy ,  Todd W. Murray ,  Florian J. Blonigen ,  Luis A. Nieva

发明人： Charles A. Dimarzio ,  Ronald A. Roy ,  Todd W. Murray ,  Florian J. Blonigen ,  Luis A. Nieva

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  G01N29/0672 ,  G01N29/2418 ,  G01N29/346 ,  G01N2291/02466 ,  G01N2291/02872 ,  G01N2291/0427

摘要： A system and method of detecting acousto-photonic emissions in optically turbid media that provide increased levels of detection sensitivity. The detection system includes an ultrasonic transducer, a laser, a photo-detector for detecting ultrasound-modulated laser light, and circuitry for processing the detected signals for subsequent analysis. The ultrasonic transducer generates an ultrasonic wave that propagates within an optically turbid medium. The laser generates a coherent light beam, which is split to form signal and reference beams. The signal beam is sent through the turbid medium, where it is phase modulated by the ultrasound. The ultrasound-modulated signal beam is provided to a photo-refractive crystal for subsequent interference with the reference beam to convert the phase modulation to intensity modulation. The DC offset of the signal beam intensity provides a measure of the magnitude of the mean phase shift induced by the ultrasound on the multiply scattered optical field within the turbid medium.

摘要翻译： 一种在光学混浊介质中检测声光发射的系统和方法，其提供更高水平的检测灵敏度。 检测系统包括超声波换能器，激光器，用于检测超声调制激光的光检测器，以及用于处理检测信号以用于后续分析的电路。 超声波换能器产生在光学混浊介质内传播的超声波。 激光产生相干光束，其被分离以形成信号和参考光束。 信号光束通过混浊介质传送，在那里它被超声波相位调制。 超声调制信号光束被提供给光折射晶体，用于随后与参考光束的干涉，以将相位调制转换为强度调制。 信号光束强度的直流偏移提供了在混浊介质内的多重散射光场上由超声引起的平均相移幅度的量度。

公开(公告)号：US07792570B2

公开(公告)日：2010-09-07

申请号：US11101111

申请日：2005-04-07

申请人： Charles A. DiMarzio ,  Luis A. Nieva

发明人： Charles A. DiMarzio ,  Luis A. Nieva

IPC分类号： A61B6/00

CPC分类号： A61B5/0048 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0095 ,  A61B5/441

摘要： A microscopy apparatus includes a heating source to provide a pulse of heating energy focused on a target to heat a localized region of the target, such as human tissue, to generate motion. A measuring source provides a measuring light beam focused on the target. A coherent confocal microscopy assembly focuses the measuring light beam on the target and returns a reflected signal from the target. A detection assembly receives the reflected signal from the target and detects a Doppler shift of the reflected signal. A scanning assembly scans pulses from the heating source over the target and scans the measuring light beam from the measuring source over the target to build up an image of a plane of the target.

摘要翻译： 显微镜装置包括加热源，以提供聚焦在靶上的加热能量的脉冲，以加热诸如人体组织的靶的局部区域，以产生运动。 测量源提供聚焦在目标上的测量光束。 相干共焦显微镜组件将测量光束聚焦在目标上，并从目标返回反射信号。 检测组件从目标接收反射信号并检测反射信号的多普勒频移。 扫描组件从目标上的加热源扫描脉冲，并从目标上的测量源扫描测量光束，以建立目标平面的图像。