-
1.发明授权Acrylic and propionic acid compounds, intermediates, processes, compositions, and method 失效丙烯酸和丙酸化合物，中间体，方法，组合物和方法公开(公告)号：US06350884B1
公开(公告)日：2002-02-26
申请号：US08940785
申请日：1997-09-30
IPC分类号： C07D33360
CPC分类号： C07D333/60
摘要： This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation of the acrylic and propionic acid compounds.
摘要翻译： 本发明涉及一类丙烯酸和丙酸化合物及其在治疗绝经后症状和再狭窄中的用途。 在其它实施方案中，本发明涉及中间体和制备丙烯酸和丙酸化合物的方法。
-
2.发明授权Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods 失效丙烯酸和丙酸化合物，中间体，方法，组合物和方法公开(公告)号：US06440958B1
公开(公告)日：2002-08-27
申请号：US08673702
申请日：1996-06-25
IPC分类号： A61K31381
CPC分类号： C07D333/60 , C07D333/56
摘要： This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation of the acrylic and propionic acid compounds.
摘要翻译： 本发明涉及一类丙烯酸和丙酸化合物及其在治疗绝经后症状和再狭窄中的用途。 在其它实施方案中，本发明涉及中间体和制备丙烯酸和丙酸化合物的方法。
-
公开(公告)号：US5856339A
公开(公告)日：1999-01-05
申请号：US552679
申请日：1995-11-03
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , A61K31/445 , C07D409/12
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： The present invention provides intermediate compounds and processes for the preparation of compounds of formula I ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供中间体化合物及其制备方法，其中R 1a为-H或-OR 7a，其中R 7a为-H或羟基保护基; R2a是-H，卤素或-OR8a，其中R8a是-H或羟基保护基; R3是1-哌啶基，1-吡咯烷子基，甲基-1-吡咯烷基，二甲基-1-吡咯烷子基，4-吗啉代，二甲基氨基，二乙基氨基，二异丙基氨基或1-六亚甲基亚氨基; n为2或3; Z为-O-或-S-; 或其药学上可接受的盐。
-
4.发明授权Benzothiophene compounds, intermediates, processes, compositions, and methods 失效苯并噻吩化合物，中间体，方法，组合物和方法
公开(公告)号：US6075151A
公开(公告)日：2000-06-13
申请号：US138789
申请日：1998-08-24
IPC分类号： A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4433 , A61K31/445 , A61K31/4535 , A61K31/535 , A61K31/55 , A61P3/06 , A61P9/00 , A61P15/08 , A61P19/10 , A61P43/00 , C07D333/66 , C07D409/12 , C07D333/72
CPC分类号： C07D333/66
摘要： The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.
摘要翻译： 本发明提供苯并噻吩化合物，制剂和抑制骨丢失或骨吸收，特别是骨质疏松症的心血管相关病理状况，包括高脂血症和其它心血管病变的方法。
-
公开(公告)号：US5986109A
公开(公告)日：1999-11-16
申请号：US100179
申请日：1998-06-18
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , C07D333/56
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： A compound of fomula XIV: ##STR1## wherein: R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is a hydoxy protecting group;R.sup.2a is --H, halo, or OR.sup.8a in which R.sup.8a is a hydroxy protecting group; andR.sup.9 is a leaving group;or a pharmaceutically acceptable salt thereof
摘要翻译： 化合物XIV：其中：R 1a是-H或-OR 7a，其中R 7a是羟基保护基; R2a是-H，卤素或OR8a，其中R8a是羟基保护基; R9为离去基团; 或其药学上可接受的盐
-
公开(公告)号：US06265575B1
公开(公告)日：2001-07-24
申请号：US09369416
申请日：1999-08-05
IPC分类号： C07D40912
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译： 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物，其制备方法和中间体，以及包含式I化合物的药物制剂。
-
公开(公告)号：US5981765A
公开(公告)日：1999-11-09
申请号：US99789
申请日：1998-06-18
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , C07D333/56
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： The present invention provides a compound of formula ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is a hydroxy protecting group;R.sup.6 is --H or a hydroxy protecting group which can be selectively removed;R.sup.11 is non-existent or .dbd.O; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供下式化合物其中R 1a是-H或-OR 7a，其中R 7a是羟基保护基; R2a是-H，卤素或-OR8a，其中R8a是羟基保护基; R6是-H或可选择性除去的羟基保护基; R11不存在或= O; Z为-O-或-S-; 或其药学上可接受的盐。
-
公开(公告)号：US06992097B2
公开(公告)日：2006-01-31
申请号：US10453833
申请日：2003-06-03
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： A61K31/415 , C07D233/44
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
-
公开(公告)号：US06639076B1
公开(公告)日：2003-10-28
申请号：US09762529
申请日：2001-04-17
申请人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人： Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号： C07D40112
CPC分类号： C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要： This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
摘要翻译： 本发明涉及式I的新化合物，其中A，B，D，E，G，J，L，X，V如说明书中所定义，并且该化合物可用于调节哺乳动物内源性生长激素水平。
-
公开(公告)号：US5969142A
公开(公告)日：1999-10-19
申请号：US99785
申请日：1997-06-18
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , C07D409/12 , A61K31/445
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： The present invention provides compounds and processes for the preparation of compounds of formula I ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, duisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof, throughreduction of an intermediate of formula XVI ##STR2##
摘要翻译： 本发明提供化合物及其制备方法，其中R1a是-H或-OR7a，其中R7a是-H或羟基保护基; R2a是-H，卤素或-OR8a，其中R8a是-H或羟基保护基; R3是1-哌啶基，1-吡咯烷子基，甲基-1-吡咯烷基，二甲基-1-吡咯烷子基，4-吗啉代，二甲基氨基，二乙基氨基，二异丙基氨基或1-六亚甲基亚氨基; n为2或3; Z为-O-或-S-; 或其药学上可接受的盐，通过还原式ⅩⅥ的中间体
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.062 秒)
