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27 条记录 (耗时 0.018 秒)

    Novel tricyclic indole compound
    7.
    发明授权
    Novel tricyclic indole compound 失效

    公开(公告)号：US5030646A

    公开(公告)日：1991-07-09

    申请号：US446034

    申请日：1989-12-05

    申请人： Charles Malen ,  Jean-Michel Lacoste ,  Michel Laubie

    发明人： Charles Malen ,  Jean-Michel Lacoste ,  Michel Laubie

    IPC分类号： A61K31/40 ,  A61P1/08 ,  A61P9/00 ,  A61P25/04 ,  A61P25/20 ,  A61P25/28 ,  A61P43/00 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted with one or more halogen atoms,X denotes a hydrogen atom, a linear or branched lower alkyl group or a group SO.sub.2 E in which E denotes a linear or branched lower alkyl group or an aryl group optionally substituted with a linear or branched lower alkyl group,T denotes a hydrogen atom or a lower alkyl group,R.sub.3 denotes a hydrogen atom or a linear or branched lower alkyl group or an aryl group optionally substituted with one or more linear or branched lower alkyl groups,n and m, which may be identical or different, each denote 0 or 1,R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group,or alternatively,R.sup.1 and R.sup.2 form, together with the nitrogen atom to which they are linked, a saturated or unsaturated, mono- or bicyclic nitrogenous heterocyclic system, each ring being 5- or 6-membered and optionally comprising one or two other hetero atoms selected from nitrogen, oxygen or sulfur, and optionally substituted with one or more linear or branched lower alkyl or alkoxy groups or with an aryl group which is itself optionally substituted with one or more lower alkyl, lower alkoxy or trifluoromethyl groups or alternatively one or more halogen atoms,or alternatively,R.sup.1 denotes a group ##STR2## in which R.sub.4, R.sub.5 and R.sub.6, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group, or alternatively R.sub.4 forms with R.sub.5 a bridge (CH.sub.2).sub.p, p being between 2 and 4, or alternatively R.sub.1 denotes a dibenzo[a,d]cyclohept-5-yl group and R.sub.2 denotes a hydrogen atom, where appropriate, their isomers and also their addition salts with a pharmaceutically acceptable acid. Medicinal products.

    Acylaminophenol compounds
    8.
    发明授权
    Acylaminophenol compounds 失效
    酰氨基苯酚化合物

    公开(公告)号：US5254590A

    公开(公告)日：1993-10-19

    申请号：US847599

    申请日：1992-03-05

    申请人： Charles Malen ,  Jean-Michel Lacoste ,  Jean-Paul Vilaine ,  Albert Lenaers

    发明人： Charles Malen ,  Jean-Michel Lacoste ,  Jean-Paul Vilaine ,  Albert Lenaers

    IPC分类号： A61K31/165 ,  A61P3/06 ,  A61P9/10 ,  C07C231/14 ,  C07C233/25 ,  C07C233/26 ,  C07C233/27 ,  C07C233/60 ,  A01N37/22 ,  A01N37/18

    CPC分类号： C07C233/26 ,  C07C233/25 ,  C07C233/27 ,  C07C2101/08

    摘要： The invention relates to the compounds of formula (I): ##STR1## in which R represents higher alkyl, 1-(higher alkyl)lower cycloalkyl-1-yl or higher alkenyl comprising one or more double bonds, and eitherR.sub.3 represents hydroxyl,R.sub.1 and R.sub.2, which are different, represent hydrogen or lower alkyl,R.sub.4 and R.sub.5, which are identical or different, represent lower alkyl or alkoxy, orR.sub.1 and R.sub.4 represent hydroxyl andR.sub.2, R.sub.3 and R.sub.5, which are identical or different, represent lower alkyl or alkoxy,their isomers as well as their salts, and a method for treating an animal or human living body afflicted with dylipidemias or atherosclerosis.

    摘要翻译： 本发明涉及式（I）化合物：其中R表示高级烷基，1-（高级烷基）低级环烷基-1-基或含有一个或多个双键的更高级链烯基，R3或R3 表示羟基，不同的R 1和R 2表示氢或低级烷基，R 4和R 5相同或不同，表示低级烷基或烷氧基，或者R 1和R 4表示羟基，R 2，R 3和R 5是相同或 不同的，代表低级烷基或烷氧基，它们的异构体及其盐，以及用于治疗患有血脂异常或动脉粥样硬化的动物或人类活体的方法。

    Tricyclic ethers, their preparation and the pharmaceutical compositions containing them
    10.
    发明授权
    Tricyclic ethers, their preparation and the pharmaceutical compositions containing them 失效
    三环醚，它们的制备和含有它们的药物组合物

    公开(公告)号：US4496557A

    公开(公告)日：1985-01-29

    申请号：US408451

    申请日：1982-08-16

    申请人： Charles Malen ,  Jean-Claude Poignant

    发明人： Charles Malen ,  Jean-Claude Poignant

    IPC分类号： A61K31/00 ,  A61P25/20 ,  C07D267/18 ,  C07D311/80 ,  C07D313/12 ,  A61K31/33 ,  A61K31/335

    CPC分类号： C07D313/12 ,  C07D267/18 ,  C07D311/80

    摘要： Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.

    摘要翻译： 相应于下列通式的化合物：其中X和Y相同或不同，表示氢或卤素原子，低级烷基，低级烷氧基或三氟甲基，A表示亚甲基，直接 键或其中R 3为氢原子或低级烷基或低级烷酰基的亚氨基-NR 3 - 基团，R 1和R 2相同或不同，各自表示氢原子或低级烷基，或与氮原子一起 附着它们形成吡咯烷子基，哌啶子基或甲基-4-哌嗪基团，n表示1至3的整数，以其外消旋或旋光异构体形式，以及其与治疗相容的矿物或有机酸的加成盐。 这些化合物可用作抗抑郁药。