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公开(公告)号：US4092423A
公开(公告)日：1978-05-30
申请号：US723684
申请日：1976-09-16
IPC分类号： C07D207/08 , C07D211/34 , C07D211/60 , C07D295/15 , C07D207/04 , A61K31/40
CPC分类号： C07D295/15 , C07D207/08 , C07D211/34 , C07D211/60
摘要： This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.
摘要翻译： 本发明涉及具有被氨基低级烷基羧酸残基取代的氨基的邻烷氧基苯胺，以及它们的生理上相容的酸加成盐及其光学活性异构体。
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2.发明授权Alkoxy anilides process for preparing the same and pharmaceutical compositions 失效用于制备相同药物组合物的烷氧基苯胺方法
公开(公告)号：US4070485A
公开(公告)日：1978-01-24
申请号：US723685
申请日：1976-09-16
IPC分类号： C07D207/08 , C07D211/34 , C07D211/60 , C07D295/15 , C07C103/44
CPC分类号： C07D295/15 , C07D207/08 , C07D211/34 , C07D211/60
摘要： This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.
摘要翻译： 本发明涉及具有被氨基低级烷基羧酸残基取代的氨基的邻烷氧基苯胺，以及它们的生理上相容的酸加成盐及其光学活性异构体。
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公开(公告)号：US3989834A
公开(公告)日：1976-11-02
申请号：US558043
申请日：1975-03-13
IPC分类号： A61K31/165 , A61K31/275 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/535 , A61P1/04 , A61P1/14 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C237/04 , C07D207/08 , C07D207/09 , C07D211/34 , C07D211/60 , C07D295/15 , C07D211/06
CPC分类号： C07D207/08 , C07D211/34 , C07D211/60 , C07D295/15 , Y10S514/925
摘要： This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.
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4.发明授权Benzylamino alkanoic acid derivatives, using compositions containing the same, and methods for utilizing said derivatives and compositions 失效苄基氨基链烷酸衍生物，使用含有它们的组合物，以及利用所述衍生物和组合物的方法
公开(公告)号：US4154851A
公开(公告)日：1979-05-15
申请号：US776893
申请日：1977-03-11
IPC分类号： C07D295/185 , C07C87/00 , C07C101/00
CPC分类号： C07D295/185
摘要： This invention relates to novel .omega.-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers.They are produced by condensing an oxoalkanoic acid with a benzylamine under reducing conditions.This invention also relates to .omega.-benzylamino alkanoic amides and to .omega.-benzylamino alkanoic acid esters.They have therapeutical use, namely in the psychotherapeutical field. They are utilized in the form of pharmaceutical compositions.
摘要翻译： 本发明涉及新的ω-苄基氨基链烷酸，它们与有机或矿物碱或与有机或无机酸形成的盐。 这些链烷酸可以是外消旋形式或分解成它们的光学活性对映异构体。
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公开(公告)号：US4048321A
公开(公告)日：1977-09-13
申请号：US685756
申请日：1976-05-13
IPC分类号： C07D209/44 , C07D209/52 , A61K31/40 , C07D207/12
CPC分类号： C07D209/52 , C07D209/44 , Y10S514/872
摘要： Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
摘要翻译： 下式的二取代氮杂双环烷烃其中：
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6.发明授权
公开(公告)号：US4048313A
公开(公告)日：1977-09-13
申请号：US540032
申请日：1975-01-09
IPC分类号： C07D295/22 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/04 , A61P21/02 , A61P25/00 , C07C67/00 , C07C301/00 , C07C303/38 , C07C303/40 , C07C311/46 , C07D211/60 , C07D295/26 , C07D295/00
CPC分类号： C07D295/26 , C07D211/60 , Y10S514/872 , Y10S514/926 , Y10S514/927
摘要： This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.
摘要翻译： 本申请涉及苯磺酰胺，更具体地涉及1-酰氨基2-烷氧基或烯丙氧基-5-吗啉基磺酰基苯及其与矿物或有机酸的盐。 它还涉及生产这些化合物的方法。
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公开(公告)号：US3972994A
公开(公告)日：1976-08-03
申请号：US525623
申请日：1974-11-20
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61P1/08 , A61P9/12 , B01J21/00 , B01J25/00 , C07B61/00 , C07D209/44 , C07D209/52
CPC分类号： C07D209/44 , C07D209/52
摘要： Disubstituted azabicycloalkanes of the formula ##SPC1##Wherein:n is 0, 1 or 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
摘要翻译： 下式的二取代的氮杂双环烷烃：
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8.发明授权
公开(公告)号：US4066662A
公开(公告)日：1978-01-03
申请号：US755476
申请日：1976-12-30
IPC分类号： C07D209/44 , C07D209/52 , A61K31/40
CPC分类号： C07D209/52 , C07D209/44 , Y10S514/926
摘要： Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
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公开(公告)号：US4042598A
公开(公告)日：1977-08-16
申请号：US685757
申请日：1976-05-13
IPC分类号： C07D209/44 , C07D209/52
CPC分类号： C07D209/44 , C07D209/52
摘要： Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
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10.发明授权Tricyclic ethers, their preparation and the pharmaceutical compositions containing them 失效三环醚，它们的制备和含有它们的药物组合物
公开(公告)号：US4496557A
公开(公告)日：1985-01-29
申请号：US408451
申请日：1982-08-16
IPC分类号： A61K31/00 , A61P25/20 , C07D267/18 , C07D311/80 , C07D313/12 , A61K31/33 , A61K31/335
CPC分类号： C07D313/12 , C07D267/18 , C07D311/80
摘要： Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.
摘要翻译： 相应于下列通式的化合物：其中X和Y相同或不同，表示氢或卤素原子，低级烷基，低级烷氧基或三氟甲基，A表示亚甲基，直接 键或其中R 3为氢原子或低级烷基或低级烷酰基的亚氨基-NR 3 - 基团，R 1和R 2相同或不同，各自表示氢原子或低级烷基，或与氮原子一起 附着它们形成吡咯烷子基，哌啶子基或甲基-4-哌嗪基团，n表示1至3的整数，以其外消旋或旋光异构体形式，以及其与治疗相容的矿物或有机酸的加成盐。 这些化合物可用作抗抑郁药。
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