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27 条记录 (耗时 0.036 秒)

    Tricyclic ethers, their preparation and the pharmaceutical compositions containing them
    6.
    发明授权
    Tricyclic ethers, their preparation and the pharmaceutical compositions containing them 失效
    三环醚，它们的制备和含有它们的药物组合物

    公开(公告)号：US4496557A

    公开(公告)日：1985-01-29

    申请号：US408451

    申请日：1982-08-16

    申请人： Charles Malen ,  Jean-Claude Poignant

    发明人： Charles Malen ,  Jean-Claude Poignant

    IPC分类号： A61K31/00 ,  A61P25/20 ,  C07D267/18 ,  C07D311/80 ,  C07D313/12 ,  A61K31/33 ,  A61K31/335

    CPC分类号： C07D313/12 ,  C07D267/18 ,  C07D311/80

    摘要： Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.

    摘要翻译： 相应于下列通式的化合物：其中X和Y相同或不同，表示氢或卤素原子，低级烷基，低级烷氧基或三氟甲基，A表示亚甲基，直接 键或其中R 3为氢原子或低级烷基或低级烷酰基的亚氨基-NR 3 - 基团，R 1和R 2相同或不同，各自表示氢原子或低级烷基，或与氮原子一起 附着它们形成吡咯烷子基，哌啶子基或甲基-4-哌嗪基团，n表示1至3的整数，以其外消旋或旋光异构体形式，以及其与治疗相容的矿物或有机酸的加成盐。 这些化合物可用作抗抑郁药。

    2-Amino oxazolines and process for making the same
    8.
    发明授权
    2-Amino oxazolines and process for making the same 失效
    2-氨基恶唑啉及其制备方法

    公开(公告)号：US4102890A

    公开(公告)日：1978-07-25

    申请号：US713381

    申请日：1976-08-11

    申请人： Charles Malen ,  Monique Desnos ,  Michel Laubie ,  Jean-Claude Poignant

    发明人： Charles Malen ,  Monique Desnos ,  Michel Laubie ,  Jean-Claude Poignant

    IPC分类号： C07C275/18 ,  C07D233/48 ,  C07D263/28 ,  C07D265/06 ,  C07D277/18

    CPC分类号： C07D265/06 ,  C07C275/18 ,  C07D233/48 ,  C07D263/28 ,  C07D277/18 ,  C07C2101/02

    摘要： Cyclopropylmethylamines which are substituted on the 2-position of nitrogen heterocycles so as to provide new compounds of the formula ##STR1## wherein A is oxygen, sulfur, or nitrogen; the other "R" variables in general are hydrogen, lower-alkyl, cyclopropyl, or lower-alkyl substituted cyclopropyl; and the n's are the numbers 0 to 3, inclusive, and acid addition salts thereof, are disclosed. The compounds are cardiovascular agents, which are depressive of the central nervous system. Their effects include hypnosis, analgesia, and neuro-modulation. They can be used as anti-hypertensive agents.

    摘要翻译： 在氮杂环的2位上被取代的环丙基甲基胺，以提供新的式I化合物，其中A是氧，硫或氮; 另一个“R”变量通常是氢，低级烷基，环丙基或低级烷基取代的环丙基; 并且n是数字0至3，包括它们的酸加成盐。 这些化合物是抑制中枢神经系统的心血管药物。 它们的作用包括催眠，镇痛和神经调节。 它们可以用作抗高血压药。