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公开(公告)号：US08431116B2
公开(公告)日：2013-04-30
申请号：US12816495
申请日：2010-06-16
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
摘要翻译： 本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白 更多的诺如病毒基因组。
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公开(公告)号：US20080299152A1
公开(公告)日：2008-12-04
申请号：US12093921
申请日：2007-09-28
IPC分类号： A61K39/125 , A61P31/14
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
摘要翻译： 本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白 更多的诺如病毒基因组。
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公开(公告)号：US20120156243A1
公开(公告)日：2012-06-21
申请号：US12816495
申请日：2010-06-16
IPC分类号： A61K39/125 , A61P31/14
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
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公开(公告)号：US07955603B2
公开(公告)日：2011-06-07
申请号：US12093921
申请日：2007-09-28
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
摘要翻译： 本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白 更多的诺如病毒基因组。
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5.发明授权Monoclonal antibody specific for the extracellular domain of prostate specific membrane antigen 有权特异于前列腺特异性膜抗原细胞外结构域的单克隆抗体公开(公告)号：US07476513B2
公开(公告)日：2009-01-13
申请号：US11150507
申请日：2005-06-09
IPC分类号： G01N33/574 , A61K38/00
CPC分类号： C07K16/28 , A61K49/0058 , A61K51/1027 , A61K51/1072 , C07K16/3069 , C07K2317/34 , C12N2799/026 , G01N33/57434
摘要： The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM′) of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.
摘要翻译： 本发明涉及结合前列腺特异性膜抗原（PSMA）的细胞外结构域的单克隆抗体，产生抗体的杂交瘤细胞系以及使用这种抗体诊断和治疗癌症的方法。 特别地，示例了在细胞表面上表达的与PSMA反应的三十五种单克隆抗体。 另外，本发明涉及由本发明的许多抗体检测的PSMA的新型蛋白质变体（PSM'）。 PSMA和PSM'的水解酶活性允许使用免疫酶测定法进行检测。
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