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公开(公告)号:US20120045436A1
公开(公告)日:2012-02-23
申请号:US13271143
申请日:2011-10-11
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92 , Y02A50/386
摘要: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.
摘要翻译: 公开了CD70结合剂,例如在表达CD70的细胞上发挥细胞毒性,细胞抑制或免疫调节的人源化抗CD70抗体和片段和衍生物,以及包含抗体,片段或衍生物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法,其包括对受试者施用CD70结合剂或药物组合物。
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公开(公告)号:US08067546B2
公开(公告)日:2011-11-29
申请号:US11912096
申请日:2006-04-19
CPC分类号: C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92 , Y02A50/386
摘要: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.
摘要翻译: 公开了CD70结合剂,例如在表达CD70的细胞上发挥细胞毒性,细胞抑制或免疫调节的人源化抗CD70抗体和片段和衍生物,以及包含抗体,片段或衍生物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法,其包括对受试者施用CD70结合剂或药物组合物。
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公开(公告)号:US08562987B2
公开(公告)日:2013-10-22
申请号:US13271143
申请日:2011-10-11
IPC分类号: A61K39/00
CPC分类号: C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92 , Y02A50/386
摘要: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.
摘要翻译: 公开了CD70结合剂,例如在表达CD70的细胞上发挥细胞毒性,细胞抑制或免疫调节的人源化抗CD70抗体和片段和衍生物,以及包含抗体,片段或衍生物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法,其包括对受试者施用CD70结合剂或药物组合物。
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公开(公告)号:US20090148942A1
公开(公告)日:2009-06-11
申请号:US11912096
申请日:2006-04-19
CPC分类号: C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92 , Y02A50/386
摘要: Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions.
摘要翻译: 公开了CD70结合剂,例如在表达CD70的细胞上发挥细胞毒性,细胞抑制或免疫调节的人源化抗CD70抗体和片段和衍生物,以及包含抗体,片段或衍生物的药物组合物和试剂盒。 还公开了用于治疗表达CD70的癌症和免疫学疾病的方法,其包括对受试者施用CD70结合剂或药物组合物。
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公开(公告)号:US20110312088A1
公开(公告)日:2011-12-22
申请号:US13109957
申请日:2011-05-17
申请人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
发明人: Charlotte McDonagh , Charles G. Cerveny , Dennis Benjamin , Paul Carter , Hans Peter Gerber , Leigh Francisco
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译: 本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。
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公开(公告)号:US07968687B2
公开(公告)日:2011-06-28
申请号:US12253895
申请日:2008-10-17
IPC分类号: C12P21/08
CPC分类号: A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423
摘要: This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease.
摘要翻译: 本发明涉及CD19结合剂和使用这种CD19结合剂治疗疾病的方法。
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公开(公告)号:US20100158909A1
公开(公告)日:2010-06-24
申请号:US12516914
申请日:2007-12-01
申请人: Charlotte McDonagh , Paul Carter , Django Sussman
发明人: Charlotte McDonagh , Paul Carter , Django Sussman
IPC分类号: A61K39/395 , C07K16/00 , A61P37/06
CPC分类号: A61K47/48561 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K51/1027 , A61K2039/505 , C07K16/2875 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.
摘要翻译: 本发明提供了与使用这种结合剂预防或治疗癌症和免疫学疾病有关的变体靶结合剂和方法。 变体靶结合剂与对靶细胞发挥细胞毒性,细胞抑制或免疫调节作用的治疗剂缀合。
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公开(公告)号:US08455622B2
公开(公告)日:2013-06-04
申请号:US12516914
申请日:2007-12-01
申请人: Charlotte McDonagh , Paul Carter , Django Sussman
发明人: Charlotte McDonagh , Paul Carter , Django Sussman
CPC分类号: A61K47/48561 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K51/1027 , A61K2039/505 , C07K16/2875 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: The present invention provides variant target binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of cancers and immunological disorders. The variant target binding agent is conjugated to a therapeutic agent that exerts a cytotoxic, cytostatic, or immunomodulatory effect on target cells.
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公开(公告)号:US20100239571A1
公开(公告)日:2010-09-23
申请号:US12438604
申请日:2007-08-24
申请人: Charlotte McDonagh , Paul Carter
发明人: Charlotte McDonagh , Paul Carter
CPC分类号: C07K16/2878 , A61K47/6811 , A61K47/6849 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要: This invention relates to CD30 binding agents and methods of using such binding agents for treating disease characterized by expression of CD30 antigen.
摘要翻译: 本发明涉及CD30结合剂和使用这种结合剂治疗特征在于表达CD30抗原的疾病的方法。
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公开(公告)号:US20080305044A1
公开(公告)日:2008-12-11
申请号:US11720244
申请日:2005-11-29
申请人: Charlotte McDonagh , Paul Carter
发明人: Charlotte McDonagh , Paul Carter
CPC分类号: C07K16/2878 , A61K47/6803 , A61K47/6849
摘要: Antibody drug conjugates with predetermined sites and stoichiometries of drug attachment are provided. Also provided are methods of using antibody drug conjugates.
摘要翻译: 提供了具有预定位点和药物附着化学计量的抗体药物偶联物。 还提供了使用抗体药物偶联物的方法。
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