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公开(公告)号：US11040960B2
公开(公告)日：2021-06-22
申请号：US16438880
申请日：2019-06-12
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61P11/00 , A61P37/00 , A61P17/06 , A61P35/00 , A61K31/4035 , A61K31/4439 , A61K45/06 , C07B59/00 , C07D405/14 , C07D413/12 , A61K31/422
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US11945805B2
公开(公告)日：2024-04-02
申请号：US17243872
申请日：2021-04-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/00 , C07D405/14 , C07D413/12
CPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/002 , C07D405/14 , C07D413/12 , C07B2200/05 , A61K31/4035 , A61K2300/00 , A61K31/422 , A61K2300/00 , A61K31/4439 , A61K2300/00
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10786494B2
公开(公告)日：2020-09-29
申请号：US16150796
申请日：2018-10-03
申请人： CHEMOCENTRYX, INC.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , C07D215/48 , C07D405/04 , C07D405/14 , A61K31/4709
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US10370363B2
公开(公告)日：2019-08-06
申请号：US15722785
申请日：2017-10-02
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： A61K45/06 , C07B59/00 , A61K31/422 , C07D405/12 , C07D405/14 , C07D413/12 , A61K31/4035 , A61K31/4439
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US20160340356A1
公开(公告)日：2016-11-24
申请号：US15158713
申请日：2016-05-19
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： C07D471/04 , C07D405/04 , A61K31/453 , A61K31/4725 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4545 , A61K31/496
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.
摘要翻译： 并且可用于药物组合物，用于治疗涉及CCR2受体的病理性激活的疾病和病症的方法。
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公开(公告)号：US12054484B2
公开(公告)日：2024-08-06
申请号：US17357427
申请日：2021-06-24
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： A61K31/35 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , A61K31/538 , A61K31/551 , A61K31/553 , A61K45/06 , A61P35/00 , A61P37/00 , C07D309/24 , C07D405/04 , C07D405/14 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , A61K31/538 , A61K31/551 , A61K31/553 , A61K45/06 , A61P35/00 , A61P37/00 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′):
and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.-
公开(公告)号：US11820759B2
公开(公告)日：2023-11-21
申请号：US17192810
申请日：2021-03-04
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
CPC分类号： C07D405/14 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , A61P35/00 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10266492B2
公开(公告)日：2019-04-23
申请号：US15659468
申请日：2017-07-25
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Jaroslaw Kalisiak , Antoni Krasinski , Rebecca M. Lui , Jay Powers , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D211/60
摘要： Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
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公开(公告)号：US11845729B2
公开(公告)日：2023-12-19
申请号：US17667289
申请日：2022-02-08
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Jaroslaw Kalisiak , Antoni Krasinski , Rebecca M. Lui , Jay Powers , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D211/60
CPC分类号： C07D211/60
摘要： Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
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