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公开(公告)号：US11945805B2
公开(公告)日：2024-04-02
申请号：US17243872
申请日：2021-04-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/00 , C07D405/14 , C07D413/12
CPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/002 , C07D405/14 , C07D413/12 , C07B2200/05 , A61K31/4035 , A61K2300/00 , A61K31/422 , A61K2300/00 , A61K31/4439 , A61K2300/00
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10744118B2
公开(公告)日：2020-08-18
申请号：US15074976
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Pingchen Fan , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang , Dean Dragoli
IPC分类号： A61K31/4178 , A61K31/4155 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04 , A61K31/4192 , A61K31/4196
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US10370363B2
公开(公告)日：2019-08-06
申请号：US15722785
申请日：2017-10-02
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： A61K45/06 , C07B59/00 , A61K31/422 , C07D405/12 , C07D405/14 , C07D413/12 , A61K31/4035 , A61K31/4439
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US09750722B2
公开(公告)日：2017-09-05
申请号：US14878784
申请日：2015-10-08
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Juan C. Jaen , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D233/88 , A61K31/437 , A61K31/4178 , A61K45/06 , C07D401/12 , A61K31/4155 , C07D231/40 , A61K31/4192 , A61K31/4196 , C07D471/04 , C07D403/12
CPC分类号： A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/437 , A61K45/06 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US11820759B2
公开(公告)日：2023-11-21
申请号：US17192810
申请日：2021-03-04
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
CPC分类号： C07D405/14 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , A61P35/00 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10759789B2
公开(公告)日：2020-09-01
申请号：US16524618
申请日：2019-07-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K31/404 , A61K31/4439 , C07D405/14 , C07D405/04 , C07D401/04 , C07D209/34 , A61P1/00 , A61P19/00 , A61P17/00 , A61P35/00 , A61P11/00
摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US10342781B2
公开(公告)日：2019-07-09
申请号：US15659488
申请日：2017-07-25
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Juan C. Jaen , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： A61K45/06 , A61K31/437 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US10421748B2
公开(公告)日：2019-09-24
申请号：US15914900
申请日：2018-03-07
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D209/34 , C07D405/04 , A61K31/404 , A61K31/4439 , C07D405/14 , C07D401/04
摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US10336736B2
公开(公告)日：2019-07-02
申请号：US15794800
申请日：2017-10-26
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K45/06 , A61K31/341 , A61K31/454 , A61K31/506 , C07D209/46 , C07D307/52 , C07D405/12 , C07D405/14 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/4725
摘要： Compounds are provided as chemokine inhibitors having the structure:
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