公开(公告)号：US20140296273A1

公开(公告)日：2014-10-02

申请号：US14191219

申请日：2014-02-26

申请人： Chen Yan ,  Jian-Dong Li ,  Bradford Berk ,  Kye-Im Jeon ,  Xiangbin Xu

发明人： Chen Yan ,  Jian-Dong Li ,  Bradford Berk ,  Kye-Im Jeon ,  Xiangbin Xu

IPC分类号： A61K31/4375

CPC分类号： A61K31/4375 ,  A61K9/0046 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

摘要： Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and methods include the use of vincamine or a vincamine derivative, either alone or in combination with one or more additional therapeutic agents, including a steroid (preferably a corticosteroid), an angiotensin II receptor (type 1) antagonist, an angiotensin-converting enzyme (ACE) inhibitor, and a non-steroidal anti-inflammatory drug.

摘要翻译： 公开了用于治疗或预防患者炎症状况的药物组合物和方法。 药物组合物和方法包括使用长春胺或长春胺衍生物，单独或与一种或多种另外的治疗剂组合使用，包括类固醇（优选皮质类固醇），血管紧张素II受体（1型）拮抗剂，血管紧张素 - 转化酶（ACE）抑制剂和非甾体抗炎药。

公开(公告)号：US20100221340A1

公开(公告)日：2010-09-02

申请号：US12678352

申请日：2008-09-16

申请人： Chen Yan ,  Jian-Dong Li ,  Bradford Berk ,  Kye-im Jeon ,  Xiangbin Xu

发明人： Chen Yan ,  Jian-Dong Li ,  Bradford Berk ,  Kye-im Jeon ,  Xiangbin Xu

IPC分类号： A61K9/14 ,  A61P29/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P3/10 ,  A61K31/573 ,  A61K31/4375

CPC分类号： A61K31/4375 ,  A61K9/0046 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

摘要： Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and methods include the use of vincamine or a vincamine derivative, either alone or in combination with one or more additional therapeutic agents, including a steroid (preferably a corticosteroid), an angiotensin II receptor (type 1) antagonist, an angiotensin-converting enzyme (ACE) inhibitor, and a non-steroidal anti-inflammatory drug.

摘要翻译： 公开了用于治疗或预防患者炎症状况的药物组合物和方法。 药物组合物和方法包括使用长春胺或长春胺衍生物，单独或与一种或多种另外的治疗剂组合使用，包括类固醇（优选皮质类固醇），血管紧张素II受体（1型）拮抗剂，血管紧张素 - 转化酶（ACE）抑制剂和非甾体抗炎药。

公开(公告)号：US20110190373A1

公开(公告)日：2011-08-04

申请号：US12991345

申请日：2009-05-05

申请人： Chen Yan ,  Jian-Dong Li

发明人： Chen Yan ,  Jian-Dong Li

IPC分类号： A61K31/475 ,  A61K31/7088 ,  A61K31/522 ,  A61P9/00

CPC分类号： A61K31/4745

摘要： The invention relates to methods of treating or preventing pathological cardiac remodeling and/or preventing heart failure. These methods include the administration of a PDE1 inhibitor to a patient under conditions effective to treat or prevent pathological cardiac remodeling, and therefore heart failure that occurs as a result of such remodeling. Pharmaceutical compositions and delivery vehicles that can be used in the methods of the present invention are also disclosed herein.

摘要翻译： 本发明涉及治疗或预防病理性心脏重塑和/或预防心力衰竭的方法。 这些方法包括在有效治疗或预防病理性心脏重塑的病症下向患者施用PDE1抑制剂，因此由于这种重塑而发生的心力衰竭。 可用于本发明方法的药物组合物和递送载体也在本文中公开。

公开(公告)号：US20090311791A1

公开(公告)日：2009-12-17

申请号：US12140291

申请日：2008-06-17

申请人： Chen Juyu ,  Chen Yan ,  Zhang Huiwen ,  Wang Xiaogang ,  Xu Mingkai

发明人： Chen Juyu ,  Chen Yan ,  Zhang Huiwen ,  Wang Xiaogang ,  Xu Mingkai

IPC分类号： C12N15/74 ,  C12N1/21

CPC分类号： C12N15/74 ,  C07K14/31

摘要： The present invention relates to an α-hemolysin-deletion mutant of SEs-producing Staphylococcus aureus and a construction method thereof. Said mutant is a genetically engineered strain obtained by deleting an α-hemolysin (α-HL) gene of a wild type Staphylococcus aureus strain by a homologous recombination method. The genetically engineered strain has the same genetic background as the wild strain except no α-hemolysin is produced.

摘要翻译： 本发明涉及产生SE的金黄色葡萄球菌的α-溶血素缺失突变体及其构建方法。 所述突变体是通过同源重组方法缺失野生型金黄色葡萄球菌菌株的α-溶血素（α-HL）基因而获得的遗传工程菌株。 遗传工程菌株具有与野生菌株相同的遗传背景，除了不产生α-溶血素。

公开(公告)号：US20060259354A1

公开(公告)日：2006-11-16

申请号：US11431596

申请日：2006-05-11

申请人： Chen Yan

发明人： Chen Yan

IPC分类号： G07B15/00 ,  G07B15/02

CPC分类号： G07F17/0014 ,  G06Q20/127 ,  G06Q20/14 ,  G06Q20/16 ,  G07B15/02 ,  G07B15/04 ,  G07B15/063

摘要： A billing management system of parking facility mainly comprises: The vehicle enters the parking facility and initiates LOOP sensor to start up the voice operation instruction; The vehicle owner inputs the number of his cellular phone and selects the charging method for opening the gate bar to drive it into the parking facility for parking; When picking the vehicle to leave, the vehicle owner re-input the same cellular phone number as that during entering the parking facility so as to let the management system display or voice inform parking duration and the amount of the parking fee obligated; Next, the vehicle owner selects to pay the parking fee by cash payment on-site or by the telephone bill of his cellular phone to complete the parking fee payment so as to let the system print out the invoice or receipt; Then, the exit gate bar will open to let the vehicle owner drive his vehicle out of the parking facility. That effectively eliminates the printing and losing possibility of the park ticket or picking voucher and achieve the safe control effect in preventing the parking vehicle from stealing Meanwhile, it provides the vehicle owner the convenience in combination of cellular phone number as input method as well as promotes the manual management and running efficiency of the parking facility.

摘要翻译： 停车设施的计费管理系统主要包括：车辆进入停车场，启动LOOP传感器启动语音操作指令; 车主输入他的手机号码，并选择打开门栏的充电方式将其推入停车设施进行停车; 当车辆离开时，车主重新输入与进入停车设施时相同的蜂窝电话号码，以使管理系统显示或声音通知停车时间和停车费的金额; 接下来，车主选择通过现场现金支付停车费或通过手机电话费来支付停车费，以完成停车费的付款，以便系统打印出发票或收据; 然后，出口门栏将打开，让车主将车辆从停车设施中驶出。 有效地消除了公园机票或采摘凭证的打印和丢失的可能性，并且实现了防止停车的窃取的安全控制效果。同时，它为车主提供便携式电话号码作为输入方法的组合以及促进 停车设施的手动管理和运行效率。

公开(公告)号：US07057390B1

公开(公告)日：2006-06-06

申请号：US10945408

申请日：2004-09-20

申请人： Nikolai I. Sinkine ,  Chen Yan ,  Cornelis Apeldoorn ,  Jeffrey Glenn Dail ,  Randolph Frank Wojcik ,  William Gunning

发明人： Nikolai I. Sinkine ,  Chen Yan ,  Cornelis Apeldoorn ,  Jeffrey Glenn Dail ,  Randolph Frank Wojcik ,  William Gunning

IPC分类号： G01V3/00 ,  H05B37/02

CPC分类号： H05H7/04

摘要： An improved raster magnet driver for a linear particle beam is based on an H-bridge technique. Four branches of power HEXFETs form a two-by-two switch. Switching the HEXFETs in a predetermined order and at the right frequency produces a triangular current waveform. An H-bridge controller controls switching sequence and timing. The magnetic field of the coil follows the shape of the waveform and thus steers the beam using a triangular rather than a sinusoidal waveform. The system produces a raster pattern having a highly uniform raster density distribution, eliminates target heating from non-uniform raster density distributions, and produces higher levels of beam current.

摘要翻译： 用于线性粒子束的改进的光栅磁体驱动器基于H桥技术。 电源HEXFET的四个分支形成一个两乘二开关。 以预定顺序和正确的频率切换HEXFET产生三角形电流波形。 H桥控制器控制切换顺序和时序。 线圈的磁场遵循波形的形状，因此使用三角波而不是正弦波形来引导光束。 该系统产生具有高均匀光栅密度分布的光栅图案，消除了来自不均匀光栅密度分布的目标加热，并产生更高水平的束流。

公开(公告)号：US06380545B1

公开(公告)日：2002-04-30

申请号：US09385803

申请日：1999-08-30

申请人： Chen Yan

发明人： Chen Yan

IPC分类号： H01J37141

CPC分类号： H01J37/147

摘要： A conventional particle generation and magnet configuration are used in combination with a relatively low-power power amplifier, a resonant loop magnet driver system, an amplitude modulator that induces a homogeneous amplitude function proportional to (t)½ and, when individual X and Y magnets are used, a precision phase shifter that induces a 90° phase shift in the applied power to one of the magnets to produce a circular raster pattern of virtually uniform density.

摘要翻译： 传统的粒子产生和磁体配置与相对较低功率的功率放大器，谐振环路磁体驱动器系统，振幅调制器结合使用，该振幅调制器引起与（t）1/2成比例的均匀幅度函数，并且当个体X和Y磁体 被使用的是精密移相器，其将所施加的功率中的90°相移诱导到一个磁体，以产生几乎均匀密度的圆形光栅图案。