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公开(公告)号:US20100221251A1
公开(公告)日:2010-09-02
申请号:US12722394
申请日:2010-03-11
申请人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
发明人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
IPC分类号: A61K39/395 , C07D487/04 , A61K31/551 , A61K31/566 , A61K31/675 , A61K31/7068 , A61K38/08 , A61K31/7048 , A61K31/704 , A61K38/12 , A61P35/00
CPC分类号: C07D471/06 , A61K31/138 , A61K31/337 , A61K31/4535 , A61K31/4745 , A61K31/513 , A61K31/5377 , A61K31/5517 , A61K31/664 , A61K31/675 , A61K31/683 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/08 , A61K38/12 , C07D455/00 , C07D487/06 , C07F9/65583 , C07F9/6561 , C07K2/00
摘要: The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.
摘要翻译: 本发明涉及吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物,以及这些化合物的制备方法。 本发明还涉及包含吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法,通过向有需要的受试者施用治疗有效量的吡咯并喹啉基 - 吡咯-2,5-二酮化合物或吡咯并喹啉基 - 吡咯烷-2,5-二酮, 二酮化合物。
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公开(公告)号:US08377927B2
公开(公告)日:2013-02-19
申请号:US12722394
申请日:2010-03-11
申请人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
发明人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
IPC分类号: A61P35/00 , A61K31/55 , C07D243/00
CPC分类号: C07D471/06 , A61K31/138 , A61K31/337 , A61K31/4535 , A61K31/4745 , A61K31/513 , A61K31/5377 , A61K31/5517 , A61K31/664 , A61K31/675 , A61K31/683 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/08 , A61K38/12 , C07D455/00 , C07D487/06 , C07F9/65583 , C07F9/6561 , C07K2/00
摘要: The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.
摘要翻译: 本发明涉及吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物,以及这些化合物的制备方法。 本发明还涉及包含吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法,通过向有需要的受试者施用治疗有效量的吡咯并喹啉基 - 吡咯-2,5-二酮化合物或吡咯并喹啉基 - 吡咯烷-2,5-二酮, 二酮化合物。
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公开(公告)号:US07713969B2
公开(公告)日:2010-05-11
申请号:US11350335
申请日:2006-02-09
申请人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
发明人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
IPC分类号: A61P35/00 , A61K31/473 , A61K31/551 , A61K31/661 , C07D471/06 , C07D487/06 , C07F9/12
CPC分类号: C07D471/06 , A61K31/138 , A61K31/337 , A61K31/4535 , A61K31/4745 , A61K31/513 , A61K31/5377 , A61K31/5517 , A61K31/664 , A61K31/675 , A61K31/683 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/08 , A61K38/12 , C07D455/00 , C07D487/06 , C07F9/65583 , C07F9/6561 , C07K2/00
摘要: The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.
摘要翻译: 本发明涉及吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物,以及这些化合物的制备方法。 本发明还涉及包含吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法,通过向有需要的受试者施用治疗有效量的吡咯并喹啉基 - 吡咯-2,5-二酮化合物或吡咯并喹啉基 - 吡咯烷-2,5-二酮, 二酮化合物。
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