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公开(公告)号：US10912862B2
公开(公告)日：2021-02-09
申请号：US14377128
申请日：2013-02-05
IPC分类号： A61L27/58 , A61L27/22 , A61L27/36 , B29C39/00 , A61L27/54 , A61L27/56 , A61L27/38 , B29L31/00
摘要： The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
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公开(公告)号：US20150086605A1
公开(公告)日：2015-03-26
申请号：US14377128
申请日：2013-02-05
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/22 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/43 , A61L2300/608 , A61L2430/22 , B29C39/003 , B29L2031/7532 , B29L2031/755
摘要： The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
摘要翻译： 本文描述的技术涉及包含至少第一多孔生物材料层和第二不可渗透生物材料层的组合物以及与其相关的方法。 在一些实施方案中，本文所述的组合物和方法涉及伤口愈合，例如。 修复伤口和/或组织缺陷。
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公开(公告)号：US20210178017A1
公开(公告)日：2021-06-17
申请号：US17169195
申请日：2021-02-05
摘要： The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
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公开(公告)号：US20200165306A1
公开(公告)日：2020-05-28
申请号：US16534780
申请日：2019-08-07
申请人： Tufts University
IPC分类号： C07K14/435 , B23K26/402 , A61L27/56 , A61L27/22 , A61L27/52 , B23K26/361 , C12N5/00 , A61L27/38
摘要： The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
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公开(公告)号：US20190177560A1
公开(公告)日：2019-06-13
申请号：US16029316
申请日：2018-07-06
申请人： Tufts University
IPC分类号： C09D11/30 , G01N33/543 , C08K5/1535 , A61K47/42 , A61K33/24 , C09D11/04 , C09D11/38 , A61K41/00
摘要： The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
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公开(公告)号：US20180050109A1
公开(公告)日：2018-02-22
申请号：US15555225
申请日：2016-03-11
申请人： Tufts University
CPC分类号： A61K47/42 , A61K47/26 , C07K14/43518 , C07K14/43586 , D01F4/02
摘要： The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
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7.发明申请公开(公告)号：US20140370094A1
公开(公告)日：2014-12-18
申请号：US14356958
申请日：2012-11-08
申请人： Tufts University
CPC分类号： A61K9/70 , A61K35/28 , A61K35/44 , A61K38/1866 , A61K47/46 , A61L27/36 , A61L27/3687 , A61L27/3691 , A61L27/3886 , A61L27/507 , A61L27/54 , A61L2300/414 , A61L27/227 , C08L89/00
摘要： The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents.
摘要翻译： 本文提供的发明涉及基于丝的支架及其制造方法，其可用于一系列组织工程应用。 本文所述的制造方法提供了一种通用的平台，以通过具有可调整的整体性质（例如但不限于孔隙率，机械性，降解速率）的三维丝基支架来结合中空导管（例如，用于营养/氧输送） 并允许内皮化和/或细胞分隔，用于工程化各种复杂的组织等同物。
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公开(公告)号：US10731046B2
公开(公告)日：2020-08-04
申请号：US16029316
申请日：2018-07-06
申请人： Tufts University
IPC分类号： C09D11/30 , C09D11/04 , C09D11/38 , A61K47/42 , B41J2/01 , B41J2/04 , B41J2/135 , A61K33/24 , A61K41/00 , C08K5/1535 , G01N33/543
摘要： The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
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9.发明授权公开(公告)号：US10280204B2
公开(公告)日：2019-05-07
申请号：US15046903
申请日：2016-02-18
申请人： TUFTS UNIVERSITY
IPC分类号： C07K14/435 , D01F4/02 , B29C39/02 , B29D11/00 , G01N33/543 , G02B1/04 , G02B6/138 , G02B1/06 , G01N33/544 , B82Y20/00 , G02B6/12 , G02B1/00 , G02B5/18
摘要： A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
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公开(公告)号：US09802374B2
公开(公告)日：2017-10-31
申请号：US13963952
申请日：2013-08-09
申请人： Tufts University
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
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