公开(公告)号：US08249814B2

公开(公告)日：2012-08-21

申请号：US12091049

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G01N33/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： Disclosed is a method of testing for colorectal cancer in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has colorectal cancer. Also disclosed are kits for measuring data corresponding to the products of selected biomarkers, and kits and methods of monitoring therapeutic efficacy of treatments for colorectal cancer.

摘要翻译： 公开了一种通过提供对应于所选生物标志物的产物水平的数据并将数据应用于配方以提供测试个体是否具有结肠直肠癌的指示来测试测试个体中的结肠直肠癌的方法。 还公开了用于测量与所选生物标志物的产物相对应的数据的试剂盒，以及用于监测治疗结直肠癌的治疗功效的试剂盒和方法。

公开(公告)号：US20070213939A1

公开(公告)日：2007-09-13

申请号：US11585666

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20090208942A1

公开(公告)日：2009-08-20

申请号：US12091049

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： C12Q1/68 ,  G06G7/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标记物的一个或多个结直肠病理学或一种或多种结直肠病理学（在一个实施方案中为结肠直肠癌）亚型的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US08239136B2

公开(公告)日：2012-08-07

申请号：US11585666

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G01N33/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标记物的一个或多个结直肠病理学或一种或多种结直肠病理学（在一个实施方案中为结肠直肠癌）亚型的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20130013214A1

公开(公告)日：2013-01-10

申请号：US13566394

申请日：2012-08-03

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G06F19/24 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B5/00 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20060263797A1

公开(公告)日：2006-11-23

申请号：US11347944

申请日：2006-02-06

申请人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

发明人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

IPC分类号： C12Q1/68 ,  G01N33/567 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/102

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.

摘要翻译： 本发明涉及新生物标志物的鉴定和选择以及与没有骨关节炎的个体相比，在具有轻度骨关节炎的个体中差异表达的新型生物标志物组合的鉴定和选择。 与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断轻度骨关节炎的所述多核苷酸和蛋白质的试剂盒。 本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。 本发明还提供了使用本发明的生物标志物的产物鉴定骨关节炎的新型治疗靶标的方法。

公开(公告)号：US08483968B2

公开(公告)日：2013-07-09

申请号：US12777140

申请日：2010-05-10

申请人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

发明人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

IPC分类号： G01N33/48

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/102

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.

摘要翻译： 本发明涉及新生物标志物的鉴定和选择以及与没有骨关节炎的个体相比，在具有轻度骨关节炎的个体中差异表达的新型生物标志物组合的鉴定和选择。 与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断轻度骨关节炎的所述多核苷酸和蛋白质的试剂盒。 本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。 本发明还提供了使用本发明的生物标志物的产物鉴定骨关节炎的新型治疗靶标的方法。

公开(公告)号：US08142998B2

公开(公告)日：2012-03-27

申请号：US12554141

申请日：2009-09-04

申请人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao ,  Hongwei Zhang ,  Wayne Marshall

发明人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao ,  Hongwei Zhang ,  Wayne Marshall

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/36

CPC分类号： G01N33/564 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/15 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/105 ,  G01N2800/52

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing the polynucleotides and proteins and the use of the polynucleotides and proteins. The biomarker products can be used to identify therapeutic targets for osteoarthritis, and compounds that bind and/or modulate gene activity.

摘要翻译： 本发明涉及新型生物标志物的鉴定和选择以及在骨关节炎和/或在骨关节炎的特定阶段中差异表达的新型生物标志物组合的鉴定和选择，以及选择新型生物标志物组合的方法。 测量生物标志物的产物和生物标志物的组合在以下一个或多个中表现出特别的优点：（a）诊断个体具有关节炎，（b）区分两个阶段的骨关节炎（OA）和（c） 诊断个人具有特定的OA阶段。 与生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质在本发明的范围内，以及含有多核苷酸和蛋白质的试剂盒以及多核苷酸和蛋白质的用途。 生物标记产物可用于鉴定骨关节炎的治疗靶点，以及结合和/或调节基因活性的化合物。

公开(公告)号：US20100143916A1

公开(公告)日：2010-06-10

申请号：US12554141

申请日：2009-09-04

申请人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao ,  Hongwei Zhang ,  Wayne Marshall

发明人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao ,  Hongwei Zhang ,  Wayne Marshall

IPC分类号： C12Q1/68

CPC分类号： G01N33/564 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/15 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/105 ,  G01N2800/52

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). As would be understood, in order to measure the products of biomarkers of the invention, polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA). Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease progression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of compounds that bind and/or modulate the activity of the genes of the invention. The compounds identified via such methods are useful for the development of assays to study osteoarthritis and osteoarthritis progression. Further, the compounds identified via such methods are useful as lead compounds in the development of prophylactic and therapeutic compositions for the prevention, treatment, management and/or amelioration of osteoarthritis or a symptom thereof.

公开(公告)号：US07713695B2

公开(公告)日：2010-05-11

申请号：US11347944

申请日：2006-02-06

申请人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

发明人： Choong-Chin Liew ,  Hongwei Zhang ,  Adam Dempsey ,  Thomas Yager ,  Samuel Chao

IPC分类号： C12Q1/66 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/102

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.

摘要翻译： 本发明涉及新生物标志物的鉴定和选择以及与没有骨关节炎的个体相比，在具有轻度骨关节炎的个体中差异表达的新型生物标志物组合的鉴定和选择。 与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断轻度骨关节炎的所述多核苷酸和蛋白质的试剂盒。 本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。 本发明还提供了使用本发明的生物标志物的产物鉴定骨关节炎的新型治疗靶标的方法。