公开(公告)号：US20070134681A1

公开(公告)日：2007-06-14

申请号：US11417354

申请日：2006-05-02

申请人： Choong-Chin Liew ,  Mark Han ,  Tom Yager ,  Samuel Chao ,  Run Zheng

发明人： Choong-Chin Liew ,  Mark Han ,  Tom Yager ,  Samuel Chao ,  Run Zheng

IPC分类号： C12Q1/68

CPC分类号： G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with bladder cancer as compared with individuals without bladder cancer. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing bladder cancer. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for bladder cancer.

摘要翻译： 本发明涉及鉴定和选择新型生物标志物，并鉴定和选择与膀胱癌患者相比差异表达的新型生物标志物组合。 与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质也包括在本发明的范围内，如含有用于诊断膀胱癌的所述多核苷酸和蛋白质的试剂盒。 本发明进一步包括使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质，以监测个体的疾病回归并监测治疗方案的功效。 本发明还提供了使用本发明的生物标志物的产物鉴定膀胱癌的新型治疗靶标的方法。

公开(公告)号：US08249814B2

公开(公告)日：2012-08-21

申请号：US12091049

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G01N33/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： Disclosed is a method of testing for colorectal cancer in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has colorectal cancer. Also disclosed are kits for measuring data corresponding to the products of selected biomarkers, and kits and methods of monitoring therapeutic efficacy of treatments for colorectal cancer.

摘要翻译： 公开了一种通过提供对应于所选生物标志物的产物水平的数据并将数据应用于配方以提供测试个体是否具有结肠直肠癌的指示来测试测试个体中的结肠直肠癌的方法。 还公开了用于测量与所选生物标志物的产物相对应的数据的试剂盒，以及用于监测治疗结直肠癌的治疗功效的试剂盒和方法。

公开(公告)号：US20070213939A1

公开(公告)日：2007-09-13

申请号：US11585666

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20090208942A1

公开(公告)日：2009-08-20

申请号：US12091049

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： C12Q1/68 ,  G06G7/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标记物的一个或多个结直肠病理学或一种或多种结直肠病理学（在一个实施方案中为结肠直肠癌）亚型的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US08239136B2

公开(公告)日：2012-08-07

申请号：US11585666

申请日：2006-10-23

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G01N33/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. In other aspects a computer system is configured with instructions that cause the processor to provide a user with the indication of whether the test individual has colorectal pathology. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标记物的一个或多个结直肠病理学或一种或多种结直肠病理学（在一个实施方案中为结肠直肠癌）亚型的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 在其他方面，计算机系统配置有指令，其使得处理器向用户提供测试个体是否具有结肠直肠病理学的指示。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20130013214A1

公开(公告)日：2013-01-10

申请号：US13566394

申请日：2012-08-03

申请人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

发明人： Choong-Chin Liew ,  Mark Han ,  Thomas Yager ,  Samuel Chao ,  Run Zheng ,  Hongwei Zhang

IPC分类号： G06F19/24 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B5/00 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  G16H50/30 ,  Y02A90/26

摘要： In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to a formula to provide an indication of whether the test individual has one or more colorectal pathologies or one or more subtypes of colorectal pathology. In some aspects the method is computer based and a computer applies the data to the formula. Also encompassed are kits for measuring data corresponding to the products of selected biomarkers which in some embodiments include a computer readable medium. Also encompassed are kits and methods of monitoring therapeutic efficacy of treatments for one or more colorectal pathologies.

摘要翻译： 在一个方面，本发明是通过提供对应于所选生物标志物的产物水平的数据并应用所述生物标志物的一个或多个结直肠病理学或一种或多种结直肠病理学亚型（在一个实施方案中为结肠直肠癌）的测试个体中的方法， 数据提供给公式，以提供测试个体是否具有一种或多种结肠直肠病变或一种或多种结直肠病理学亚型的指示。 在某些方面，该方法是基于计算机的，并且计算机将数据应用于公式。 还包括用于测量与所选生物标志物的产物相对应的数据的试剂盒，其在一些实施方案中包括计算机可读介质。 还包括监测一种或多种结肠直肠病变治疗效果的试剂盒和方法。

公开(公告)号：US20100099086A1

公开(公告)日：2010-04-22

申请号：US12384914

申请日：2009-04-10

申请人： Choong-Chin Liew ,  Samuel Chao

发明人： Choong-Chin Liew ,  Samuel Chao

IPC分类号： C12Q1/68 ,  C12N9/10 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  G06F17/10

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/166 ,  G01N33/57419 ,  G01N2800/50 ,  G01N2800/56 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

摘要： A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1: determining a level of RNA encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of RNA encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of RNA encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer.

摘要翻译： 公开了一种确定人类受试者具有结肠直肠癌而不是不具有结肠直肠癌的可能性的方法。 对于选自ANXA3，CLEC4D，IL2RB，LMNB1，PRRG4，TNFAIP6和VNN1的一组或多种基因的每个基因，该方法包括：测定受试对象的血液中基因编码的RNA水平 从而生成测试数据; 提供表示具有结肠直肠癌的人类对照受试者的血液中基因编码的RNA水平的阳性对照数据，并提供表示不具有结肠直肠癌的人类对照受试者的血液中由该基因编码的RNA水平的阴性对照数据; 并且确定测试数据对应于阳性对照数据而不是阴性对照数据的概率，其中测试数据对应于阳性对照数据而不是阴性对照数据的概率表示测试对象具有 结肠直肠癌相对于没有结肠直肠癌。

公开(公告)号：US08258284B2

公开(公告)日：2012-09-04

申请号：US12777042

申请日：2010-05-10

申请人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

发明人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

IPC分类号： C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens. The invention also provides for the identification of methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets of schizophrenia and/or bipolar disorder and a method of screening the genes of said biomarkers for additional markers of disease.

摘要翻译： 本发明涉及新型生物标志物的鉴定和选择以及在血液中差异表达并可用于诊断精神分裂症和/或双相性精神障碍以及监测治疗精神分裂症或双相性精神障碍的治疗功效的新型生物标志物组合的鉴定和选择。 本发明的生物标志物的产物和生物标志物的组合的表达水平的测量可用于诊断精神分裂症和/或双相性精神障碍。 使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质来测量本发明的生物标志物的产物的表达水平也包括在本发明的范围内，因为包含所述多核苷酸的组合物和试剂盒和 蛋白质。 本发明还包括使用多核苷酸和蛋白质来监测治疗方案的功效。 本发明还提供了鉴定使用本发明的生物标志物的产物在鉴定精神分裂症和/或双相性精神障碍的新型治疗靶标的方法，以及筛选所述生物标志物的基因以获得另外的疾病标志物的方法。

公开(公告)号：US20090098564A1

公开(公告)日：2009-04-16

申请号：US12287629

申请日：2008-10-10

申请人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

发明人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

摘要： The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens. The invention also provides for the identification of methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets of schizophrenia and/or bipolar disorder and a method of screening the genes of said biomarkers for additional markers of disease.

摘要翻译： 本发明涉及新型生物标志物的鉴定和选择以及在血液中差异表达并且可用于诊断精神分裂症和/或双相性精神障碍以及监测治疗精神分裂症或双相性精神障碍的治疗功效的新型生物标志物组合的鉴定和选择。 本发明的生物标志物的产物和生物标志物的组合的表达水平的测量可用于诊断精神分裂症和/或双相性精神障碍。 使用与本发明的生物标志物的产物特异性和/或选择性杂交的多核苷酸和蛋白质来测量本发明的生物标志物的产物的表达水平也包括在本发明的范围内，因为包含所述多核苷酸的组合物和试剂盒和 蛋白质。 本发明还包括使用多核苷酸和蛋白质来监测治疗方案的功效。 本发明还提供了鉴定使用本发明的生物标志物的产物在鉴定精神分裂症和/或双相性精神障碍的新型治疗靶标的方法，以及筛选所述生物标志物的基因以获得另外的疾病标志物的方法。

公开(公告)号：US20070269804A1

公开(公告)日：2007-11-22

申请号：US10568264

申请日：2005-06-20

申请人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

发明人： Choong-Chin Liew ,  Thomas Yager ,  Adam Dempsey ,  Samuel Chao

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： G06F19/24 ,  G06F19/18 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction of disease, stage of disease or disease risk; monitoring disease progression and/or regression; monitoring disease reoccurrence and identifying risk of disease reoccurrence; determining and/or predicting response to treatment and/or treatment outcomes; monitoring and/or predicting treatment compliance or non compliance and the like. The invention further provides a variety of selected molecular markers and a means to identify combinations of the selected molecular markers useful for diagnosing particular traits of interest.

摘要翻译： 本发明提供用于构建分类器的系统和方法，其使用来自血液样品的分子标记数据区分特征亚组。 本发明还包括在各种应用中使用分类器和由分类器鉴定的分子标记物的组合，包括：诊断; 预后; 疾病预测，疾病阶段或疾病风险; 监测疾病进展和/或消退; 监测疾病复发并发现疾病复发的风险; 确定和/或预测对治疗和/或治疗结果的反应; 监测和/或预测治疗依从性或不合规等。 本发明进一步提供了多种选择的分子标记和识别用于诊断感兴趣的特定性状的所选分子标记物的组合的方法。