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    ANTIBIOTIC SENSITIVE BACILLUS STRAINS HAVING ANTIMICROBIAL EFFECT AGAINST E. COLI AND CLOSTRIDIUM PERFRINGENS AND HAVING HIGH SPORULATION CAPACITY
    1.
    发明申请
    ANTIBIOTIC SENSITIVE BACILLUS STRAINS HAVING ANTIMICROBIAL EFFECT AGAINST E. COLI AND CLOSTRIDIUM PERFRINGENS AND HAVING HIGH SPORULATION CAPACITY 有权
    具有抗大肠杆菌和隐孢子虫的抗生素敏感菌株具有高运动能力的抗生素敏感菌株

    公开(公告)号：US20150079058A1

    公开(公告)日：2015-03-19

    申请号：US14391564

    申请日：2013-04-11

    Applicant: Chr. Hansen A/S

    Inventor： Beatrice Nielsen ,  Mette Dines Cantor ,  Birgitte Stuer-Lauridsen ,  Patrick Derkx ,  Eric Johansen

    IPC: A61K35/74 ,  A23K1/00

    CPC classification number: A61K35/742 ,  A23K10/18 ,  C12N1/20 ,  C12N15/01 ,  C12R1/07 ,  C12R1/125

    Abstract: A Bacillus strain characterized by (i): sensitivity for ampicillin, vancomycin, gentamicin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol; (ii) antimicrobial activity against E. coli and Clostridium perfringens; and (iii) a sporulation percentage of at least 80 when measured after 2 days of incubation. The invention further relates to a method for selecting such strains. Many of the identified strains according to the invention are of the species Bacillus amyloliquefaciens. Some of the Bacillus amyloliquefaciens were further identified as Bacillus amyloliquefaciens subsp. amyloliquefaciens whereas others were identified as amyloliquefaciens subsp. plantarum. A Bacillus strain of the invention may be used as a feed additive to animal feed where it has a probiotic effect.

    Abstract translation: 一种芽孢杆菌菌株，其特征在于：（i）：对氨苄青霉素，万古霉素，庆大霉素，卡那霉素，链霉素，红霉素，克林霉素，四环素和氯霉素的敏感性; （ii）对大肠杆菌和产气荚膜梭菌的抗菌活性; 和（iii）孵育2天后测量的至少80的孢子形成百分比。 本发明还涉及一种选择这种菌株的方法。 根据本发明的许多鉴定的菌株是物种解淀粉芽孢杆菌。 一些解淀粉芽孢杆菌进一步鉴定为解淀粉芽孢杆菌亚种。 解淀粉芽孢杆菌，而其他被鉴定为解淀粉芽孢杆菌亚种。 植物乳 本发明的芽孢杆菌菌株可以用作动物饲料的饲料添加剂，其具有益生菌作用。

    Method of producing Streptococcus thermophilus mutant strains
    4.
    发明授权
    Method of producing Streptococcus thermophilus mutant strains 有权

    公开(公告)号：US11564399B2

    公开(公告)日：2023-01-31

    申请号：US16615904

    申请日：2018-05-31

    Applicant: Chr. Hansen A/S

    Inventor： Jeorgos Trihaas ,  Thomas Janzen ,  Patrick Derkx

    IPC: A61K39/02 ,  A23C9/123 ,  C12N1/20 ,  C12N7/00 ,  C12N15/01 ,  C12R1/46

    Abstract: The present invention is directed to a method of producing a Streptococcus thermophilus strain comprising the steps of a) Providing a mother strain in the form of Streptococcus thermophilus DSM32502, b) Growing a culture of the mother strain in the presence of a bacteriophage, to which the mother strain is not resistant, to obtain a number of mutant strains, which are resistant to the said bacteriophage, c) Measuring the acidification time of the bacteriophage-resistant mutant strains and the mother strain in a milk base and selecting at least one mutant strain with a reduced acidification time as compared to the mother strain to obtain a fast-acidifying mutant strain.

    USE OF BACILLUS COMPOSITION FOR INCREASING THE AMOUNT OF AVAILABLE SUGARS IN ANIMAL FEED
    6.
    发明申请
    USE OF BACILLUS COMPOSITION FOR INCREASING THE AMOUNT OF AVAILABLE SUGARS IN ANIMAL FEED 有权
    用于增加动物饲料中可利用糖的量的微生物组合物的使用

    公开(公告)号：US20140349331A1

    公开(公告)日：2014-11-27

    申请号：US14248914

    申请日：2014-04-09

    Applicant: Chr. Hansen A/S

    Inventor： Beatrice Nielsen ,  Tina Styrishave ,  Mette Dines Cantor ,  Patrick Derkx ,  Jonna Nielsen ,  Robert Lantz

    IPC: C12Q1/02

    CPC classification number: C12Q1/02 ,  A23K10/18 ,  A23K20/163 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  G01N2333/32

    Abstract: Described are methods for assaying whether a Bacillus composition comprising at least one Bacillus strain is capable of increasing the amount of available sugar from animal feed comprising non-starch polysaccharides (NSP). Also described are methods for increasing the amount of available sugar from animal feed comprising non-starch polysaccharides (NSP), comprising adding to the animal feed a Bacillus composition comprising at least one Bacillus strain, which compositions produces 120 hexose equivalents (μmol/ml) or more when measured by the method described herein. Also described are animal feeds comprising 14% (w/w) or more of non-starch polysaccharides (NSP) if the animal feed is for a piglet, lactating sow, broiler or layer or 19% (w/w) or more of non-starch polysaccharides (NSP) if the animal feed is for a grower-finisher pig or gestating sow, and a Bacillus composition comprising at least one Bacillus strain, as well as methods and uses relating thereto.

    Abstract translation: 描述了用于测定包含至少一种芽孢杆菌菌株的芽孢杆菌组合物是否能够增加来自包含非淀粉多糖（NSP）的动物饲料的可用糖的量的方法。 还描述了用于增加来自包含非淀粉多糖（NSP）的动物饲料的可用糖的量的方法，其包括向动物饲料中加入包含至少一种芽孢杆菌菌株的芽孢杆菌组合物，该组合物产生120己糖当量（μmol/ ml） 或更多，当通过本文所述的方法测量时。 还描述了如果动物饲料用于仔猪，哺乳母猪，肉鸡或多层或19％（w / w）以上的非淀粉多糖（NSP），则含有14％（w / w） 淀粉多糖（NSP），如果动物饲料用于种植者育种猪或妊娠母猪，以及包含至少一种芽孢杆菌菌株的芽孢杆菌组合物，以及与其相关的方法和用途。

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