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公开(公告)号：US08582979B2
公开(公告)日：2013-11-12
申请号：US12193459
申请日：2008-08-18
CPC分类号： H04L27/04 , H04B10/505 , H04B10/5165 , H04B10/548 , H04L27/2601
摘要： From an real valued OFDM signal (S0(t)) is a baseband signal (SB(t)) derived and converted into a complex single sideband modulation signal (n(t)). This is modulated onto an optical carrier (fOC) to generate a SSB transmission signal (SOT) having a small bandwidth an carrying the information in the envelope or in the power of the envelope. According to the modulation direct detection is possible. Only a small bandwidth is necessary for the transmission.
摘要翻译： 从实值OFDM信号（S0（t））是基带信号（SB（t）），被导出并转换为复数单边带调制信号（n（t））。 这被调制到光载波（fOC）上以产生具有小带宽的SSB传输信号（SOT），其携带信封中的信息或信封的功率。 根据调制直接检测是可能的。 传输需要较小的带宽。
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公开(公告)号：US20090067833A1
公开(公告)日：2009-03-12
申请号：US12193459
申请日：2008-08-18
CPC分类号： H04L27/04 , H04B10/505 , H04B10/5165 , H04B10/548 , H04L27/2601
摘要： From an real valued OFDM signal (S0(t)) is a baseband signal (SB(t)) derived and converted into a complex single sideband modulation signal (n(t)). This is modulated onto an optical carrier (fOC) to generate a SSB transmission signal (SOT) having a small bandwidth an carrying the information in the envelope or in the power of the envelope. According to the modulation direct detection is possible. Only a small bandwidth is necessary for the transmission.
摘要翻译： 从实值OFDM信号（S0（t））是基带信号（SB（t）），被导出并转换为复数单边带调制信号（n（t））。 这被调制到光载波（fOC）上以产生具有小带宽的SSB传输信号（SOT），其携带信封中的信息或信封的功率。 根据调制直接检测是可能的。 传输需要较小的带宽。
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3.发明授权公开(公告)号：US08900829B2
公开(公告)日：2014-12-02
申请号：US13096932
申请日：2011-04-28
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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4.发明申请公开(公告)号：US20110244458A1
公开(公告)日：2011-10-06
申请号：US13096932
申请日：2011-04-28
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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5.发明申请公开(公告)号：US20110136115A1
公开(公告)日：2011-06-09
申请号：US12744318
申请日：2008-11-11
申请人： Andrew Z. Sledziewski , Shannon Payne , Matthias Schuster , Joern Lewin , Thomas Schlegel , Andrew M. Morotti
发明人： Andrew Z. Sledziewski , Shannon Payne , Matthias Schuster , Joern Lewin , Thomas Schlegel , Andrew M. Morotti
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测前列腺细胞增殖性疾病的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述病症的检测，从而能够改善患者的诊断和治疗。
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6.发明授权公开(公告)号：US07951563B2
公开(公告)日：2011-05-31
申请号：US11911617
申请日：2006-04-17
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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公开(公告)号：US20080286778A1
公开(公告)日：2008-11-20
申请号：US11885706
申请日：2006-03-02
申请人： Joern Lewin , Juergen Distler , Ralf Lesche , Matthias Schuster
发明人： Joern Lewin , Juergen Distler , Ralf Lesche , Matthias Schuster
CPC分类号： C12Q1/683 , C12Q1/6848 , C12Q1/6858 , C12Q2523/125 , C12Q2521/331
摘要： The invention relates to a method for sensitively and specifically detecting cytosine methylations. For this purpose, DNA is first analysed by reacting with the aid of a methylation specific restriction enzyme. In such a way, the background DNA is removed from a reaction preparation. At a next step, a specific conversion of a non-methylated cytosine is carried out, while a methylated cytosine remains unchanged. The converted DNA can be analysed according to different methods, in particular by means of real time PCR method.
摘要翻译： 本发明涉及敏感地和特异性检测胞嘧啶甲基化的方法。 为此，首先通过与甲基化特异性限制性内切酶的反应进行DNA分析。 以这种方式，从反应制备物中除去背景DNA。 在下一步骤中，进行非甲基化胞嘧啶的特异转化，而甲基化胞嘧啶保持不变。 可以根据不同的方法，特别是通过实时PCR方法分析转化的DNA。
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公开(公告)号：US09695478B2
公开(公告)日：2017-07-04
申请号：US12779856
申请日：2010-05-13
申请人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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公开(公告)号：US08646728B2
公开(公告)日：2014-02-11
申请号：US13325606
申请日：2011-12-14
申请人： Matthias Schuster
发明人： Matthias Schuster
IPC分类号： B64D1/12
摘要： A load lifting apparatus for a helicopter has a cable, including a supply length in a cable store. The cable is secured at one end to the helicopter and has a free end. A load-bearing element, on which a load to be raised can be secured, is arranged on the cable. The cable can be removed from the cable store in order to lower the load-bearing element downwards from the helicopter. As the load-bearing element is lowered or pulled upwards, the cable acts at a force-introduction location on the helicopter. The load-bearing element is arranged on the cable such that it can move along the cable. At least one cable-attachment location is present on the helicopter, and is spaced apart from the force-introduction location and has, or can have, the free end of the cable secured on it.
摘要翻译： 用于直升机的负载提升装置具有电缆，包括在电缆存储器中的供应长度。 电缆一端固定在直升机上，并具有自由端。 在该电缆上设置承载元件，在该载荷元件上可以固定待升起的载荷。 电缆可以从电缆仓中取出，以便从直升机向下降负载元件。 当承载元件下降或向上拉时，电缆作用在直升机上的力导入位置。 承载元件设置在电缆上，使其能够沿着电缆移动。 在直升机上存在至少一个电缆连接位置，并且与力导入位置间隔开，并且具有或可以具有固定在其上的电缆的自由端。
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公开(公告)号：US20110059432A1
公开(公告)日：2011-03-10
申请号：US11910887
申请日：2006-04-17
申请人： Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
发明人： Matthias Ballhause , Kurt Berlin , Theo De Vos , Dimo Dietrich , Volker Liebenberg , Catherine Lofton-Day , Joe Lograsso , Jennifer Maas , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner
摘要： Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA.
摘要翻译： 本发明的方面涉及从远程样品提供DNA片段的组合物和方法。 在特定方面，提供了包含DNA的远程样品，从远程样品中分离DNA，并以允许甲基化和非甲基化胞嘧啶分化的方式处理分离的DNA。 另外，具体实施方案提供了用于从远程样品衍生的DNA的甲基化分析的组合物和方法。 其他方面提供了亚硫酸氢盐处理的DNA的全基因组扩增的组合物和方法。
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