利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.036 秒)

    Cell penetrating peptides for intracellular delivery of molecules
    3.
    发明授权
    Cell penetrating peptides for intracellular delivery of molecules 有权
    细胞穿透肽用于分子的细胞内递送

    公开(公告)号：US07579318B2

    公开(公告)日：2009-08-25

    申请号：US11294421

    申请日：2005-12-06

    申请人： Gilles Divita ,  Frédéric Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    发明人： Gilles Divita ,  Frédéric Heitz ,  Catherine May Morris ,  Gudrun Aldrian-Herrada

    IPC分类号： A61K38/00

    CPC分类号： C07K14/00

    摘要： The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

    摘要翻译： 本发明涉及包含由GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8（SEQ ID No：1）组成的氨基酸序列的细胞穿透肽，其中X1为A，L或G，X2为W或无，X3为R或K，X4为K， L或S，X 5为L或K，X 6为R或W，X 7为K或S，X 8为A，V或Q，X 9为W，F或Y.这些CPP可用作递送核酸 酸和/或蛋白质和/或肽在体外或体内。

    Methods and compositions for delivering siRNA into mammalian cells
    5.
    发明授权
    Methods and compositions for delivering siRNA into mammalian cells 有权
    将siRNA递送到哺乳动物细胞中的方法和组合物

    公开(公告)号：US08354387B2

    公开(公告)日：2013-01-15

    申请号：US12390913

    申请日：2009-02-23

    申请人： Gilles Divita ,  May Catherine Morris ,  Frédéric Heitz ,  Federica Simeoni

    发明人： Gilles Divita ,  May Catherine Morris ,  Frédéric Heitz ,  Federica Simeoni

    IPC分类号： C12N15/11

    CPC分类号： A61K47/64

    摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.

    摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。

    Peptide carrier for delivering siRNA into mammalian cells
    6.
    发明授权
    Peptide carrier for delivering siRNA into mammalian cells 有权
    用于将siRNA递送到哺乳动物细胞中的载体

    公开(公告)号：US07514530B2

    公开(公告)日：2009-04-07

    申请号：US10831342

    申请日：2004-04-26

    申请人： Gilles Divita ,  May Catherine Morris ,  Frédéric Heitz ,  Federica Simeoni

    发明人： Gilles Divita ,  May Catherine Morris ,  Frédéric Heitz ,  Federica Simeoni

    IPC分类号： C07K7/00 ,  C07H21/04 ,  A61K31/70

    CPC分类号： A61K47/64

    摘要： Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.

    摘要翻译： 包含SEQ ID NO：1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2的肽载体和合适的siRNA的复合物，其中R 1表示任何氨基酸残基，更优选K或S，R 2为空或表示以下基团之一：半胱胺，半胱氨酸，硫醇，酰胺， 线性或分枝的任选取代的C1-C6烷基，伯胺或仲胺，奥昔克酸衍生物，脂质，磷脂或胆固醇，并且选择所述siRNA使靶mRNA沉默。