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公开(公告)号:US07713966B2
公开(公告)日:2010-05-11
申请号:US11986626
申请日:2007-11-20
申请人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher, Jr. , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgürtel , Bert Nolte , Arthur Taveras
发明人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher, Jr. , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgürtel , Bert Nolte , Arthur Taveras
IPC分类号: A61K31/535 , C07D265/12 , C07D413/00 , A01N43/00 , A01N43/46 , A61K31/553 , A61K31/554 , A61K31/55 , A61K31/54 , C07D498/00 , C07D291/08 , C07D281/02 , C07D267/02 , C07D223/16 , C07D513/00
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有氮杂双环的药物,特别涉及氮杂双环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新的氮杂双环MMP-3,MMP-8和/或MMP-13抑制化合物,其相对于目前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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公开(公告)号:US20080261968A1
公开(公告)日:2008-10-23
申请号:US11986626
申请日:2007-11-20
申请人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
发明人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
IPC分类号: A61K31/5375 , C07D239/72 , A61K31/517 , A61K31/52 , C07D413/02 , A61P19/02 , A61K31/519 , C07D473/00 , C07D495/04
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有氮杂双环的药物,特别涉及氮杂双环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新的氮杂双环MMP-3,MMP-8和/或MMP-13抑制化合物,其相对于目前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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公开(公告)号:US20120015920A1
公开(公告)日:2012-01-19
申请号:US13163457
申请日:2011-06-17
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, JR. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, JR. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号: A61K31/56 , A61K31/519 , A61K31/538 , A61P29/00 , A61P19/02 , A61P35/00 , A61P9/10 , A61P11/00 , A61P25/00 , A61P27/02 , A61P31/04 , A61P7/02 , A61P25/16 , A61P25/28 , A61P31/18 , C12N9/99 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US08835441B2
公开(公告)日:2014-09-16
申请号:US13163457
申请日:2011-06-17
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及具有下式的含酰胺的杂双环化合物:其中R1,R2,D和Q如说明书中所定义。 更具体地说,本发明提供了一类新的含有杂双环化合物的酰胺,其表现出与目前已知的MMP-13和MMP-3抑制剂有关的效力。
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公开(公告)号:US20100249102A1
公开(公告)日:2010-09-30
申请号:US12755326
申请日:2010-04-06
申请人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, JR. , Irving Sucholeiki , Arthur Taveras
发明人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, JR. , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/519 , A61K31/55 , A61K31/538 , C07D495/14 , C07D495/04 , C07D495/22 , A61P9/10 , A61P19/02 , A61P29/00
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
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公开(公告)号:US07749996B2
公开(公告)日:2010-07-06
申请号:US11986603
申请日:2007-11-20
申请人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, Jr. , Irving Sucholeiki , Arthur Taveras
发明人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, Jr. , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/535 , C07D413/00
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有三氮杂环的药物,尤其涉及氮杂三环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新型的azatricyclic MMP-3,MMP-8和/或MMP-13抑制化合物,其与当前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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公开(公告)号:US07795245B2
公开(公告)日:2010-09-14
申请号:US12001043
申请日:2007-12-07
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号: A61K31/397 , A61K31/519 , A61K31/535 , A01N43/90 , C07D487/00 , C07D413/00
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及具有下式的含酰胺的杂双环金属蛋白酶抑制剂化合物:其中R1,R2,R3和R4如说明书中所定义。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其含有杂双环化合物的酰胺,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20080161300A1
公开(公告)日:2008-07-03
申请号:US12001041
申请日:2007-12-07
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/536 , A61K31/519 , C07D265/36 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20070155738A1
公开(公告)日:2007-07-05
申请号:US11602140
申请日:2006-11-20
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/538 , A61K31/5377 , A61K31/519 , C07D491/04 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20100087420A1
公开(公告)日:2010-04-08
申请号:US12631360
申请日:2009-12-04
申请人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, JR. , Irving Sucholeiki , Arthur G. Taveras
发明人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgürtel , Hongbo Deng , Brian M. Gallagher, JR. , Irving Sucholeiki , Arthur G. Taveras
IPC分类号: A61K31/553 , C07D495/04 , C07D495/14 , C07D495/22 , A61K31/55 , A61K31/5377 , A61K31/519
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有三氮杂环的药物,尤其涉及氮杂三环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新型的azatricyclic MMP-3,MMP-8和/或MMP-13抑制化合物,其与当前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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