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1.发明申请公开(公告)号：US20080221111A1
公开(公告)日：2008-09-11
申请号：US11919742
申请日：2006-05-08
IPC分类号： A61K31/4985 , A61K31/44 , A61P11/00 , A61P21/00
CPC分类号： A61K31/41 , A61K31/505 , A61K2300/00
摘要： The invention describes the use of a PDE4 inhibitor in combination with BH4 or a BH4 derivative for the prevention and/or treatment of respiratory diseases.
摘要翻译： 本发明描述了PDE4抑制剂与BH4或BH4衍生物联合用于预防和/或治疗呼吸系统疾病的用途。
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![3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives](/abs-image/US/2015/04/28/US09018175B2/abs.jpg.150x150.jpg)
2.发明授权3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives 有权3,4,4a，10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物公开(公告)号：US09018175B2
公开(公告)日：2015-04-28
申请号：US13515214
申请日：2010-12-15
申请人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号： A61K31/56 , A61K31/519 , A61K31/5585 , C07D495/04 , C07D519/00
CPC分类号： C07D519/00
摘要： The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译： 其中A，R1，R2，R3和R5具有如说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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![NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS](/abs-image/US/2014/04/24/US20140113877A1/abs.jpg.150x150.jpg)
3.发明申请NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS 审中-公开新的3,4,4A，10B-四氢-1H-苯并[4,3-C]异喹啉化合物公开(公告)号：US20140113877A1
公开(公告)日：2014-04-24
申请号：US14124446
申请日：2012-06-12
申请人： Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
发明人： Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
IPC分类号： C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D495/04
摘要： The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译： 其中A，X，R1，R2，R3和R7具有说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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![3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES](/abs-image/US/2012/11/15/US20120289474A1/abs.jpg.150x150.jpg)
4.发明申请3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES 有权3,4,4A，10B-TETRAHYDRO-1H-噻吩并[4,3-c]异喹啉衍生物公开(公告)号：US20120289474A1
公开(公告)日：2012-11-15
申请号：US13515214
申请日：2010-12-15
申请人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号： A61K31/519 , A61K31/56 , A61K31/5585 , A61K31/59 , A61K31/7048 , A61P9/12 , A61P31/00 , A61P7/02 , A61P7/10 , A61P11/00 , A61P11/06 , A61P11/08 , C07D495/04 , A61P37/06
CPC分类号： C07D519/00
摘要： The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译： 其中A，R1，R2，R3和R5具有如说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号：US08648100B2
公开(公告)日：2014-02-11
申请号：US11918397
申请日：2006-04-12
申请人： Rolf Beume , Armin Hatzelmann , Degenhard Marx , Christian Schudt , Hermann Tenor , Saadia Eddahibi , Serge Adnot
发明人： Rolf Beume , Armin Hatzelmann , Degenhard Marx , Christian Schudt , Hermann Tenor , Saadia Eddahibi , Serge Adnot
IPC分类号： A61K31/44 , C07D213/74
CPC分类号： A61K31/4412 , A61K31/44 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/53
摘要： The invention relates to the use of Roflumilast, Roflumilast N-Oxide or a pharmaceutically acceptable salt of either for the treatment of pulmonary hypertension. The invention additionally relates to the use of Roflumilast, Roflumilast N-oxide or a pharmaceutically acceptable salt of either in combination with a PDE5 inhibitor or a pharmaceutically acceptable salt thereof for the treatment of pulmonary hypertension.
摘要翻译： 本发明涉及罗氟司特，罗氟司特N-氧化物或其药学上可接受的盐用于治疗肺动脉高压的用途。 本发明还涉及Roflumilast，Roflumilast N-氧化物或其药学上可接受的盐与PDE5抑制剂或其药学上可接受的盐的组合用于治疗肺动脉高压的用途。
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公开(公告)号：US20090215836A1
公开(公告)日：2009-08-27
申请号：US11918397
申请日：2006-04-12
申请人： Rolf Beume , Armin Hatzelmann , Degenhard Marx , Christian Schudt , Hermann Tenor , Saadia Eddahibi , Serge Adnot
发明人： Rolf Beume , Armin Hatzelmann , Degenhard Marx , Christian Schudt , Hermann Tenor , Saadia Eddahibi , Serge Adnot
CPC分类号： A61K31/4412 , A61K31/44 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/53
摘要： The invention relates to the use of Roflumilast, Roflumilast N-Oxide or a pharmaceutically acceptable salt of either for the treatment of pulmonary hypertension. The invention additionally relates to the use of Roflumilast, Roflumilast N-oxide or a pharmaceutically acceptable salt of either in combination with a PDE5 inhibitor or a pharmaceutically acceptable salt thereof for the treatment of pulmonary hypertension.
摘要翻译： 本发明涉及罗氟司特，罗氟司特N-氧化物或其药学上可接受的盐用于治疗肺动脉高压的用途。 本发明还涉及Roflumilast，Roflumilast N-氧化物或其药学上可接受的盐与PDE5抑制剂或其药学上可接受的盐的组合用于治疗肺动脉高压的用途。
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公开(公告)号：US20110218201A1
公开(公告)日：2011-09-08
申请号：US13128051
申请日：2009-11-12
申请人： Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人： Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号： A61K31/454 , C07D401/04 , C07D405/14 , A61K31/4709 , C07D401/14 , A61K31/4545 , C07D471/04 , A61K31/498 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P11/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译： 式（I）的化合物是4型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号：US08609848B2
公开(公告)日：2013-12-17
申请号：US13128051
申请日：2009-11-12
申请人： Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人： Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要： The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译： 式（I）的化合物是4型磷酸二酯酶的新型有效抑制剂。
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9.发明授权Use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis 有权使用环索奈德和抗组胺药联合用于治疗过敏性鼻炎公开(公告)号：US08486923B2
公开(公告)日：2013-07-16
申请号：US12973414
申请日：2010-12-20
申请人： Degenhard Marx , Helgart Müller
发明人： Degenhard Marx , Helgart Müller
CPC分类号： A61K45/06 , A61K9/0043 , A61K31/58 , A61K2300/00
摘要： The subject matter of this application relates to the combination of ciclesonide with an antihistamine.
摘要翻译： 本申请的主题涉及环索奈德与抗组胺药的组合。
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公开(公告)号：US20080214536A1
公开(公告)日：2008-09-04
申请号：US11885425
申请日：2006-03-09
申请人： Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Degenhard Marx , Hans-Peter Kley
发明人： Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Degenhard Marx , Hans-Peter Kley
IPC分类号： A61K31/473 , C07D221/12 , C07D401/02 , A61K31/5377 , A61P11/00 , A61K31/497 , C07D413/02
CPC分类号： C07D401/10 , C07D221/12
摘要： Compounds of a certain formula (I) in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 51，R 6和R 7具有说明书中所示含义的某种式（I）的化合物是新的有效的PDE4抑制剂。
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