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1.
公开(公告)号:US20110218201A1
公开(公告)日:2011-09-08
申请号:US13128051
申请日:2009-11-12
申请人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号: A61K31/454 , C07D401/04 , C07D405/14 , A61K31/4709 , C07D401/14 , A61K31/4545 , C07D471/04 , A61K31/498 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P11/00
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译: 式(I)的化合物是4型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US08609848B2
公开(公告)日:2013-12-17
申请号:US13128051
申请日:2009-11-12
申请人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
发明人: Imre Schlemminger , Beate Schmidt , Dieter Flockerzi , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Degenhard Marx , Clemens Braun , Raimund Külzer , Anke Heuser , Hans-Peter Kley , Geert Jan Sterk
IPC分类号: C07D401/00 , A61K31/445
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
摘要: The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.
摘要翻译: 式(I)的化合物是4型磷酸二酯酶的新型有效抑制剂。
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3.3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives 有权
标题翻译: 3,4,4a,10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物公开(公告)号:US09018175B2
公开(公告)日:2015-04-28
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/56 , A61K31/519 , A61K31/5585 , C07D495/04 , C07D519/00
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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4.3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES 有权
标题翻译: 3,4,4A,10B-TETRAHYDRO-1H-噻吩并[4,3-c]异喹啉衍生物公开(公告)号:US20120289474A1
公开(公告)日:2012-11-15
申请号:US13515214
申请日:2010-12-15
申请人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人: Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号: A61K31/519 , A61K31/56 , A61K31/5585 , A61K31/59 , A61K31/7048 , A61P9/12 , A61P31/00 , A61P7/02 , A61P7/10 , A61P11/00 , A61P11/06 , A61P11/08 , C07D495/04 , A61P37/06
CPC分类号: C07D519/00
摘要: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译: 其中A,R1,R2,R3和R5具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US20080119505A1
公开(公告)日:2008-05-22
申请号:US11795981
申请日:2006-01-31
申请人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley
发明人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley
IPC分类号: A61K31/4741 , A61K31/473 , C07D491/02 , C07D221/12
CPC分类号: C07D401/04
摘要: Compounds of a certain formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Har have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译: 其中R1,R2,R3,R31,R4,R5,R51和Har具有说明书中所示含义的某种式(I)的化合物是新的有效的PDE4抑制剂。
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公开(公告)号:US20080214536A1
公开(公告)日:2008-09-04
申请号:US11885425
申请日:2006-03-09
申请人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Degenhard Marx , Hans-Peter Kley
发明人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Johannes Barsig , Degenhard Marx , Hans-Peter Kley
IPC分类号: A61K31/473 , C07D221/12 , C07D401/02 , A61K31/5377 , A61P11/00 , A61K31/497 , C07D413/02
CPC分类号: C07D401/10 , C07D221/12
摘要: Compounds of a certain formula (I) in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译: 其中R 1,R 2,R 3,R 31,R 4,R 5,R 51,R 6和R 7具有说明书中所示含义的某种式(I)的化合物是新的有效的PDE4抑制剂。
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7.NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS 审中-公开
标题翻译: 新的3,4,4A,10B-四氢-1H-苯并[4,3-C]异喹啉化合物公开(公告)号:US20140113877A1
公开(公告)日:2014-04-24
申请号:US14124446
申请日:2012-06-12
申请人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
发明人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
IPC分类号: C07D519/00 , A61K45/06 , A61K31/519
CPC分类号: C07D519/00 , A61K31/519 , A61K45/06 , C07D495/04
摘要: The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译: 其中A,X,R1,R2,R3和R7具有说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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8.6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders 审中-公开
标题翻译: 6-杂芳基-1,2,3,4,4A,10B-六氢吡啶作为治疗炎性疾病的Pde4抑制剂公开(公告)号:US20080167316A1
公开(公告)日:2008-07-10
申请号:US11884935
申请日:2006-03-01
申请人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Adrea Wohlsen , Degenhard Marx , Hans-Peter Kley
发明人: Ulrich Kautz , Beate Schmidt , Dieter Flockerzi , Maria Vittoria Chiesa , Armin Hatzelmann , Christof Zitt , Adrea Wohlsen , Degenhard Marx , Hans-Peter Kley
IPC分类号: A61K31/473 , C07D221/12 , A61K31/501 , A61P43/00 , C07D401/02
CPC分类号: C07D401/04
摘要: Compounds of a certain formula I in which R1, R2, R3, R31, R4, R5, R51 and Har have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译: 其中R1,R2,R3,R31,R4,R5,R51和Har具有说明书中所示含义的某种式I的化合物是新的有效的PDE4抑制剂。
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公开(公告)号:US07838521B2
公开(公告)日:2010-11-23
申请号:US11661369
申请日:2005-09-05
申请人: Dieter Flockerzi , Ulrich Kautz , Armin Hatzelmann , Christof Zitt , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley , Jens Christoffers , Anna Rosiak
发明人: Dieter Flockerzi , Ulrich Kautz , Armin Hatzelmann , Christof Zitt , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley , Jens Christoffers , Anna Rosiak
IPC分类号: A61K31/535 , A61K31/497 , A61K31/44 , C07D413/00 , C07D401/00 , C07D491/00 , C07D315/00
CPC分类号: C07D491/04
摘要: The compounds of formula I in which R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
摘要翻译: 其中R1,R2和R3具有如说明书中给出的含义的式I化合物是新的有效的PDE4抑制剂。
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公开(公告)号:US20070259868A1
公开(公告)日:2007-11-08
申请号:US11661369
申请日:2005-09-05
申请人: Dieter Flockerzi , Ulrich Kautz , Armin Hatzelmann , Christof Zitt , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley , Jens Christoffers , Anna Rosiak
发明人: Dieter Flockerzi , Ulrich Kautz , Armin Hatzelmann , Christof Zitt , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley , Jens Christoffers , Anna Rosiak
IPC分类号: A61K31/436 , A61K31/496 , A61K31/5377 , A61P11/00 , A61P17/00 , C07D309/12 , C07D309/14 , C07D405/14 , C07D413/14 , C07D491/052
CPC分类号: C07D491/04
摘要: The compounds of formula I in which R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
摘要翻译: 其中R1,R2和R3具有如说明书中给出的含义的式I化合物是新的有效的PDE4抑制剂。
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