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31 条记录 (耗时 0.041 秒)

    Inhibitors of P2X3
    1.
    发明申请
    Inhibitors of P2X3 有权

    公开(公告)号：US20070037974A1

    公开(公告)日：2007-02-15

    申请号：US11502797

    申请日：2006-08-11

    申请人： Christine Brotherton-Pleiss ,  Michael Dillon ,  Shelley Gleason ,  Clara Jen Lin ,  Ryan Schoenfeld ,  Marzia Villa ,  Yansheng Zhai

    发明人： Christine Brotherton-Pleiss ,  Michael Dillon ,  Shelley Gleason ,  Clara Jen Lin ,  Ryan Schoenfeld ,  Marzia Villa ,  Yansheng Zhai

    IPC分类号： C07D413/14 ,  C07D403/14

    CPC分类号： C07D213/81 ,  C07D231/56 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

    摘要： Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genito-urinary, gastrointestinal, and respiratory disorders: wherein R1 is —C(═S)CH3, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, furyl, furylcarbonyl, acetyl, or carbamoyl; R2a and R2b are independently H, methyl, or ethyl; R3 is H or methyl; Y is a bond, —(CR4R5)n— or —CR4═CR5—; wherein R4 and R5 are each independently H or methyl and n is 1 or 2; X is N or CH; A is phenyl, 5-membered heterocyclyl, or 6-membered heterocyclyl; R6, R7 and R8 are each independently H, halo, lower alkyl, cycloalkyl, alkylthio, alkylthio-lower alkyl, alkylsulfonyl-lower alkyl, di(lower alkyl)amino-lower alkyl, morpholinyl-lower alkyl, 4-methyl-piperazinyl-methyl, trifluoromethyl, pyridyl, tetrazolyl, thiophenyl, phenyl, biphenyl, or benzyl (where thiophenyl, phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoromethyl, lower alkoxy or lower alkylthio) or R6 and R7 together form a 5-membered or 6-membered carbocyclic or heterocyclic ring substituted with 0-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, oxo, halo, thiophenyl-lower alkyl, phenyl, benzyl (where phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoro-methyl, lower alkoxy, lower alkylthio, amino-lower alkyl, lower alkylamino-lower alkyl, or di(lower alkyl)amino-lower alkyl); and pharmaceutically acceptable salts thereof; wherein when R1 is pyrimidin-2-yl, X is N, Y is a bond and A is oxazol-5-yl the carbon atom at position 4 in said oxazol-5-yl is not substituted by propyl when the carbon atom at position 2 in said oxazol-5-yl is substituted by substituted phenyl and the carbon atom at position 4 in said oxazol-5-yl is not substituted by phenyl when the carbon atom at position 2 is substituted by unsubstituted or substituted phenyl.

    System and method for managing entitlements to data over a network
    2.
    发明授权
    System and method for managing entitlements to data over a network 有权
    通过网络管理数据的权利的系统和方法

    公开(公告)号：US09258608B2

    公开(公告)日：2016-02-09

    申请号：US13721154

    申请日：2012-12-20

    申请人： Michael Dillon ,  Peter Stern ,  Jon Putsch ,  Matthew Meyers

    发明人： Michael Dillon ,  Peter Stern ,  Jon Putsch ,  Matthew Meyers

    IPC分类号： H04N21/45 ,  G06F21/10 ,  H04N7/167 ,  H04N21/254 ,  H04N21/266 ,  H04N21/6334 ,  H04N21/643 ,  H04N21/658

    CPC分类号： H04N21/2541 ,  G06F21/10 ,  H04N7/1675 ,  H04N21/26606 ,  H04N21/4108 ,  H04N21/4508 ,  H04N21/4623 ,  H04N21/4627 ,  H04N21/6334 ,  H04N21/64322 ,  H04N21/6581

    摘要： A system and method for determining entitlement to content residing on a server. A subscriber account with a multi-channel video program distributor (MVPD) includes subscription information indicative of the services provided by the MVPD to the subscriber. A computing device operated by the subscriber sends a request for access to content controlled by the MVPD. The request is received by the MVPD and forwarded to an entitlements server. The entitlement server sends an access granted message to the MVPD when the subscriber is entitled to receive the requested content. The IP address of the subscriber computing device is used to determine whether the computing device is connected to the network via a network access device authorized by the MVPD. The “on-net” or “off-net” status of the computing device may be used to determine whether the subscriber receives the requested content and/or a quality of service level applied to the content.

    摘要翻译： 用于确定驻留在服务器上的内容的授权的系统和方法。 具有多频道视频节目分配器（MVPD）的订户帐户包括指示由MVPD向用户提供的服务的订阅信息。 由用户操作的计算设备发送对由MVPD控制的内容的访问请求。 该请求由MVPD接收并转发给授权服务器。 当用户有权接收所请求的内容时，授权服务器向MVPD发送访问授权消息。 用户计算设备的IP地址用于确定计算设备是否经由MVPD授权的网络接入设备连接到网络。 可以使用计算设备的“网上”或“非网”状态来确定用户是否接收到所请求的内容和/或应用于内容的服务质量等级。

    System and method for affecting the behavior of a network device in a cable network
    3.
    发明授权
    System and method for affecting the behavior of a network device in a cable network 有权
    影响有线网络中网络设备行为的系统和方法

    公开(公告)号：US08239506B2

    公开(公告)日：2012-08-07

    申请号：US12424154

    申请日：2009-04-15

    申请人： Andrew Danforth ,  William Webb ,  Michael Dillon

    发明人： Andrew Danforth ,  William Webb ,  Michael Dillon

    IPC分类号： G06F15/177 ,  G06F17/00

    CPC分类号： H04L63/10 ,  H04L63/14

    摘要： A subscriber access control system (SACS) configures a network device connected to cable network to affect the behavior of that device. The SACS comprises a rules engine and a datastore that stores the current state of subscribers known to the SACS and historical request information. When the SACS receives a request to quarantine a device, it assigns attributes to a subscriber record accessed by a DHCP server to affect the configuration and behavior of that device. The actual behavior of the quarantined device is determined by the presence of the attribute and the value of the attribute.

    摘要翻译： 订户访问控制系统（SACS）配置连接到有线网络的网络设备以影响该设备的行为。 SACS包括规则引擎和数据存储，其存储SACS已知的当前状态和历史请求信息。 当SACS接收到隔离设备的请求时，它将向DHCP服务器访问的用户记录分配属性，以影响该设备的配置和行为。 隔离设备的实际行为由属性的存在和属性的值决定。

    Method and apparatus for use of hidden decoupling capacitors in an integrated circuit design
    4.
    发明申请
    Method and apparatus for use of hidden decoupling capacitors in an integrated circuit design 有权
    在集成电路设计中使用隐藏去耦电容器的方法和装置

    公开(公告)号：US20060075369A1

    公开(公告)日：2006-04-06

    申请号：US10952194

    申请日：2004-09-28

    申请人： Michael Dillon ,  Christopher Tremel

    发明人： Michael Dillon ,  Christopher Tremel

    IPC分类号： G06F17/50

    CPC分类号： G06F17/5072

    摘要： A method and apparatus are provided for placing cells in an integrated circuit layout pattern. A base layer layout pattern defines an array of base cell locations and base layer elements, wherein at least portions of some rows in the array are reserved for decoupling capacitor cells. Each decoupling capacitor cell has a width, which is greater than that of a single base cell location and which is abstracted from the base layer layout pattern. A cell library defines a plurality of cells, including a macro cell having open rows consistent with the rows in the base layer layout pattern that are reserved for the decoupling capacitor cells. The width of each decoupling capacitor cell is abstracted from the macro cell. Cells from the cell library, including the macro cell, are placed within a design layout pattern relative to the base layer layout pattern. An area consumed by the macro cell within the design layout pattern is independent of the width of the decoupling capacitor cells.

    摘要翻译： 提供了一种用于将电池放置在集成电路布局图案中的方法和装置。 基层布局图形定义基本单元位置和基层元素的阵列，其中阵列中的一些行的至少部分被保留用于去耦合电容器单元。 每个去耦电容器单元的宽度大于单个基本单元位置的宽度，并且从基层布局图案中抽取出来。 单元库定义多个单元，包括具有与为去耦电容器单元保留的基层布局图案中的行一致的开放行的宏单元。 每个去耦电容器单元的宽度从宏单元中抽象出来。 来自细胞库的细胞（包括宏细胞）相对于基底层布局图案被放置在设计布局图案内。 设计布局图案内宏单元消耗的面积与去耦电容单元的宽度无关。

    System and method for managing the delivery of targeted content
    6.
    发明授权
    System and method for managing the delivery of targeted content 有权
    用于管理目标内容的传送的系统和方法

    公开(公告)号：US08412814B2

    公开(公告)日：2013-04-02

    申请号：US12718346

    申请日：2010-03-05

    申请人： Howard Pfeffer ,  Peter Stern ,  Michael Dillon

    发明人： Howard Pfeffer ,  Peter Stern ,  Michael Dillon

    IPC分类号： G06F15/16 ,  G06F3/01 ,  G06Q30/02

    CPC分类号： H04L67/02 ,  G06F3/00 ,  G06F15/16 ,  G06F21/6263 ,  G06Q30/02 ,  G06Q30/0269 ,  G06Q30/0277 ,  H04L63/0421 ,  H04L67/04 ,  H04L67/22 ,  H04L67/306 ,  H04L69/22

    摘要： A system and method for managing the delivery of targeted content. When a user desires to opt-out of receiving targeted content, the user registers with a do-not-target (DNT) registry and is issued a DNT cookie. The DNT cookie is a domain cookie that is stored on a user network access device. A provider of targeted content may look for the DNT cookie stored on the user's network access device. When the DNT cookie is not found, then the provider may deliver targeted content to the user. When the DNT cookie is found, then the provider may not deliver targeted content to the user. A Web site may offer the user an “override” cookie that allows that Web site to provide targeted content, or selected targeted content, even when the user has a DNT cookie. Alternatively, a DNT header can be added to a Web page request that indicates that the user does not want to receive targeted content. The DNT header may be overridden by an override cookie.

    摘要翻译： 用于管理目标内容的传递的系统和方法。 当用户希望选择停止接收有针对性的内容时，用户向不注册目标（DNT）注册并注册了一个DNT cookie。 DNT cookie是存储在用户网络访问设备上的域cookie。 有针对性的内容提供商可以查找存储在用户的网络访问设备上的DNT cookie。 当没有找到DNT cookie时，提供商可以向用户传递有针对性的内容。 当找到DNT cookie时，提供商可能不会向用户提供有针对性的内容。 网站可以向用户提供覆盖cookie，即使在用户具有DNT cookie时也允许该网站提供有针对性的内容或选定的目标内容。 或者，可以将DNT头添加到指示用户不想接收目标内容的网页请求。 DNT标头可能会被覆盖Cookie覆盖。