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公开(公告)号：US20150126513A1
公开(公告)日：2015-05-07
申请号：US14154173
申请日：2012-07-13
申请人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucian V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucian V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
IPC分类号： C07D401/04 , C07D487/04 , C07D498/04 , C07D401/14 , C07D513/04 , C07D471/04 , C07D491/052 , C07D495/04
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R 1 -R 4和n如本文所定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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公开(公告)号：US09163003B2
公开(公告)日：2015-10-20
申请号：US14154173
申请日：2012-07-13
申请人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
IPC分类号： C07D491/052 , C07D493/04 , C07D401/12 , C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R 1 -R 4和n如本文所定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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3.发明授权公开(公告)号：US09181266B2
公开(公告)日：2015-11-10
申请号：US14154161
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser , Zhuoliang Chen
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser , Zhuoliang Chen
IPC分类号： C07D401/12 , C07D409/14 , A61K31/453 , A61K31/4545 , C07D491/052 , C07D493/04
CPC分类号： C07D491/052 , A61K31/453 , A61K31/4545 , C07D401/12 , C07D409/14 , C07D493/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R1-R5和L在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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4.发明申请NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS 有权新型2-哌啶-1-基乙酰胺化合物用作丹麦酯抑制剂公开(公告)号：US20150025070A1
公开(公告)日：2015-01-22
申请号：US14154161
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D. Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D. Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser
IPC分类号： C07D491/052 , C07D493/04 , C07D401/12
CPC分类号： C07D491/052 , A61K31/453 , A61K31/4545 , C07D401/12 , C07D409/14 , C07D493/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R1-R5和L在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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![4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors](/abs-image/US/2016/01/05/US09227982B2/abs.jpg.150x150.jpg)
5.发明授权4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors 有权用作阻聚酶抑制剂的4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-d]嘧啶基化合物公开(公告)号：US09227982B2
公开(公告)日：2016-01-05
申请号：US14154170
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D491/052
CPC分类号： C07D491/052 , A61K31/519
摘要： The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物，其中R 1和R 2在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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6.发明授权1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions 有权其中的1,4-二取代哒嗪类似物和用于治疗SMN缺陷相关病症的方法公开(公告)号：US08729263B2
公开(公告)日：2014-05-20
申请号：US13960917
申请日：2013-08-07
申请人： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
发明人： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC分类号： C07D401/00 , C07D237/30 , A01K31/00 , C07D243/08
CPC分类号： A61K31/501 , A61K31/41 , A61K31/427 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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