公开(公告)号：US09245657B2

公开(公告)日：2016-01-26

申请号：US14236453

申请日：2012-08-03

申请人： Nami Saito ,  Christoph Bert ,  Eike Rietzel

发明人： Nami Saito ,  Christoph Bert ,  Eike Rietzel

IPC分类号： A61N5/00 ,  G21K1/00 ,  A61N5/10 ,  G21K1/10

CPC分类号： G21K1/00 ,  A61N5/1043 ,  A61N5/1048 ,  A61N5/1075 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： The present disclosure relates to a particle energy modulating device for variably changing the energy of the particles of a particle beam. The particle energy modulating device has a variable energy varying device with a control value correcting device for correcting a supplied control value. The control value correcting device corrects the supplied control values through the use of previously determined calibration data.

摘要翻译： 本公开涉及用于可变地改变粒子束的粒子的能量的粒子能量调节装置。 粒子能量调节装置具有可变能量变化装置，其具有用于校正所提供的控制值的控制值校正装置。 控制值校正装置通过使用先前确定的校准数据来校正提供的控制值。

公开(公告)号：US20110297849A1

公开(公告)日：2011-12-08

申请号：US12996700

申请日：2009-06-08

申请人： Christoph Bert ,  Eike Rietzel

发明人： Christoph Bert ,  Eike Rietzel

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N5/1044 ,  A61N5/1065 ,  A61N2005/1087

摘要： The invention concerns a process for the deposition of an intended dose distribution in a cyclically moved target region moving cyclically (102) by means of multiple irradiations with a beam (105) approaching matrix points of a target matrix in at least two scannings, wherein in each of the scannings, matrix points are approached sequentially. It is characterized through the steps: establishing the maximal tolerance level for local deviation from the intended dose distribution, de-synchronizing the sequence of the irradiation and the cyclical motion of the target region (102), and partitioning the irradiation of the target region (102) in a sufficient number of scannings such that local deviations from the intended dose distribution correspond at most to the maximal tolerance level of deviation from the intended dose distribution. Furthermore, the invention also concerns an irradiation apparatus for executing a process of this type and a process for determining the control parameters for said irradiation apparatus.

摘要翻译： 本发明涉及一种用于在周期性移动的目标区域中循环移动的目标区域（102）中的预期剂量分布的沉积方法，该方法通过多次照射与在至少​​两次扫描中接近目标基质的矩阵点的束（105）沉积，其中在 每个扫描，矩阵点依次接近。 其目的是通过以下步骤来表征：建立与预期剂量分布的局部偏差的最大容差水平，使照射序列和目标区域（102）的循环运动解除同步，并且划分目标区域 102），使得与预期剂量分布的局部偏差最多对应于与预期剂量分布的偏差的最大容限水平的扫描量。 此外，本发明还涉及用于执行这种过程的照射装置和用于确定所述照射装置的控制参数的处理。

公开(公告)号：US20110309255A1

公开(公告)日：2011-12-22

申请号：US13056184

申请日：2009-07-30

申请人： Christoph Bert ,  Eike Rietzel ,  Wolfgang Enghardt ,  Katia Parodi

发明人： Christoph Bert ,  Eike Rietzel ,  Wolfgang Enghardt ,  Katia Parodi

IPC分类号： G01T1/164 ,  A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1067 ,  A61N2005/1052 ,  A61N2005/1087

摘要： The invention relates to an apparatus for evaluating an activity distribution obtained in a moved target object by a beam that is generated by an irradiation device. Said apparatus comprises: a positron emission tomograph designed to record photons generated in the target object by the beam and generate measurement data representing points of origin of the photons; a movement detection device designed to generate a movement signal representing the movement of the target object; and an evaluation unit designed to associate the points of origin of the measured photons with positions in the target object with the help of the movement signal such that three-dimensional characteristics of the activity distribution actually generated in the target object can be evaluated by means of the photons generated by the beam. The invention further relates to an irradiation system and a method in which such an apparatus is used.

摘要翻译： 本发明涉及一种用于通过由照射装置产生的光束来评估在移动的目标物体中获得的活动分布的装置。 所述装置包括：正电子发射断层摄影机，被设计成通过光束记录在目标物体中产生的光子，并生成表示光子原点的测量数据; 运动检测装置，被设计成产生表示目标物体的运动的运动信号; 以及评估单元，其被设计为借助移动信号将测量的光子的原点与目标对象中的位置相关联，使得可以通过以下方式来评估在目标对象中实际生成的活动分布的三维特征： 由光束产生的光子。 本发明还涉及一种使用这种装置的照射系统和方法。

公开(公告)号：US20110027853A1

公开(公告)日：2011-02-03

申请号：US12511715

申请日：2009-07-29

申请人： Christoph Bert ,  Eike Rietzel ,  Alexander Gemmel

发明人： Christoph Bert ,  Eike Rietzel ,  Alexander Gemmel

IPC分类号： C12N13/00 ,  C12M1/34

CPC分类号： A61N5/1048 ,  A61N2005/1072 ,  A61N2005/1076 ,  A61N2005/1087

摘要： A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.

摘要翻译： 考虑到有效生物剂量的运动影响下用于体外验证辐射程序的幻影装置包括具有第一生物检测器和第一生物样品的体模。 第一生物样品包括多个培养和照射元件。 每个培养和照射元件设置有相应的生物子样品，使得第一生物检测器被配置为空间分辨生物检测器。 第一运动装置被配置为移动第一生物检测器以便模拟目标体积的运动。

公开(公告)号：US20100108903A1

公开(公告)日：2010-05-06

申请号：US12532590

申请日：2008-02-19

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： H01J3/14 ,  A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1061 ,  A61N2005/1087

摘要： Abstract: A control parameter is determined for a system (10) for irradiating a predetermined target volume in a body (77) with a particle beam (75). The system is constructed to direct the particle beam at a multiplicity of target points (30) in the target volume in succession in order to produce at, each of the target points a predetermined dose distribution (42) in a region around the target point. The control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points. For determination of the control parameter, there is first determined (94) a movement parameter which quantitatively characterises the movement of the body at the first target point. The control parameter is determined (95) in dependence on the movement parameter.

摘要翻译： 摘要：确定用于用粒子束（75）照射体（77）中的预定目标体积的系统（10）的控制参数。 该系统构造成将粒子束连续地引导到目标体积中的多个目标点（30），以便在每个目标点处在目标点周围的区域中产生预定剂量分布（42）。 控制参数控制第一目标点的剂量分布与相邻目标点的剂量分布重叠的程度。 为了确定控制参数，首先确定（94）定量表征身体在第一目标点处的运动的运动参数。 控制参数根据移动参数确定（95）。

公开(公告)号：US20100074408A1

公开(公告)日：2010-03-25

申请号：US12532601

申请日：2008-03-19

申请人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

发明人： Christoph Bert ,  Gerhard Kraft ,  Eike Rietzel

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N2005/1087

摘要： A system for irradiating a predetermined target volume in a body with a particle beam is constructed to direct the particle beam at a multiplicity of target points in the body in succession, in order to produce at each of the target points a predetermined dose distribution. For the system there is determined a planning target volume by first determining, in a fictive homogeneous body, a target volume equivalent to the minimum target volume in the body. The equivalent target volume is extended by a safety margin, in order to determine the planning target volume.

摘要翻译： 构造用于以粒子束照射身体中的预定目标体积的系统，以将粒子束连续地引导到身体中的多个目标点，以便在每个目标点处产生预定的剂量分布。 对于系统，通过首先在虚构的均匀体中确定与体内最小目标体积相当的目标体积来确定计划目标体积。 为了确定计划目标量，相当的目标体积以安全余地进行扩展。

公开(公告)号：US20090095921A1

公开(公告)日：2009-04-16

申请号：US12086940

申请日：2006-12-08

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/00

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1043 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087 ,  G21K1/10

摘要： There is proposed a device for the slice-by-slice irradiation of tumour tissue (3) in a patient using a particle beam, having—an accelerator (7) for generating a particle beam (5) with predetermined energy for each slice, —a raster scanning device (9), acting on the particle beam (5), for the slice-by-slice scanning of the tumour tissue (3), —a modulator (17) for modulating the energy of the particle beam (5), —a detection device (37) for the time-resolved detection of the position of the tumour tissue (3) and having—a first storage device for storing data relating to the tumour tissue (3), which were determined prior to the irradiation operation, and for releasing that data to the raster scanning device (9) and to the modulator (17). The device is characterised by—a module (39), which registers the data on the course of the irradiation and the data of the detection device (37) which have been obtained during an irradiation operation.

摘要翻译： 提出了一种用于使用粒子束对患者的肿瘤组织（3）进行逐片照射的装置，该装置具有用于为每个切片生成具有预定能量的粒子束（5）的加速器（7） 作用于粒子束（5）的光栅扫描装置（9），用于肿瘤组织（3）的逐片扫描;调制器（17），用于调制粒子束（5）的能量; - 用于时间分辨检测肿瘤组织（3）的位置的检测装置（37），并具有用于存储与照射前相关的肿瘤组织（3）的数据的第一存储装置 操作，并将该数据释放到光栅扫描装置（9）和调制器（17）。 该装置的特征在于模块（39），其在辐射过程中登记数据和在照射操作期间获得的检测装置（37）的数据。

公开(公告)号：US09586058B2

公开(公告)日：2017-03-07

申请号：US13125888

申请日：2009-10-17

申请人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

发明人： Christoph Bert ,  Eike Rietzel ,  Gerhard Kraft

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1043 ,  A61N2005/1087

摘要： The idea concerns irradiation of a target volume (53), wherein intensities for target points (70) are determined which are sequentially approached by a beam, comprising the following steps: detecting a volume (63) to be protected, wherein a dose generated by irradiating a target volume (53) does not exceed a predetermined maximum value; determining intensities for target points (70) in such a way that within the volume (63) to be protected the generated dose does not exceed the predetermined maximum value, wherein a dose contribution data record is used for determining the intensities, which dose contribution data record comprises the dose generated at other spots (73) by directing the beam (10) on one of the target points (70) with a predetermined intensity.

摘要翻译： 该想法涉及目标体积（53）的照射，其中确定由光束顺序逼近的目标点（70）的强度，包括以下步骤：检测待保护的体积（63），其中由 照射目标体积（53）不超过预定的最大值; 以这样的方式确定目标点（70）的强度，使得在待保护的体积（63）内，所产生的剂量不超过预定的最大值，其中剂量贡献数据记录用于确定强度，哪个剂量贡献数据 记录包括通过以预定强度将光束（10）引导到其中一个目标点（70）上而在其它点（73）处产生的剂量。

公开(公告)号：US09044599B2

公开(公告)日：2015-06-02

申请号：US12996700

申请日：2009-06-08

申请人： Christoph Bert ,  Eike Rietzel

发明人： Christoph Bert ,  Eike Rietzel

IPC分类号： A61N5/01 ,  A61N5/10

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N5/1044 ,  A61N5/1065 ,  A61N2005/1087

摘要： The invention concerns a process for the deposition of an intended dose distribution in a cyclically moved target region moving cyclically (102) by means of multiple irradiations with a beam (105) approaching matrix points of a target matrix in at least two scannings, wherein in each of the scannings, matrix points are approached sequentially. It is characterized through the steps: establishing the maximal tolerance level for local deviation from the intended dose distribution, de-synchronizing the sequence of the irradiation and the cyclical motion of the target region (102), and partitioning the irradiation of the target region (102) in a sufficient number of scannings such that local deviations from the intended dose distribution correspond at most to the maximal tolerance level of deviation from the intended dose distribution. Furthermore, the invention also concerns an irradiation apparatus for executing a process of this type and a process for determining the control parameters for said irradiation apparatus.

摘要翻译： 本发明涉及一种用于在周期性移动的目标区域中循环移动的目标区域（102）中的预期剂量分布的沉积方法，该方法通过多次照射与在至少​​两次扫描中接近目标基质的矩阵点的束（105）沉积，其中在 每个扫描，矩阵点依次接近。 其目的是通过以下步骤来表征：建立与预期剂量分布的局部偏差的最大容差水平，使照射序列和目标区域（102）的循环运动解除同步，并且划分目标区域 102），使得与预期剂量分布的局部偏差最多对应于与预期剂量分布的偏差的最大容限水平的扫描量。 此外，本发明还涉及用于执行这种过程的照射装置和用于确定所述照射装置的控制参数的处理。

公开(公告)号：US20140166896A1

公开(公告)日：2014-06-19

申请号：US14112780

申请日：2012-04-20

申请人： Christoph Bert ,  Eike Rietzel

发明人： Christoph Bert ,  Eike Rietzel

IPC分类号： H01J37/304 ,  H01J37/317

CPC分类号： H01J37/304 ,  A61N5/1044 ,  A61N5/1067 ,  A61N2005/1087 ,  H01J37/317

摘要： To control of an irradiation installation, a particle beam is generated with a beam intensity, and a beam quality of the particle beam is monitored with a beam monitoring device. One of several adjustable measurement ranges is selected, wherein the measurement range of the beam monitoring device is set depending on the beam intensity of the particle beam and/or depending on a particle count to be applied.

摘要翻译： 为了控制照射装置，产生具有束强度的粒子束，并且用束监测装置监测粒子束的束质量。 选择多个可调测量范围中的一个，其中根据粒子束的束强度和/或取决于要施加的粒子数来设置光束监测装置的测量范围。