公开(公告)号：US4780401A

公开(公告)日：1988-10-25

申请号：US717738

申请日：1985-03-28

申请人： Christoph Heusser ,  Rudolf H. Andreatta ,  Sefik Alkan ,  Jeanette Wood

发明人： Christoph Heusser ,  Rudolf H. Andreatta ,  Sefik Alkan ,  Jeanette Wood

IPC分类号： G01N33/573 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P9/12 ,  C07K14/005 ,  C07K14/195 ,  C07K14/81 ,  C07K16/00 ,  C07K16/40 ,  C07K19/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  G01N33/53 ,  C12N15/00

CPC分类号： C07K16/40 ,  A61K38/00 ,  Y10S435/81 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/815 ,  Y10S530/808 ,  Y10S530/86

摘要： The invention relates to novel monoclonal antibodies having a high affinity for human renin, derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines that produce these antibodies, and to processes for the preparation of said hybridoma cells lines. The monoclonal antibodies according to the invention and their derivatives can be used for the qualitative and quantitative determination of human renin and structurally similar renin, for the purification of human renin and structurally similar renin and for the treatment of high blood pressure and cardiac insufficiency.

摘要翻译： 本发明涉及对人肾素高亲和力的新型单克隆抗体，其衍生物，制备这些抗体及其衍生物的方法，产生这些抗体的杂交瘤细胞系以及制备所述杂交瘤细胞系的方法。 根据本发明的单克隆抗体及其衍生物可用于人肾素和结构相似的肾素的定性和定量测定，用于纯化人肾素和结构相似的肾素，并用于治疗高血压和心脏功能不全。