公开(公告)号：US07368248B2

公开(公告)日：2008-05-06

申请号：US10415657

申请日：2001-11-09

申请人： Christophe Echeverri ,  Pierre Goenczy ,  Anthony Hyman ,  Steven Jones ,  Karen Oegema ,  Matthew Kirkham

发明人： Christophe Echeverri ,  Pierre Goenczy ,  Anthony Hyman ,  Steven Jones ,  Karen Oegema ,  Matthew Kirkham

IPC分类号： G01N33/53

CPC分类号： C07K14/43545 ,  A61K38/00

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell division and proliferation processes that could be identified by means of RNA-medicated interference (RNAi) and to the identification and isolation of functional orthologues of said genes including all biologically-active derivatives thereof. The invention further relates to the use of said gene products (including said orthologues) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂和增殖过程中的重要功能作用，可以通过RNA药物干扰（RNAi）和识别和分离功能性直向同源物 的所述基因，包括其所有生物活性衍生物。 本发明还涉及所述基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性疾病的诊断和治疗中的应用。

公开(公告)号：US20050101773A1

公开(公告)日：2005-05-12

申请号：US10415656

申请日：2001-11-09

申请人： Christophe Echeverri ,  Pierre Goenczy ,  Anthony Hyman ,  Steven Jones ,  Karen Oegema ,  Matthew Kirkham

发明人： Christophe Echeverri ,  Pierre Goenczy ,  Anthony Hyman ,  Steven Jones ,  Karen Oegema ,  Matthew Kirkham

IPC分类号： G01N33/50 ,  A61K31/7052 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P33/00 ,  C07K14/435 ,  C07K14/44 ,  C07K16/20 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/43545

摘要： The present invention relates to several C. elegans genes and gene products identified by means of RNA-mediated interference (RNAi) as required for the viability, growth or reproduction of nematodes and to functional orthologues of said genes and gene products found in other nematode species, including all biologically-active derivatives thereof. The invention also comprises the use of said genes and gene products in the development of anti-nematode or other pesticidal agents and in methods for diagnosis and treatment of diseases associated with the infection or presence of nematodes.

摘要翻译： 本发明涉及通过RNA介导的干扰（RNAi）鉴定的几种秀丽隐杆线虫基因和基因产物，其是线虫的活力，生长或繁殖以及所述基因的功能直向同源物以及在其它线虫种中发现的基因产物 ，包括其所有生物活性衍生物。 本发明还包括所述基因和基因产物在抗线虫或其它杀虫剂的开发中的用途以及用于诊断和治疗与感染或存在线虫有关的疾病的方法。

公开(公告)号：US20070042981A1

公开(公告)日：2007-02-22

申请号：US10572123

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： A61K48/00 ,  A61K39/395 ,  A61K38/55 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12N15/113 ,  A61K38/16 ,  A61K39/00 ,  A61K48/00 ,  C07K14/43545 ,  C07K14/43581 ,  C07K14/47 ,  C12N2799/021 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间染色质分离中的重要功能作用，可以通过RNA介导的干扰（RNAi）和识别和分离功能直系同源物 的所述基因包括其所有生物功能衍生物。 本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US20070093438A1

公开(公告)日：2007-04-26

申请号：US10572004

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： A61K48/00 ,  C40B40/08 ,  C40B30/06

CPC分类号： A01K67/0336 ,  A01K2217/058 ,  A01K2227/703 ,  A01K2267/0331 ,  C07K14/4738 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/12

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定 所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及 它们用于诊断和治疗增殖性和其他疾病。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US07648827B2

公开(公告)日：2010-01-19

申请号：US10572289

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gönczy ,  Birte Sönnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gönczy ,  Birte Sönnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： G01N33/574

CPC分类号： C12N15/113 ,  A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  C07K14/43545 ,  C07K14/43581 ,  C07K14/4738 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/6893 ,  G01N2500/00

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间细胞周期进程中的重要功能作用，可通过RNA介导的干扰（RNAi）鉴定和鉴定和分离功能 所述基因的直向同源物包括其所有生物功能衍生物。 本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US07479369B2

公开(公告)日：2009-01-20

申请号：US10572004

申请日：2004-09-15

申请人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gönczy ,  Birte Sönnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

发明人： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gönczy ,  Birte Sönnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： A01K67/0336 ,  A01K2217/058 ,  A01K2227/703 ,  A01K2267/0331 ,  C07K14/4738 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/12

摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

摘要翻译： 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定 所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及 它们用于诊断和治疗增殖性和其他疾病。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。