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公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。
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公开(公告)号：US06710172B1
公开(公告)日：2004-03-23
申请号：US09806769
申请日：2001-07-30
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
IPC分类号： C07H2104
CPC分类号： C07K14/4748
摘要： The present invention relates to nucleic acid molecules encoding antigenic peptides from MAGE molecules that bind to HLA. An example of the nucleic acid molecules of the present invention is a nucleic acid molecule coding for the peptide GVYDGREHTV (SEQ ID NO: 44), which peptide binds to HLA-A2. The nucleic acid molecules and the encoded antigenic peptides are useful for diagnosing and treating various pathological conditions.
摘要翻译： 本发明涉及编码结合HLA的MAGE分子的抗原肽的核酸分子。 本发明的核酸分子的实例是编码肽GVYDGREHTV（SEQ ID NO：44）的核酸分子，该肽与HLA-A2结合。 核酸分子和编码的抗原肽可用于诊断和治疗各种病理状况。
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公开(公告)号：US06531451B1
公开(公告)日：2003-03-11
申请号：US09289350
申请日：1999-04-09
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
IPC分类号： A61K3800
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：US06291430B1
公开(公告)日：2001-09-18
申请号：US09166448
申请日：1998-10-05
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： A61K3804
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US07252825B2
公开(公告)日：2007-08-07
申请号：US10170832
申请日：2002-06-12
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US06426217B1
公开(公告)日：2002-07-30
申请号：US09697884
申请日：2000-10-27
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： C12N100
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US06369211B1
公开(公告)日：2002-04-09
申请号：US09348933
申请日：1999-07-07
IPC分类号： C07H2102
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes the HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US5965535A
公开(公告)日：1999-10-12
申请号：US928615
申请日：1997-09-12
IPC分类号： C12N15/09 , A61K35/26 , A61K38/00 , A61K39/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/30 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/08 , A61K38/04 , A61K38/10
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes the HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4.sup.+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US07157091B1
公开(公告)日：2007-01-02
申请号：US09336091
申请日：1999-06-18
申请人： Jacques Van Snick , Bernard Lethé , Pascal Chaux , Thierry Boon-Falleur , Pierre van der Bruggen
发明人： Jacques Van Snick , Bernard Lethé , Pascal Chaux , Thierry Boon-Falleur , Pierre van der Bruggen
IPC分类号： C07K19/00 , C07K14/435 , C07K11/00 , A61K38/04 , A61K38/16
CPC分类号： C07K14/4748 , A61K38/00 , C07K2319/00 , Y10S514/885 , Y10S530/806 , Y10S530/828
摘要： The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid sequence set forth as SEQ ID NO:7, and an endosomal targeting signal comprising an endosomal targeting portion of human invariant chain Ii or LAMP-1.
摘要翻译： 本发明提供了分离的HLA DRB1 * 15结合肽，其由SEQ ID NO：7所示的氨基酸序列组成，在SEQ ID NO：7所示的氨基酸序列的任一端或两端加入0-10个氨基酸 ，以及包含人类不变链Ii或LAMP-1的内体靶向部分的内体靶向信号。
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公开(公告)号：US20090203124A1
公开(公告)日：2009-08-13
申请号：US12016690
申请日：2008-01-18
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of MAGE genes.
摘要翻译： 本发明描述了由MAGE肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE基因表达为特征的病症的方法和产品。
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