公开(公告)号：US08460227B2

公开(公告)日：2013-06-11

申请号：US12616081

申请日：2009-11-10

Applicant: Christopher Bare ,  David O. Shepard

Inventor： Christopher Bare ,  David O. Shepard

IPC: A61M37/00 ,  A61B19/00

CPC classification number: C07K14/54 ,  B01L3/5021

Abstract: Apparatus and methods for producing interleukin-1 receptor antagonist and/or other prophylatically or therapeutically effective protein. Blood is obtained from a patient with a conventional syringe and then introduced into dual luer lock centrifuge tube. The dual luer lock centrifuge tube is provided with beads that are coated with a silanized coating. The container is then incubated and centrifuged. Subsequent to the incubation and the centrifugation, the serum containing autologous therapeutically active protein, such as IL-1Ra, in the container is withdrawn through the luer lock of the container, and injected back into the patient.

Abstract translation: 用于产生白细胞介素-1受体拮抗剂和/或其它预防或治疗有效蛋白质的装置和方法。 使用常规注射器从患者获得血液，然后引入双路厄锁定离心管。 双路厄尔锁离心管配有涂有硅烷化涂层的珠子。 然后将容器温育并离心。 在孵育和离心之后，容器中含有自体治疗活性蛋白（例如IL-1Ra）的血清通过容器的鲁尔锁取出，并注射到患者体内。

公开(公告)号：US20100125236A1

公开(公告)日：2010-05-20

申请号：US12616081

申请日：2009-11-10

Applicant: Christopher Bare ,  David O. Shepard

Inventor： Christopher Bare ,  David O. Shepard

IPC: A61M1/36 ,  C12P1/00

CPC classification number: C07K14/54 ,  B01L3/5021

Abstract: Apparatus and methods for producing interleukin-1 receptor antagonist and/or other prophylatically or therapeutically effective protein. Blood is obtained from a patient with a conventional syringe and then introduced into dual luer lock centrifuge tube. The dual luer lock centrifuge tube is provided with beads that are coated with a silanized coating. The container is then incubated and centrifuged. Subsequent to the incubation and the centrifugation, the serum containing autologous therapeutically active protein, such as IL-1Ra, in the container is withdrawn through the luer lock of the container, and injected back into the patient.

Abstract translation: 用于产生白细胞介素-1受体拮抗剂和/或其它预防或治疗有效蛋白质的装置和方法。 使用常规注射器从患者获得血液，然后引入双路厄锁定离心管。 双路厄尔锁离心管配有涂有硅烷化涂层的珠子。 然后将容器温育并离心。 在孵育和离心之后，容器中含有自体治疗活性蛋白（例如IL-1Ra）的血清通过容器的鲁尔锁取出，并注射到患者体内。

公开(公告)号：US20120264699A1

公开(公告)日：2012-10-18

申请号：US13532178

申请日：2012-06-25

Applicant: Reinhold Schmieding ,  David O. Shepard

Inventor： Reinhold Schmieding ,  David O. Shepard

IPC: A61K38/02

CPC classification number: A61K35/16

Abstract: A method of producing blood serum containing prophylactically or therapeutically active proteins, including obtaining blood from a patient, incubating the blood at a suitable temperature to induce production of prophylactically or therapeutically active proteins, and removing the prophylactically or therapeutically active proteins from the blood.

Abstract translation: 一种产生含有预防或治疗活性蛋白质的血清的方法，包括从患者获得血液，在合适的温度下孵育血液以诱导产生预防或治疗活性蛋白质，以及从血液中除去预防或治疗活性蛋白质。

公开(公告)号：US08043315B2

公开(公告)日：2011-10-25

申请号：US10947217

申请日：2004-09-23

Applicant: David O. Shepard

Inventor： David O. Shepard

IPC: A61B17/32

CPC classification number: A61B17/1635 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1675 ,  A61B2017/00969 ,  A61B2090/062

Abstract: A method and apparatus for repairing isolated chondral defects using allograft implants. Lesions in articular tissue are corrected by forming a recipient socket in the tissue. A donor graft of a size corresponding to the recipient socket is harvested from a partial tissue specimen obtained from allograft material. The donor graft is implanted into the recipient socket.

Abstract translation: 使用同种异体移植物修复孤立软骨缺损的方法和装置。 通过在组织中形成受体插管来校正关节组织中的损伤。 从从同种异体移植物质获得的部分组织标本中收获与受体插座对应的尺寸的供体移植物。 供体移植物植入受体插座。

公开(公告)号：US07998206B2

公开(公告)日：2011-08-16

申请号：US11369962

申请日：2006-03-08

Applicant: David O. Shepard

Inventor： David O. Shepard

IPC: A61F2/28 ,  A61L2/00

CPC classification number: A61F2/30756 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30677 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61K35/32 ,  A61K38/00 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L2430/06

Abstract: An osteochondral centrifugation system for providing an osteochondral centrifuged core from a graft such as femoral condyle, for example. The centrifugation system may be used either in the operating room or, alternatively, at a tissue banking facility at the time of processing. The osteochondral centrifuged core is formed by (i) removing an osteochondral core from a graft; (ii) placing the osteochondral core in a centrifugation system to remove blood, lipids, or other potentially antigenic or contaminating materials, and to obtain a centrifuged core; and (iii) optionally, subjecting the centrifuged core to a material that reduces the chance of disease transmission and aids in the healing of the recipient site to which the centrifuged core is to be transferred.

Abstract translation: 用于从例如股骨髁的移植物提供骨软骨离心芯的骨软骨离心系统。 离心系统可以在手术室中使用，也可以在加工时用于组织银行设备。 骨软骨离心芯通过以下步骤形成：（i）从移植物中除去骨软骨; （ii）将骨软骨核心置于离心系统中以去除血液，脂质或其它潜在的抗原性或污染性物质，并获得离心芯; 和（iii）任选地，将离心的核心经受减少疾病传播机会的材料，并有助于离心核心转移到的受体部位的愈合。

公开(公告)号：US08465521B2

公开(公告)日：2013-06-18

申请号：US11546391

申请日：2006-10-12

Applicant: James L. Cook ,  David O. Shepard ,  Matthew C. Summitt

Inventor： James L. Cook ,  David O. Shepard ,  Matthew C. Summitt

IPC: A61B17/04 ,  A61B17/06

CPC classification number: A61B17/06 ,  A61B17/06166 ,  A61B2017/00867 ,  A61B2017/06057 ,  A61F2/0805

Abstract: A suture needle construct and method for extracapsular ligament reconstruction in mammals. The joint is first is first explored, and the damaged ligament and meniscus are debrided. The joint capsule is closed and a tunnel is created at the appropriate location in the proximal tibia for tibial fixation. Subsequent to the formation of the tibial tunnel, a suture having a substantially curved needle at one end and a substantially straight needle at the other end is brought in the proximity of the joint. The suture is passed around the lateral fabella using the substantially curved needle, then deep to the patellar ligament using the substantially straight needle, and through the tibial tunnel using the straight needle. The needles are cut off, and the sutures are tensioned over repair site.

Abstract translation: 哺乳动物外囊韧带重建的缝合针构造和方法。 首先探讨关节，解剖韧带和半月板损伤。 闭合关节囊，并在胫骨近端的适当位置产生隧道，用于胫骨固定。 在形成胫骨隧道之后，在一端具有基本上弯曲的针和在另一端具有基本上直的针的缝线被带到接头附近。 使用基本上弯曲的针将缝合线绕在外侧睑板上，然后使用基本上直的针深入髌韧带，并使用直针穿过胫骨隧道。 针头被切断，缝合线在修复部位张紧。

公开(公告)号：US20110118781A1

公开(公告)日：2011-05-19

申请号：US13012031

申请日：2011-01-24

Applicant: James L. Cook ,  David O. Shepard ,  Anthony Orozco

Inventor： James L. Cook ,  David O. Shepard ,  Anthony Orozco

IPC: A61B17/04

CPC classification number: A61D1/00 ,  A61B17/06066 ,  A61B17/1637 ,  A61B17/1675 ,  A61B2017/0404 ,  A61F2/0805 ,  A61F2/0811 ,  A61F2002/0882

Abstract: An apparatus and method for stabilization of a cranial cruciate ligament deficient stifle in canines using a suture-button construct. The method includes the steps of drilling a femoral hole across a distal femur, passing a needle with a pull-through suture strand of a suture-button construct through the femoral hole, and applying a tensile force to the pull-through suture strand and a suture tape or strand of the construct such that a first button of the suture-button construct lies sideways for passage through the femoral hole, advancing the first button through the femoral hole by pulling the pull-through suture strand until the first button exits the femoral hole, drilling a tibial hole and passing the needle with the pull-through suture strand through the tibial hole, applying a tensile force to the pull-through suture strand and the suture tape or strand of the construct such that the first button lies sideways for passage through the tibial hole, flipping the first button to engage the first button against the medial tibial cortex and subsequently cutting and removing the pull-through suture strand, pulling free ends of the suture tape or strand to advance a second button of the suture-button construct and to seat the second button against the femur, and securing the second button against the femur.

Abstract translation: 用于使用缝线按钮构造来稳定犬颅内十字韧带缺陷窒息的装置和方法。 该方法包括以下步骤：穿过股骨远端钻出股骨孔，使针穿过缝合线按钮构造的穿过缝合线通过股骨孔，并将拉力施加到穿过缝合线和 缝合带或线束，使得缝合线按钮构造的第一按钮侧向用于通过股骨孔，通过拉动穿通缝合线将第一按钮推进通过股孔，直到第一按钮离开股骨 穿过胫骨孔并穿过穿过缝合线的针穿过胫骨孔，向穿过缝合线和构造物的缝合带或股线施加张力，使得第一按钮位于侧面 通过胫骨孔，翻转第一按钮以将第一按钮接合到胫骨内侧皮质上，随后切割和移除穿过的缝合线，拉动fr 缝合带或股线的ee端部，以推进缝线按钮构造的第二按钮并将第二按钮抵靠股骨固定，并将第二按钮固定在股骨上。

公开(公告)号：US08202298B2

公开(公告)日：2012-06-19

申请号：US13012031

申请日：2011-01-24

Applicant: James L. Cook ,  David O. Shepard ,  Anthony Orozco

Inventor： James L. Cook ,  David O. Shepard ,  Anthony Orozco

IPC: A61B17/04 ,  A61B17/84 ,  A61F2/08

CPC classification number: A61D1/00 ,  A61B17/06066 ,  A61B17/1637 ,  A61B17/1675 ,  A61B2017/0404 ,  A61F2/0805 ,  A61F2/0811 ,  A61F2002/0882

Abstract: An apparatus and method for stabilization of a cranial cruciate ligament deficient stifle in canines using a suture-button construct. The method includes the steps of drilling a femoral hole across a distal femur, passing a needle with a pull-through suture strand of a suture-button construct through the femoral hole, and applying a tensile force to the pull-through suture strand and a suture tape or strand of the construct such that a first button of the suture-button construct lies sideways for passage through the femoral hole, advancing the first button through the femoral hole by pulling the pull-through suture strand until the first button exits the femoral hole, drilling a tibial hole and passing the needle with the pull-through suture strand through the tibial hole, applying a tensile force to the pull-through suture strand and the suture tape or strand of the construct such that the first button lies sideways for passage through the tibial hole, flipping the first button to engage the first button against the medial tibial cortex and subsequently cutting and removing the pull-through suture strand, pulling free ends of the suture tape or strand to advance a second button of the suture-button construct and to seat the second button against the femur, and securing the second button against the femur.

Abstract translation: 用于使用缝线按钮构造来稳定犬颅内十字韧带缺陷窒息的装置和方法。 该方法包括以下步骤：穿过股骨远端钻出股骨孔，使针穿过缝合线按钮构造的穿过缝合线通过股骨孔，并将拉力施加到穿过缝合线和 缝合带或线束，使得缝合线按钮构造的第一按钮侧向用于通过股骨孔，通过拉动穿通缝合线将第一按钮推进通过股孔，直到第一按钮离开股骨 穿过胫骨孔并穿过穿过缝合线的针穿过胫骨孔，向穿过缝合线和构造物的缝合带或股线施加张力，使得第一按钮位于侧面 通过胫骨孔，翻转第一按钮以将第一按钮接合到胫骨内侧皮质上，随后切割和移除穿过的缝合线，拉动fr 缝合带或股线的ee端部，以推进缝线按钮构造的第二按钮并将第二按钮抵靠股骨固定，并将第二按钮固定在股骨上。

公开(公告)号：US07875057B2

公开(公告)日：2011-01-25

申请号：US12010184

申请日：2008-01-22

Applicant: James L. Cook ,  David O. Shepard ,  Anthony Orozco

Inventor： James L. Cook ,  David O. Shepard ,  Anthony Orozco

IPC: A61B17/04 ,  A61B17/84 ,  A61F2/08

CPC classification number: A61D1/00 ,  A61B17/06066 ,  A61B17/1637 ,  A61B17/1675 ,  A61B2017/0404 ,  A61F2/0805 ,  A61F2/0811 ,  A61F2002/0882

Abstract: A method for stabilization of a cranial cruciate ligament in canines using a suture-button construct. The method includes the steps of drilling a hole across the femur and the tibia, passing a needle with a pull-through suture strand through the femoral hole, and applying a tensile force to the pull-through suture strand and a suture tape such that a first button lies sideways for passage through the femoral hole, advancing the first button through the femoral hole until the first button exits the femoral hole, passing the needle with the pull-through suture strand through the tibial hole, applying a tensile force to the pull-through suture strand and the suture tape such that the first button lies sideways for passage through the tibial hole, flipping the first button to engage it against the tibia, pulling free ends of the suture tape to advance a second button and to seat and secure it against the femur.

Abstract translation: 使用缝线按钮构造来稳定犬颈部十字韧带的方法。 该方法包括以下步骤：穿过股骨和胫骨穿孔，将穿过缝合线的针穿过股骨孔，以及向拉穿缝合线和缝线带施加张力，使得 第一按钮侧向通过股骨孔，使第一按钮通过股骨孔，直到第一按钮离开股骨孔，使针穿过缝合线通过胫骨孔，向拉力施加张力 通过缝合线和缝合带使得第一按钮位于侧面以通过胫骨孔，翻转第一按钮以将其接合到胫骨上，拉动缝线带的自由端以推进第二按钮并且座位和固定 它反对股骨。

公开(公告)号：US20080195148A1

公开(公告)日：2008-08-14

申请号：US12010184

申请日：2008-01-22

Applicant: James L. Cook ,  David O. Shepard ,  Anthony Orozco

Inventor： James L. Cook ,  David O. Shepard ,  Anthony Orozco

IPC: A61B17/04

CPC classification number: A61D1/00 ,  A61B17/06066 ,  A61B17/1637 ,  A61B17/1675 ,  A61B2017/0404 ,  A61F2/0805 ,  A61F2/0811 ,  A61F2002/0882

Abstract: An apparatus and method for stabilization of a cranial cruciate ligament deficient stifle in canines using a suture-button construct. The method includes the steps of drilling a femoral hole across a distal femur, passing a needle with a pull-through suture strand of a suture-button construct through the femoral hole, and applying a tensile force to the pull-through suture strand and a suture tape or strand of the construct such that a first button of the suture-button construct lies sideways for passage through the femoral hole, advancing the first button through the femoral hole by pulling the pull-through suture strand until the first button exits the femoral hole, drilling a tibial hole and passing the needle with the pull-through suture strand through the tibial hole, applying a tensile force to the pull-through suture strand and the suture tape or strand of the construct such that the first button lies sideways for passage through the tibial hole, flipping the first button to engage the first button against the medial tibial cortex and subsequently cutting and removing the pull-through suture strand, pulling free ends of the suture tape or strand to advance a second button of the suture-button construct and to seat the second button against the femur, and securing the second button against the femur.

Abstract translation: 用于使用缝线按钮构造来稳定犬颅内十字韧带缺陷窒息的装置和方法。 该方法包括以下步骤：穿过股骨远端钻出股骨孔，使针穿过缝合线按钮构造的穿过缝合线通过股骨孔，并将拉力施加到穿过缝合线和 缝合带或线束，使得缝合线按钮构造的第一按钮侧向用于通过股骨孔，通过拉动穿通缝合线将第一按钮推进通过股孔，直到第一按钮离开股骨 穿过胫骨孔并穿过穿过缝合线的针穿过胫骨孔，向穿过缝合线和构造物的缝合带或股线施加张力，使得第一按钮位于侧面 通过胫骨孔，翻转第一按钮以将第一按钮接合到胫骨内侧皮质上，随后切割和移除穿过的缝合线，拉动fr 缝合带或股线的ee端部，以推进缝线按钮构造的第二按钮并将第二按钮抵靠股骨固定，并将第二按钮固定在股骨上。