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    Transgenic flies expressing tau and amyloid precursor fragment
    1.
    发明申请
    Transgenic flies expressing tau and amyloid precursor fragment 审中-公开
    表达tau和淀粉样前体片段的转基因蝇

    公开(公告)号：US20080076145A1

    公开(公告)日：2008-03-27

    申请号：US11818413

    申请日：2007-06-14

    申请人： Christopher Cummings ,  Matthew Mahoney ,  Carol Singh

    发明人： Christopher Cummings ,  Matthew Mahoney ,  Carol Singh

    IPC分类号： A01K67/00 ,  C12N5/06 ,  C12Q1/20 ,  G01N33/00

    CPC分类号： A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C07K14/4711 ,  C12N15/8509 ,  C12N2830/002 ,  C12N2830/008

    摘要： The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-β precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau protein. The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

    摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的羧基末端片段和表达APP和tau蛋白片段的双转基因飞蝇的转基因飞行物。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

    Device and method for automated transfer of small organisms
    2.
    发明申请
    Device and method for automated transfer of small organisms 审中-公开
    用于自动转移小生物的装置和方法

    公开(公告)号：US20070281347A1

    公开(公告)日：2007-12-06

    申请号：US11510521

    申请日：2006-08-25

    申请人： Matthew Boeckeler ,  Bryan Chavez ,  Christopher Cummings ,  Carol Singh ,  Thomas Low ,  Max Crittenden

    发明人： Matthew Boeckeler ,  Bryan Chavez ,  Christopher Cummings ,  Carol Singh ,  Thomas Low ,  Max Crittenden

    IPC分类号： C12N1/00

    CPC分类号： G01N1/28 ,  B01L3/5635 ,  B01L2300/047 ,  G01N35/1074

    摘要： A device is disclosed for transferring an organism from a donor container to a recipient container. The device comprises a transfer plate assembly comprising a first subassembly and a second subassembly. The transfer plate assembly positions donor containers and recipient containers in an inverted relationship so that the organism pass from the donor container to the recipient container. In addition, a method is presented for transferring a small organism from a donor container to a recipient container. The method includes engaging a donor container to a transfer plate assembly. The method discloses engaging a recipient container to the transfer plate assembly wherein the recipient container is in an inverted orientation to the donor container and rotating the transfer plate assembly so that the recipient container is positioned below the donor container which allows the small organism to be transferred.

    摘要翻译： 公开了一种用于将生物从供体容器转移到接受容器的装置。 该装置包括一个转印板组件，该转印板组件包括第一子组件和第二子组件。 转移板组件以反向关系定位供体容器和接收容器，使得生物体从供体容器传递到接收容器。 此外，提出了一种将小生物从供体容器转移到接收容器的方法。 该方法包括将供体容器接合到转印板组件。 该方法公开地将接收容器接合到转移板组件，其中接收容器处于与供体容器相反的方向并且转动传递板组件，使得接收容器位于供体容器下方，允许小生物被转移 。