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公开(公告)号：US07352510B2
公开(公告)日：2008-04-01
申请号：US11441552
申请日：2006-05-26
CPC分类号： G02B27/0994 , F21K9/62
摘要： Two integrating light pipes are optically coupled to a focusing element to produce light with uniform irradiance and intensity profiles. The first ILP stage is used to receive spatially non-uniform light from a single or multi-color source and produce a uniform irradiance distribution while leaving the intensity distribution substantially unaltered. The focusing optical element swaps the irradiance and intensity distributions received from the output of the first ILP and feeds it to a second ILP stage which, in turn, completes the spatial homogenization of the light by transforming the non-uniform irradiance received from the focusing element into an output of uniform irradiance. As a result of this sequence of transformations, a homogeneous multi-color light output, both in intensity and irradiance, is produced.
摘要翻译： 两个集成光管被光学耦合到聚焦元件以产生具有均匀辐照度和强度分布的光。 第一个ILP级用于从单个或多个颜色的源接收空间不均匀的光，并产生均匀的辐照度分布，同时使强度分布基本上保持不变。 聚焦光学元件交换从第一ILP的输出接收的辐照度和强度分布，并将其馈送到第二ILP级，第二ILP级通过转换从聚焦元件接收的不均匀的辐照度来完成光的空间均匀化 成为均匀辐照度的输出。 作为这种变换顺序的结果，产生了强度和辐照度均匀的多色光输出。
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公开(公告)号：US20050132425A1
公开(公告)日：2005-06-16
申请号：US10970189
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033
CPC分类号： A01K67/0333 , A01K67/0339 , A01K2267/0312
摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
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公开(公告)号：US20050132423A1
公开(公告)日：2005-06-16
申请号：US10969895
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的佛兰芒突变体型的转基因飞行物，以及表达Tau蛋白和人类Abeta42前体蛋白（APP）的双转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
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公开(公告)号：US20050132421A1
公开(公告)日：2005-06-16
申请号：US10969893
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/00 , A01K67/033 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的北极突变体版本的转基因飞行物，以及表达Tau蛋白质和人Abeta42二极体的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
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5.发明申请Method of treating neurological disorders using clotrimazole and derivatives thereof 审中-公开使用克霉唑及其衍生物治疗神经障碍的方法公开(公告)号：US20070037800A1
公开(公告)日：2007-02-15
申请号：US11473479
申请日：2006-06-23
IPC分类号： A61K31/5375 , A61K31/4196 , A61K31/4192 , A61K31/415 , A61K31/41
CPC分类号： A61K31/415 , A61K31/41 , A61K31/4192 , A61K31/4196 , A61K31/5375
摘要： Methods and pharmaceutical compositions are disclosed for treating neurological disorders, such as Huntington's disease or Alzheimer's disease. The methods involve the administration of a triarylmethane compound, such as clotrimazole, or a salt thereof.
摘要翻译： 公开了用于治疗诸如亨廷顿病或阿尔茨海默氏病之类的神经障碍的方法和药物组合物。 所述方法包括施用三芳基甲烷化合物，例如克霉唑或其盐。
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公开(公告)号：US20080259460A1
公开(公告)日：2008-10-23
申请号：US12080108
申请日：2008-03-31
CPC分类号： G02B27/0994
摘要： A non-uniform light source is combined with a system including an integrating light pipe, a mask placed at the output of the light pipe, and a focusing element placed one focal length beyond the light pipe output at an angle appropriate for directing the light toward the illumination plane of the system. The purpose of the mask is to attenuate areas of the light pipe output that correspond to high irradiance regions at the illumination plane. Accordingly, this combination of optical components produces light with desired irradiance profile, including a substantially uniform irradiance profile, at the illumination plane.
摘要翻译： 不均匀光源与包括集成光管，放置在光管输出端的掩模和聚焦元件的系统组合在一起，该聚焦元件以适于将光导向 系统的照明平面。 掩模的目的是衰减对应于照明平面处的高辐照度区域的光管输出的区域。 因此，这种光学组件的组合在照明平面处产生具有期望的辐照度分布的光，包括基本均匀的辐照度分布。
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公开(公告)号：US20080076145A1
公开(公告)日：2008-03-27
申请号：US11818413
申请日：2007-06-14
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C07K14/4711 , C12N15/8509 , C12N2830/002 , C12N2830/008
摘要： The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-β precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau protein. The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的羧基末端片段和表达APP和tau蛋白片段的双转基因飞蝇的转基因飞行物。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
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公开(公告)号：US20050132424A1
公开(公告)日：2005-06-16
申请号：US10969898
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Dutch mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Dutch peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的荷兰突变型的转基因飞蝇，以及表达Tau蛋白和人Abeta42前体蛋白的双重转基因蝇， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
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公开(公告)号：US20050108779A1
公开(公告)日：2005-05-19
申请号：US10852974
申请日：2004-05-25
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033
CPC分类号： A01K67/0333 , A01K67/0339 , A01K2267/0312
摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的意大利突变体型的转基因飞行物，以及表达Tau蛋白质和人类Abeta42前体蛋白质的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
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公开(公告)号：US20070281347A1
公开(公告)日：2007-12-06
申请号：US11510521
申请日：2006-08-25
申请人： Matthew Boeckeler , Bryan Chavez , Christopher Cummings , Carol Singh , Thomas Low , Max Crittenden
发明人： Matthew Boeckeler , Bryan Chavez , Christopher Cummings , Carol Singh , Thomas Low , Max Crittenden
IPC分类号： C12N1/00
CPC分类号： G01N1/28 , B01L3/5635 , B01L2300/047 , G01N35/1074
摘要： A device is disclosed for transferring an organism from a donor container to a recipient container. The device comprises a transfer plate assembly comprising a first subassembly and a second subassembly. The transfer plate assembly positions donor containers and recipient containers in an inverted relationship so that the organism pass from the donor container to the recipient container. In addition, a method is presented for transferring a small organism from a donor container to a recipient container. The method includes engaging a donor container to a transfer plate assembly. The method discloses engaging a recipient container to the transfer plate assembly wherein the recipient container is in an inverted orientation to the donor container and rotating the transfer plate assembly so that the recipient container is positioned below the donor container which allows the small organism to be transferred.
摘要翻译： 公开了一种用于将生物从供体容器转移到接受容器的装置。 该装置包括一个转印板组件，该转印板组件包括第一子组件和第二子组件。 转移板组件以反向关系定位供体容器和接收容器，使得生物体从供体容器传递到接收容器。 此外，提出了一种将小生物从供体容器转移到接收容器的方法。 该方法包括将供体容器接合到转印板组件。 该方法公开地将接收容器接合到转移板组件，其中接收容器处于与供体容器相反的方向并且转动传递板组件，使得接收容器位于供体容器下方，允许小生物被转移 。
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