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公开(公告)号：US08008307B2
公开(公告)日：2011-08-30
申请号：US11890338
申请日：2007-08-06
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20120071482A1
公开(公告)日：2012-03-22
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/53 , A61K31/52 , A61K31/519 , A61K31/506 , A61K31/505 , A61K31/437 , A61K31/44 , C07D251/48 , C07D487/04 , A61P35/00 , C07D401/04 , C07D239/47 , C07D471/04 , C07D211/98 , C07D473/28 , C12N9/99
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US08481550B2
公开(公告)日：2013-07-09
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号：US07572784B2
公开(公告)日：2009-08-11
申请号：US11127855
申请日：2005-05-12
申请人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： A61P35/00 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20120178739A1
公开(公告)日：2012-07-12
申请号：US13419663
申请日：2012-03-14
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110039820A1
公开(公告)日：2011-02-17
申请号：US12903370
申请日：2010-10-13
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07459448B2
公开(公告)日：2008-12-02
申请号：US11242413
申请日：2005-10-03
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07935694B2
公开(公告)日：2011-05-03
申请号：US12231661
申请日：2008-09-04
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
IPC分类号： A61P35/00
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20090299060A1
公开(公告)日：2009-12-03
申请号：US12472583
申请日：2009-05-27
申请人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20090105213A1
公开(公告)日：2009-04-23
申请号：US12231661
申请日：2008-09-04
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
IPC分类号： A61K31/55 , A61K31/397 , A61P35/00
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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