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公开(公告)号：US08481550B2
公开(公告)日：2013-07-09
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号：US08008307B2
公开(公告)日：2011-08-30
申请号：US11890338
申请日：2007-08-06
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20120071482A1
公开(公告)日：2012-03-22
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/53 , A61K31/52 , A61K31/519 , A61K31/506 , A61K31/505 , A61K31/437 , A61K31/44 , C07D251/48 , C07D487/04 , A61P35/00 , C07D401/04 , C07D239/47 , C07D471/04 , C07D211/98 , C07D473/28 , C12N9/99
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20110136834A1
公开(公告)日：2011-06-09
申请号：US13025621
申请日：2011-02-11
IPC分类号： A61K31/519 , C12N9/99 , A61P25/28 , C07D498/04 , A61P35/00 , A61K31/52 , A61P31/00 , A61P29/00 , A61P37/00 , C07D473/00
CPC分类号： C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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![Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes](/abs-image/US/2011/05/31/US07951810B2/abs.jpg.150x150.jpg)
5.发明授权Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes 有权取代的吡咯并[2,3-d]嘧啶作为E1活化酶的抑制剂公开(公告)号：US07951810B2
公开(公告)日：2011-05-31
申请号：US11346469
申请日：2006-02-02
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P25/28 , A61P29/00
CPC分类号： C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要： This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5′, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及式（I-A）化合物，其中环A和变量X，Y，R 3a，R 3b，R 3c，R 3d，R 4，R 5，R 5'和m如本文所定义。 式（I-A）化合物抑制E1活化酶，包含该化合物的药物组合物和使用该化合物的方法。 本发明的化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20120258977A1
公开(公告)日：2012-10-11
申请号：US13527018
申请日：2012-06-19
IPC分类号： C07D487/04 , A61P25/28 , A61P29/00 , A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K31/52 , C07D403/04 , C07D405/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D519/00
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号：US20120258927A1
公开(公告)日：2012-10-11
申请号：US13526946
申请日：2012-06-19
IPC分类号： A61K31/519 , C07H19/16 , C07C35/06 , C07D493/04 , C07F7/18 , C07D303/14 , C07D487/04 , C07D473/34 , A61K31/7076 , A61K31/7064 , C12N9/99 , A61P35/00 , A61P37/00 , A61P9/00 , A61K31/52 , A61K31/5025 , C07H19/14
CPC分类号： A61K31/519 , A61K31/52 , C07D403/04 , C07D405/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D519/00
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20130165457A9
公开(公告)日：2013-06-27
申请号：US13527018
申请日：2012-06-19
IPC分类号： C07D487/04 , A61P25/28 , A61P29/00 , A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K31/52 , C07D403/04 , C07D405/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D519/00
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US08207177B2
公开(公告)日：2012-06-26
申请号：US11700614
申请日：2007-01-31
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P25/28 , A61P29/00
CPC分类号： A61K31/519 , A61K31/52 , C07D403/04 , C07D405/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D519/00
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US09139589B2
公开(公告)日：2015-09-22
申请号：US12657853
申请日：2010-01-28
IPC分类号： C07D345/00 , C07D517/00 , C07D487/04 , C07D417/04 , C07D419/14 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , C07D417/04 , C07D419/14 , C07D471/04 , C07D513/04
摘要： This invention provides compounds of formula IA or IB: wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
摘要翻译： 本发明提供式IA或IB的化合物：其中R1，R2，G1和HY如说明书中所述。 化合物是PI3K和/或mTor的抑制剂，因此可用于治疗增殖性，炎性或心血管疾病。
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