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公开(公告)号：US20120071482A1
公开(公告)日：2012-03-22
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/53 , A61K31/52 , A61K31/519 , A61K31/506 , A61K31/505 , A61K31/437 , A61K31/44 , C07D251/48 , C07D487/04 , A61P35/00 , C07D401/04 , C07D239/47 , C07D471/04 , C07D211/98 , C07D473/28 , C12N9/99
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20120064138A1
公开(公告)日：2012-03-15
申请号：US13265511
申请日：2009-04-28
申请人： David Beveridge , Stephen Critchley , Karen Nicola Harvey , Jeffrey Ronald King , Kenneth Miller McCombe , Martyn Howard Pendlebury
发明人： David Beveridge , Stephen Critchley , Karen Nicola Harvey , Jeffrey Ronald King , Kenneth Miller McCombe , Martyn Howard Pendlebury
CPC分类号： A01N59/16 , A01N59/20 , A61L15/46 , A61L27/34 , A61L27/50 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/624 , C09D5/14 , A01N25/10 , A01N25/34
摘要： The present invention relates to a biocidal composition comprising an inorganic compound and a polymer where the inorganic compound has been prepared using a controlled precipitation technique. The biocidal compositions overcome the settling and agglomeration problems of conventional inorganic biocidal compositions and offer enhanced activity, consistency, and stable long term release of the active species. The invention also relates to a method of preparation of the compositions and to their use as a biocidal composition and in making or coating articles comprising it.
摘要翻译： 本发明涉及包含无机化合物和聚合物的杀生物组合物，其中使用受控沉淀技术制备无机化合物。 杀生物组合物克服了常规无机杀生物组合物的沉降和聚集问题，并提供活性物质的活性，稠度和稳定的长期释放。 本发明还涉及组合物的制备方法及其作为杀生物剂组合物的用途，以及制备或包衣它们的制品。
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![Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes](/abs-image/US/2011/05/31/US07951810B2/abs.jpg.150x150.jpg)
3.发明授权Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes 有权取代的吡咯并[2,3-d]嘧啶作为E1活化酶的抑制剂公开(公告)号：US07951810B2
公开(公告)日：2011-05-31
申请号：US11346469
申请日：2006-02-02
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P25/28 , A61P29/00
CPC分类号： C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要： This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5′, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及式（I-A）化合物，其中环A和变量X，Y，R 3a，R 3b，R 3c，R 3d，R 4，R 5，R 5'和m如本文所定义。 式（I-A）化合物抑制E1活化酶，包含该化合物的药物组合物和使用该化合物的方法。 本发明的化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US08008307B2
公开(公告)日：2011-08-30
申请号：US11890338
申请日：2007-08-06
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20110136834A1
公开(公告)日：2011-06-09
申请号：US13025621
申请日：2011-02-11
IPC分类号： A61K31/519 , C12N9/99 , A61P25/28 , C07D498/04 , A61P35/00 , A61K31/52 , A61P31/00 , A61P29/00 , A61P37/00 , C07D473/00
CPC分类号： C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US08481550B2
公开(公告)日：2013-07-09
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号：US20060189636A1
公开(公告)日：2006-08-24
申请号：US11346469
申请日：2006-02-02
IPC分类号： A61K31/522 , A61K31/52 , A61K31/519 , C07D473/02 , C07D473/12
CPC分类号： C07H19/16 , C07D405/04 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07H19/048 , C07H19/14 , C07H19/23
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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公开(公告)号：US20080051404A1
公开(公告)日：2008-02-28
申请号：US11890338
申请日：2007-08-06
申请人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
发明人： Christopher Claiborne , Stephen Critchley , Courtney Cullis , Steven Langston , Hiro Mizutani , Edward Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel Weatherhead
IPC分类号： C07D473/32 , A61K31/44 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/53 , C12N9/99 , A61P35/00 , A61P37/00 , C07D211/92 , C07D239/24 , C07D251/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
摘要翻译： 本发明涉及抑制E1活化酶的化合物，包含该化合物的药物组合物和使用该化合物的方法。 该化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。
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