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1.发明申请COMPOUNDS HAVING BOTH ANGIOTENSIN II RECEPTOR ANTAGONISM AND PPARy ACTIVATING ACTIVITIES 审中-公开具有两种血管紧张素II受体拮抗剂和PPAR活性活性的化合物公开(公告)号：US20100029710A1
公开(公告)日：2010-02-04
申请号：US12518472
申请日：2007-12-03
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
IPC分类号： A61K31/437 , C07D471/04 , A61P3/10 , A61P3/00 , A61P9/12
CPC分类号： C07D471/04
摘要： Compounds of following formula (I) are provided that have both angiotensin II receptor antagonist activity and PPARy agonist activity. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment of diseases with the compounds including type 2 diabetes, insulin resistance, hyperinsulinemia, hyperlipidemia, hypertriglyceridemia, metabolic syndrome, congestive heart failure, and hypertension.
摘要翻译： 提供了具有血管紧张素II受体拮抗剂活性和PPARγ激动剂活性的下式（I）的化合物。 还提供了包含该化合物的药物组合物和用包括2型糖尿病，胰岛素抵抗，高胰岛素血症，高脂血症，高甘油三酯血症，代谢综合征，充血性心力衰竭和高血压的化合物治疗疾病的方法。
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2.发明申请Inhibitors of Factor XA and Other Serine Proteases Involved in the Coagulation Cascade 审中-公开因子XA和涉及凝血级联的其他丝氨酸蛋白酶的抑制剂公开(公告)号：US20080287674A1
公开(公告)日：2008-11-20
申请号：US12147038
申请日：2008-06-26
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
IPC分类号： C07D403/12 , C07D207/16 , C07D401/12 , C07D401/14
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： Compounds useful as intermediates for synthesis of compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification.
摘要翻译： 可用作合成式（I）化合物的中间体的化合物：其中A，B，C，G和W 1具有说明书中定义的任何值。
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3.发明申请INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE 审中-公开因子XA和其他凝血酶参与的其他丝氨酸蛋白酶的抑制剂公开(公告)号：US20090221546A1
公开(公告)日：2009-09-03
申请号：US12139799
申请日：2008-06-16
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
IPC分类号： A61K31/4025 , C07D207/16 , A61K31/40 , A61P7/02 , C07D205/08
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： Compounds useful as intermediates for synthesis of compounds of Formula (1): wherein A, B, C, G, and W1 have any of the values defined in the specification.
摘要翻译： 可用作合成式（1）化合物的中间体的化合物：其中A，B，C，G和W1具有说明书中定义的任何值。
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4.发明授权Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade 失效因子Xa和参与凝血级联的其他丝氨酸蛋白酶的抑制剂公开(公告)号：US07030141B2
公开(公告)日：2006-04-18
申请号：US10278643
申请日：2002-10-23
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
IPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , A61K31/40 , A61K31/4412
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
摘要翻译： 本发明提供式（I）的化合物：其中A，B，C，G和W 1具有说明书中定义的任何值及其药学上可接受的盐，其可用于 治疗血栓形成障碍。 还公开了包含一种或多种式I化合物，制备式I化合物的方法和可用于制备式I化合物的中间体的药物组合物。
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公开(公告)号：US07407974B2
公开(公告)日：2008-08-05
申请号：US11108582
申请日：2005-04-18
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Danette Andrea Dudley , Jeremy John Edmunds , Kevin James Filipski , Jeffrey Thomas Kohrt , Chad Alan Van Huis
IPC分类号： A61K31/4412 , A61K31/4015 , A61P9/10 , C07D207/09 , C07D207/50 , C07D403/10 , C07D207/10 , C07D295/10 , C07D231/04 , C07D403/14 , C07D249/08 , C07D487/04 , C07D257/04 , C07D257/10 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D409/10
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
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6.发明申请公开(公告)号：US20120022058A1
公开(公告)日：2012-01-26
申请号：US13262854
申请日：2010-03-26
申请人： Graciela Barbieri Arhancet , Agustin Casimiro-Garcia , Xiangyang Chen , David Hepworth , Marvin Jay Meyers , David Walter Piotrowski , Raj Kumar Raheja
发明人： Graciela Barbieri Arhancet , Agustin Casimiro-Garcia , Xiangyang Chen , David Hepworth , Marvin Jay Meyers , David Walter Piotrowski , Raj Kumar Raheja
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61K31/517 , C07D413/10 , A61K31/538 , A61K31/4709 , A61P9/00 , A61P13/12 , A61P1/16 , A61P29/00 , A61P25/00 , A61P5/48 , A61P3/10 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.
摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。
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公开(公告)号：US06569897B1
公开(公告)日：2003-05-27
申请号：US09581927
申请日：2000-06-19
IPC分类号： A61K31216
CPC分类号： C07C69/94 , C07C65/28 , C07C317/46 , C07C323/16 , C07C323/62 , C07D263/32
摘要： Alkenyldiarylmethane (ADAM) compounds have been found effective as anti-HIV agents. Novel ADAM compounds, their pharmaceutical formulations and a method of using same to treat viral infections are described.
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8.发明申请Inhibitors of fractor Xa and other serine proteases involved in the coagulation cascade 失效分裂Xa和其他丝氨酸蛋白酶的抑制剂参与凝血级联公开(公告)号：US20050250815A1
公开(公告)日：2005-11-10
申请号：US11108582
申请日：2005-04-18
申请人： Christopher Bigge , Agustin Casimiro-Garcia , Danette Dudley , Jeremy Edmunds , Kevin Filipski , Jeffrey Kohrt , Chad Van Huis
发明人： Christopher Bigge , Agustin Casimiro-Garcia , Danette Dudley , Jeremy Edmunds , Kevin Filipski , Jeffrey Kohrt , Chad Van Huis
IPC分类号： C07D231/06 , A61K20060101 , A61K31/40 , A61K31/4015 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P20060101 , A61P3/10 , A61P7/02 , A61P9/04 , A61P9/10 , A61P35/00 , C07D20060101 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D237/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D521/00
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
摘要翻译： 本发明提供式（I）的化合物：其中A，B，C，G和W 1具有说明书中定义的任何值及其药学上可接受的盐，其可用于 治疗血栓形成障碍。 还公开了包含一种或多种式I化合物，制备式I化合物的方法和可用于制备式I化合物的中间体的药物组合物。
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公开(公告)号：US20110281854A1
公开(公告)日：2011-11-17
申请号：US13104430
申请日：2011-05-10
IPC分类号： A61K31/5415 , A61K31/5383 , C07D413/04 , A61K31/5377 , A61P9/00 , A61P13/12 , A61P3/10 , A61P29/00 , A61P25/04 , C07D498/04 , A61P1/16
CPC分类号： C07D498/04 , C07D413/04 , C07D417/04 , C07D419/04
摘要： Mineralocorticoid receptor antagonists (MRa), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetic nephropathy and hypertension in mammals, including humans.
摘要翻译： 皮质激素受体拮抗剂（MRa），含有这些抑制剂的药物组合物，以及这些抑制剂在哺乳动物（包括人）中治疗例如糖尿病肾病和高血压的用途。
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10.发明申请INHIBITORS OF FACTOR Xa AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE 审中-公开因子Xa和其他凝血酶参与的其他丝氨酸蛋白酶的抑制剂公开(公告)号：US20060264626A1
公开(公告)日：2006-11-23
申请号：US11461859
申请日：2006-08-02
IPC分类号： C07D401/02 , C07D213/22 , C07D211/72 , C07D231/12
CPC分类号： C07D231/12 , C07D207/16 , C07D207/20 , C07D207/22 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/76 , C07D213/64 , C07D231/06 , C07D233/56 , C07D237/14 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： Compounds useful as intermediates for synthesis of compounds of Formula (1): wherein A, B, C, G, and W1 have any of the values defined in the specification.
摘要翻译： 可用作合成式（1）化合物的中间体的化合物：其中A，B，C，G和W 1具有说明书中定义的任何值。
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