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公开(公告)号：US06933369B2
公开(公告)日：2005-08-23
申请号：US10349806
申请日：2003-01-22
申请人： Christopher G. Mueller , Serge J. E. Lebecque , Yong-Jun Liu , Lynette M. Dowling , Constance F. Huffine , Daniel M. Gorman
发明人： Christopher G. Mueller , Serge J. E. Lebecque , Yong-Jun Liu , Lynette M. Dowling , Constance F. Huffine , Daniel M. Gorman
CPC分类号： C12N9/0022 , A61K38/00 , C07K2319/00 , C12N9/16 , C12N9/6489 , Y10S435/975
摘要： Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的各种蛋白酶，与其相关的试剂（包括特异性抗体）和纯化的蛋白质的核酸。 还提供使用所述试剂和相关诊断试剂盒的方法。
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公开(公告)号：US20100130724A1
公开(公告)日：2010-05-27
申请号：US12174889
申请日：2008-07-17
IPC分类号： C07K14/00
CPC分类号： C07K14/54
摘要： Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子的纯化基因，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US20050014199A1
公开(公告)日：2005-01-20
申请号：US10927228
申请日：2004-08-25
申请人： Pedro Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
发明人： Pedro Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Bazan , Robert Kastelein
IPC分类号： C07K14/54 , C07K14/715 , C12N15/12 , G01N33/53
CPC分类号： C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要： Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译： 编码哺乳动物细胞因子受体的核酸，例如用于细胞因子IL-B50，纯化的蛋白质和其片段。还提供了多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号：US06660523B2
公开(公告)日：2003-12-09
申请号：US09954905
申请日：2001-09-18
申请人： Bianca Blom , Yong-Jun Liu
发明人： Bianca Blom , Yong-Jun Liu
IPC分类号： C12N500
CPC分类号： C12N5/0639 , A61K2035/124 , A61K2039/5154 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2501/52 , C12N2502/99
摘要： Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
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公开(公告)号：US09422355B2
公开(公告)日：2016-08-23
申请号：US12174871
申请日：2008-07-17
CPC分类号： C07K14/54
摘要： Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子的纯化基因，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US09163085B2
公开(公告)日：2015-10-20
申请号：US14240535
申请日：2012-02-09
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
摘要翻译： 公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。 优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。 抗体可以是全长抗体或其抗原结合部分。 抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。 提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。
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公开(公告)号：US20120269825A1
公开(公告)日：2012-10-25
申请号：US13456589
申请日：2012-04-26
申请人： Yong-Jun Liu , Tomoki Ito
发明人： Yong-Jun Liu , Tomoki Ito
IPC分类号： A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： G01N33/5011 , A61K2039/505 , C07K16/2878 , C07K2317/73 , C07K2317/75 , G01N2333/5434 , G01N2333/70578
摘要： Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX40L. OX40L inhibits the generation of Tr1 cells from naïve and memory CD4+ T cells. This unique function of OX40L is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. It has been shown that signaling the OX40-receptor on human T cells by antibodies, small molecules, or the OX40L modulates the generation and function of IL-10 producing Foxp3+ Treg immunosuppressive T cells and blocks Foxp3+ Treg function. Further, provided are high throughput methods for identifying compounds that can inhibit the immunosuppressive function of IL-10 producing Tr1 cells.
摘要翻译： 可以通过靶向OX40 / OX40L来治疗许多疾病状态，例如人类过敏，自身免疫和自身免疫性疾病和癌症。 OX40L抑制从初始和记忆的CD4 + T细胞产生Tr1细胞。 OX40L的这种独特功能不是由另外两种共刺激的TNF-家族成员，GITR-配体和4-1BB-配体共享。 已经表明，通过抗体，小分子或OX40L来传递人T细胞上的OX40受体，调节IL-10产生的Foxp3 + Treg免疫抑制性T细胞的产生和功能并阻断Foxp3 + Treg功能。 此外，提供了用于鉴定可以抑制产生IL-10的Tr1细胞的免疫抑制功能的化合物的高通量方法。
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公开(公告)号：US07569224B2
公开(公告)日：2009-08-04
申请号：US11297957
申请日：2005-12-09
申请人： Pedro A. Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
发明人： Pedro A. Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要： Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号：US07271248B2
公开(公告)日：2007-09-18
申请号：US10975909
申请日：2004-10-28
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
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公开(公告)号：US09006399B2
公开(公告)日：2015-04-14
申请号：US13818645
申请日：2011-08-23
申请人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
发明人： Yong-Jun Liu , Kui Shin Voo , Laura Bover , Naoya Tsurushita , J. Yun Tso , Shankar Kumar
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75
摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
摘要翻译： 公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。 优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。 抗体可以是全长抗体或其抗原结合部分。 抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。 提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。
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