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1.发明授权公开(公告)号：US08021340B2
公开(公告)日：2011-09-20
申请号：US12321962
申请日：2009-01-26
申请人： Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Abram D. Janis , Kelly A. Chapman
发明人： Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Abram D. Janis , Kelly A. Chapman
IPC分类号： A61M5/32
CPC分类号： A61F2/0077 , A61M39/0247 , A61M2039/0261 , A61M2039/0273 , A61M2039/0294
摘要： A medical apparatus and method of use for implanting a percutaneous catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve having a tapered forward portion to facilitate its insertion through an undersized incision. The sleeve provides an interior elongate passageway which extends from a sleeve proximal end to a sleeve distal end. The sleeve is intended to be percutaneously implanted through an incision in the patient's skin so that the sleeve distal end resides subcutaneously. The sleeve outer peripheral surface carries a layer of porous material intended to be placed under the patient's outer skin layer in contact with the dermis to promote tissue ingrowth for anchoring the sleeve and forming an infection resistant barrier. The sleeve passageway is dimensioned to snugly accommodate the outer surface of catheter while permitting the catheter to slide relative to the sleeve. A sealing device is mounted around the catheter adjacent to the sleeve proximal end to prevent deleterious material from migrating into the patient's body along the catheter outer surface. A locking member secured to the sleeve can be pivoted to an unlocked portion for permitting axial and rotational movement of said catheter relative to said sleeve and or to a locked position for preventing such relative movement.
摘要翻译： 一种用于将经皮导管植入患者体内的医疗装置和方法，该导管可以容易地定位，重新定位和替换。 该装置包括具有锥形向前部分的细长套筒，以便于其插入通过较小的切口。 套筒提供从套筒近端延伸到套管远端的内部细长通道。 套筒旨在通过患者皮肤中的切口经皮植入，使得套管远端皮下注入。 套筒外周表面带有一层多孔材料，其旨在放置在与真皮接触的患者外表层下方，以促进组织向内生长以锚定套筒并形成感染抗性屏障。 套筒通道的尺寸被设计成紧密地容纳导管的外表面，同时允许导管相对于套筒滑动。 密封装置围绕导管邻近套管近端安装，以防止有害材料沿着导管外表面迁移到患者体内。 固定到套筒上的锁定构件可以枢转到解锁部分，以允许所述导管相对于所述套筒的轴向和旋转运动，或者可以锁定到锁定位置，以防止这种相对运动。
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2.发明申请公开(公告)号：US20090171295A1
公开(公告)日：2009-07-02
申请号：US12321962
申请日：2009-01-26
申请人： Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Abram D. Janis , Kelly A. Chapman
发明人： Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Abram D. Janis , Kelly A. Chapman
CPC分类号： A61F2/0077 , A61M39/0247 , A61M2039/0261 , A61M2039/0273 , A61M2039/0294
摘要： A medical apparatus and method of use for implanting a percutaneous catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve having a tapered forward portion to facilitate its insertion through an undersized incision. The sleeve provides an interior elongate passageway which extends from a sleeve proximal end to a sleeve distal end. The sleeve is intended to be percutaneously implanted through an incision in the patient's skin so that the sleeve distal end resides subcutaneously. The sleeve outer peripheral surface carries a layer of porous material intended to be placed under the patient's outer skin layer in contact with the dermis to promote tissue ingrowth for anchoring the sleeve and forming an infection resistant barrier. The sleeve passageway is dimensioned to snugly accommodate the outer surface of catheter while permitting the catheter to slide relative to the sleeve. A sealing device is mounted around the catheter adjacent to the sleeve proximal end to prevent deleterious material from migrating into the patient's body along the catheter outer surface. A locking member secured to the sleeve can be pivoted to an unlocked portion for permitting axial and rotational movement of said catheter relative to said sleeve and or to a locked position for preventing such relative movement.
摘要翻译： 一种用于将经皮导管植入患者体内的医疗装置和方法，该导管可以容易地定位，重新定位和替换。 该装置包括具有锥形向前部分的细长套筒，以便于其插入通过较小的切口。 套筒提供从套筒近端延伸到套管远端的内部细长通道。 套筒旨在通过患者皮肤中的切口经皮植入，使得套管远端皮下注入。 套筒外周表面带有一层多孔材料，其旨在放置在与真皮接触的患者外表层下方，以促进组织向内生长以锚定套筒并形成感染抗性屏障。 套筒通道的尺寸被设计成紧密地容纳导管的外表面，同时允许导管相对于套筒滑动。 密封装置围绕导管邻近套管近端安装，以防止有害材料沿着导管外表面迁移到患者体内。 固定到套筒上的锁定构件可以枢转到解锁部分，以允许所述导管相对于所述套筒的轴向和旋转运动，或者可以锁定到锁定位置，以防止这种相对运动。
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3.发明申请Medical apparatus and method for facilitating the management of long term tunneled conduits 审中-公开促进长期隧道管道管理的医疗仪器和方法公开(公告)号：US20090069786A1
公开(公告)日：2009-03-12
申请号：US12286821
申请日：2008-10-01
申请人： Thomas M. Vesely , Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
发明人： Thomas M. Vesely , Christopher H. Porter , Claude A. Vidal , Russell J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
IPC分类号： A61M5/32
CPC分类号： A61F2/0077 , A61M25/0662 , A61M39/0247 , A61M2039/0273 , A61M2039/0279 , A61M2039/0294
摘要： A method and apparatus for facilitating the management of indwelling conduits to avoid and/or treat infections associated with long term implantation. A sleeve carrying a layer of porous material on its outer surface is percutaneous implanted to place the layer of porous material just under the patient's outer skin in contact with the patient's dermis where it functions to promote soft tissue ingrowth. A catheter passes through the sleeve passageway and along an interior body path to an interior destination site, e.g., an opening into a vein, i.e., venotomy site. Within about 3-6 weeks after implantation, the patient's dermal tissue integrates sufficiently with the sleeve porous material to physically anchor the sleeve and create an infection resistant barrier. Further, a tunnel, characterized by an epithelialized capsule, typically forms around the catheter along the interior body path extending to the interior destination site. After sufficient integration of the patient's soft tissue into the porous layer, the sleeve passageway can be used to pass various procedural tools to the tunnel and interior destination site without disturbing the tissue integrating barrier.
摘要翻译： 一种便于管理留置管道以避免和/或治疗与长期植入有关的感染的方法和装置。 在其外表面上承载多孔材料层的套管是经皮植入的，以将多孔材料层恰好放置在病人的外皮下方，与病人的真皮接触，其中它促进软组织向内生长。 导管穿过套管通道并沿着内部身体路径到达内部目的地，例如，进入静脉的开口，即静脉切开部位。 在植入后约3-6周内，患者的皮肤组织与套管多孔材料充分结合以物理地锚定套筒并产生感染抗性屏障。 此外，特征在于上皮化胶囊的隧道通常沿着延伸到内部目的地位置的内部主体路径围绕导管形成。 在将患者的软组织充分融合到多孔层中之后，可以使用套管通道将各种程序工具传递到隧道和内部目的地，而不会干扰组织整合屏障。
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4.发明授权公开(公告)号：US07731697B2
公开(公告)日：2010-06-08
申请号：US11708445
申请日：2007-02-20
申请人： Christopher H. Porter , Claude A. Vidal , Russ J Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
发明人： Christopher H. Porter , Claude A. Vidal , Russ J Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
IPC分类号： A61M5/32
CPC分类号： A61M39/0247 , A61F2/0077
摘要： A medical apparatus and method of use for implanting a catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve comprising a wall surrounding an interior passageway extending from a sleeve proximal end to a sleeve distal end. The sleeve is intended to be percutaneously implanted through an incision in the patient's skin to place the sleeve distal end subcutaneously. The sleeve distal end outer surface carries porous material intended to contact the patient's dermis to promote tissue ingrowth. The sleeve passageway is dimensioned to snugly accommodate the outer surface of the catheter while permitting the catheter to slide relative to the sleeve. A split ring locking member is selectively operable in an unlocked state for permitting axial and rotational movement of said catheter relative to said sleeve and operable in a locked state for preventing such relative movement.
摘要翻译： 一种用于将导管植入患者体内的医疗装置和方法，该导管可以容易地定位，重新定位和替换。 该装置包括细长的套筒，其包括围绕从套筒近端延伸到套管远端的内部通道的壁。 套筒旨在通过患者皮肤中的切口经皮植入以将套管远端皮下放置。 套管远端外表面承载用于接触患者真皮的多孔材料以促进组织向内生长。 套筒通道的尺寸被设计成紧密地容纳导管的外表面，同时允许导管相对于套筒滑动。 解锁环锁定构件可选择性地在解锁状态下操作，以允许所述导管相对于所述套筒的轴向和旋转运动，并且可在锁定状态下操作以防止这种相对移动。
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5.发明授权公开(公告)号：US07794431B2
公开(公告)日：2010-09-14
申请号：US11650795
申请日：2007-01-06
申请人： Christopher H. Porter , Claude A. Vidal , Russ J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
发明人： Christopher H. Porter , Claude A. Vidal , Russ J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
IPC分类号： A61M5/00
CPC分类号： A61F2/0077 , A61L29/146 , A61M39/0247 , A61M2039/0261 , H04R2225/67
摘要： A medical apparatus and method of use for implanting a percutaneous catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve comprising a wall surrounding an interior elongate passageway. The passageway extends from a sleeve proximal end to a sleeve distal end. The sleeve is intended to be percutaneously implanted through an incision in the patient's skin so that the sleeve distal end resides subcutaneously. The sleeve outer peripheral surface carries a layer of porous material intended to be placed just under the patient's outer skin layer in contact with the dermis to promote tissue ingrowth for anchoring the sleeve and forming an infection resistant barrier. The sleeve passageway is dimensioned to snugly accommodate the outer surface of catheter while permitting the catheter to slide relative to the sleeve. A sealing device is mounted around the catheter adjacent to the sleeve proximal end to prevent deleterious material from migrating into the patient's body along the catheter outer surface.
摘要翻译： 一种用于将经皮导管植入患者体内的医疗装置和方法，该导管可以容易地定位，重新定位和替换。 该装置包括细长套筒，其包括围绕内部细长通道的壁。 通道从套筒近端延伸到套筒远端。 套筒旨在通过患者皮肤中的切口经皮植入，使得套管远端皮下注入。 套筒外周表面带有一层多孔材料，其旨在被放置在与真皮接触的患者外皮层正下方，以促进组织向内生长以锚定套筒并形成感染抗性屏障。 套筒通道的尺寸被设计成紧密地容纳导管的外表面，同时允许导管相对于套筒滑动。 密封装置围绕导管邻近套管近端安装，以防止有害材料沿着导管外表面迁移到患者体内。
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6.发明申请Method and Subcutaneous Apparatus for Facilitating the Replacement of an Implanted Catheter 审中-公开用于促进植入式导管更换的方法和皮下装置公开(公告)号：US20100234814A1
公开(公告)日：2010-09-16
申请号：US12223047
申请日：2007-01-29
申请人： Christopher H. Porter , Claude A. Vidal , Russ J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
发明人： Christopher H. Porter , Claude A. Vidal , Russ J. Redmond , Byron L. Moran , Paul Kaluzniak , Abram D. Janis
IPC分类号： A61L15/46
CPC分类号： A61M25/0111 , A61M1/3661 , A61M25/0194 , A61M25/0668 , A61M39/0247 , A61M2025/0293 , A61M2025/0681 , A61M2039/0261 , A61M2039/0273
摘要： A medical apparatus and method of use for implanting a catheter in a patient's body which catheter can be easily positioned, repositioned, and replaced. The apparatus includes an elongate sleeve intended to be subcutaneously implanted. The sleeve comprises a wall surrounding an interior elongate passageway which extends from a sleeve proximal end to a sleeve distal end. The sleeve outer peripheral surface carries a layer of porous material intended to be placed just under the patient's outer skin layer in contact with the dermis to promote tissue ingrowth for anchoring the sleeve and forming an infection resistant barrier. The sleeve passageway includes a sealing nib dimensioned to engage the outer surface of the catheter while permitting the catheter to slide relative to the sleeve. The sealing nib prevents deleterious material from migrating into the patient's body along the catheter outer surface.
摘要翻译： 一种用于将导管植入患者体内的医疗装置和方法，该导管可以容易地定位，重新定位和替换。 该装置包括旨在皮下植入的细长套筒。 套筒包括围绕从套筒近端延伸到套管远端的内部细长通道的壁。 套筒外周表面带有一层多孔材料，其旨在被放置在与真皮接触的患者外皮层正下方，以促进组织向内生长以锚定套筒并形成感染抗性屏障。 套筒通道包括密封笔尖，其尺寸适于与导管的外表面接合，同时允许导管相对于套筒滑动。 密封笔尖防止有害材料沿着导管外表面迁移到患者体内。
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7.发明申请公开(公告)号：US20090105545A1
公开(公告)日：2009-04-23
申请号：US12287130
申请日：2008-10-06
CPC分类号： A61B17/32093
摘要： An apparatus and method for facilitating the implantation of a medical device through an incision so as to promote soft tissue ingrowth into a biocompatible porous layer, e. g, titanium, carried on the periphery of the medical device. The method utilizes an incision (either percutaneous or subcutaneous) which is intentionally undersized by 10-20% relative to the width dimension of the porous layer. Accordingly, a physician must stretch the surrounding tissue to maximize the size of the opening to insert the device. Because the opening is undersized relative to the porous layer, the surrounding tissue remains physically stressed, i.e., radially and/or circumferentially, and acts to enhance cell proliferation and healing. A surgical cutting tool is preferably provided to assist the physician to form a properly dimensioned opening.
摘要翻译： 一种便于通过切口植入医疗装置的装置和方法，以便促进软组织向生长相容性多孔层的向内生长，例如， g，钛，携带在医疗装置的周边。 该方法使用有意地相对于多孔层的宽度尺寸小于10-20％的切口（经皮或皮下）。 因此，医生必须拉伸周围的组织以最大化开口的尺寸以插入装置。 由于开口相对于多孔层尺寸过小，周围的组织保持物理应力，即径向和/或周向，并且用于增强细胞增殖和愈合。 优选地提供外科切割工具以帮助医师形成适当尺寸的开口。
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8.发明授权公开(公告)号：US08641778B2
公开(公告)日：2014-02-04
申请号：US12735452
申请日：2009-01-21
申请人： Alfred E. Mann , Byron L. Moran , Abram D. Janis , Paul Kaluzniak
发明人： Alfred E. Mann , Byron L. Moran , Abram D. Janis , Paul Kaluzniak
IPC分类号： A61F2/78
CPC分类号： A61B17/8625 , A61B17/60 , A61F2/2814 , A61F2/30749 , A61F2/78 , A61F2002/0086 , A61F2002/30013 , A61F2002/30029 , A61F2002/30434 , A61F2002/30448 , A61F2002/30451 , A61F2002/3093 , A61F2002/7887 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2250/0024 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00149
摘要： A method and apparatus for reducing the incident of infection proximate to an exit site where a prosthesis fastener, e.g., a bone screw, percutaneously penetrates a patient's skin/soft tissue. Infection reduction is achieved in accordance with the invention by growing a tissue integrating seal around the fastener proximate to the exit site.
摘要翻译： 用于减少接近出口部位的感染事件的方法和装置，其中假体紧固件（例如骨螺钉）经皮穿透患者的皮肤/软组织。 根据本发明通过在邻近出口部位附近围绕紧固件生长组织集成密封来实现感染减少。
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公开(公告)号：US20120203199A1
公开(公告)日：2012-08-09
申请号：US13373787
申请日：2011-11-30
CPC分类号： A61M25/04 , A61M25/0017 , A61M25/0068 , A61M25/0606 , A61M25/0643 , A61M29/00 , A61M39/0208 , A61M39/0247 , A61M2039/0223 , A61M2039/0261
摘要： Catheter systems and methods for facilitating the delivery of a therapeutic agent directly to the interior of a body organ, and/or the extraction of material from said organ. The catheter distal end is placed within the body organ to be treated. The catheter may carry a fixation device near the catheter distal end. When implanted, the fixation device retains the catheter distal end in the organ despite normal patient activity. The fixation device may include porous material to promote soft tissue ingrowth for anchoring the catheter distal end within the organ.
摘要翻译： 用于促进将治疗剂直接递送到身体器官内部的导管系统和方法，和/或从所述器官提取材料。 将导管远端放置在待治疗的身体器官内。 导管可以在导管远端附近携带固定装置。 当植入时，尽管正常的患者活动，但是固定装置将导管远端保持在器官中。 固定装置可以包括多孔材料以促进软组织向内生长以将导管远端锚定在器官内。
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10.发明授权Growth factor modified extracellular matrix material preparation and methods for preparation and use thereof 有权生长因子修饰细胞外基质材料的制备及其制备及使用方法公开(公告)号：US08591930B2
公开(公告)日：2013-11-26
申请号：US12110630
申请日：2008-04-28
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61L27/20 , A61L27/3604 , A61L27/50 , C08L5/10
摘要： Described are tissue graft constructs that include submucosa and other extracellular matrix materials that incorporate a number of exogenous proteins. Further described are methods for making tissue graft constructs that include stripping endogenous heparin binding proteins from a porcine graft material and thereafter binding one or more human growth factors to the native heparin molecules that are retained within the graft material. Such graft materials may be used in methods for the treatment of wounds in patients.
摘要翻译： 描述的是包括粘膜下层和其它外源蛋白质的细胞外基质材料的组织移植物构建体。 还描述了用于制备组织移植构建体的方法，其包括从猪移植材料中剥离内源性肝素结合蛋白，然后将一种或多种人生长因子结合到保留在移植材料内的天然肝素分子。 这样的移植材料可以用于治疗患者的伤口的方法中。
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